Development Level

Tbio 6 | 11,445
Tchem 2 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal testis morphology 1 | 43
decreased eosinophil cell numb... 1 | 24
edema 1 | 59
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148

Disease

Cancer 6 | 2,499
lung carcinoma 6 | 2,843
Liver Cirrhosis, Experimental 5 | 769
cystic fibrosis 5 | 1,696
glioblastoma 5 | 5,792
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
Carcinoma 4 | 11,493
Pulmonary Fibrosis 4 | 106
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
tuberculosis 4 | 2,010
Aortic Valve Insufficiency 3 | 40
Breast cancer 3 | 3,578
Cleft Palate 3 | 271
Coronary artery disease 3 | 268
Craniosynostosis 3 | 74
Exophthalmos 3 | 112
Hypertension 3 | 396
Hypertensive disease 3 | 292
Kidney disease 3 | 430
Loeys-Dietz syndrome 3 | 23
Osteoarthritis 3 | 184
Prominent eyes 3 | 96
Prominent globes 3 | 96
Protruding eyes 3 | 96
Ureteral obstruction 3 | 33
adult high grade glioma 3 | 3,801
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 4,104
medulloblastoma, large-cell 3 | 6,241
pancreatic cancer 3 | 2,398
psoriasis 3 | 6,694
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Acquired flat foot 2 | 72
Acquired scoliosis 2 | 281
Aortic aneurysm, familial thoracic 3 2 | 13
Arachnodactyly 2 | 49
Ascending aortic dissection 2 | 13
Astrocytoma, Pilocytic 2 | 3,081
Bipolar Disorder 2 | 666
Blue sclera 2 | 32
Byzanthine arch palate 2 | 194
COPD 2 | 118
Cardiomegaly 2 | 116
Chest Pain 2 | 38
Cleft uvula 2 | 27
Colorectal Neoplasms 2 | 243
Craniofacial Abnormalities 2 | 151
Curvature of spine 2 | 282
Cutis marmorata 2 | 32
Cystic medial necrosis of aorta 2 | 13
Dental caries 2 | 164
Depressive disorder 2 | 409
Descending aortic dissection 2 | 13
Diabetic Nephropathies 2 | 37
Diabetic Nephropathy 2 | 34
Dyspnea on exertion 2 | 24
Dyspnea, Paroxysmal 2 | 13
Epilepsy 2 | 792
Exotropia 2 | 35
Flatfoot 2 | 73
Heart disease 2 | 306
Hepatitis, Chronic 2 | 23
Hernia, Inguinal 2 | 89
Impaired left ventricular function 2 | 16
Inflammatory bowel disease 2 | 151
Intermittent migraine headaches 2 | 68
Left-Sided Heart Failure 2 | 16
Liver Cirrhosis 2 | 181
Liver disease 2 | 237
Loeys-Dietz Aortic Aneurysm Syndrome 2 | 13
Lung Neoplasms 2 | 232
Malabsorption 2 | 82
Migraine Disorders 2 | 76
Multiple myeloma 2 | 1,332
Neoplasm Metastasis 2 | 168
Peyronie's disease 2 | 9
Pneumonia 2 | 174
Prostatic Neoplasms 2 | 495
Proteinuria 2 | 144
Retrognathia 2 | 54
Schizophrenia 2 | 1,160
Seizures 2 | 596
Squamous cell carcinoma 2 | 129
Tall stature 2 | 34
Waldenstrons macroglobulinemia 2 | 765
astrocytic glioma 2 | 2,597
dermatomyositis 2 | 966
gastric carcinoma 2 | 807
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung cancer 2 | 4,740
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
sarcoidosis 2 | 370

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Non-IDG 4 | 12,091
Transcription Factor 3 | 1,400
Enzyme 1 | 4,145
Kinase 1 | 634

GO Function

type I transforming growth fac... 9 | 9
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Sorting nexin-25 SNX25 Tbio Non-IDG -0.47192 3.47 114
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548
Mothers against decapentaplegic homolog 7 SMAD7 Tbio Transcription Factor -2.81953 638.7 387
Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Tclin Enzyme -2.77923 382.8 271
Mothers against decapentaplegic homolog 2 SMAD2 Tbio Transcription Factor -3.26675 1515.7 1396