Development Level

Tbio 4 | 11,445

IMPC Phenotype

increased total body fat amoun... 2 | 134
decreased bone mineral content 1 | 151
decreased lean body mass 1 | 135
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased leukocyte cell numbe... 1 | 47
increased red blood cell distr... 1 | 34
preweaning lethality, incomple... 1 | 499

Disease

Obesity 3 | 678
Arthritis 2 | 290
Hypersensitivity reaction type II disease 2 | 253
Inflammatory bowel disease 2 | 151
Melanoma 2 | 711
Rheumatic fever 2 | 19
Synovitis 2 | 78
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
osteosarcoma 2 | 7,950
pituitary cancer 2 | 1,972
psoriasis 2 | 6,694
tuberculosis 2 | 2,010
ACTH Syndrome, Ectopic 1 | 1
Acute Kidney Tubular Necrosis 1 | 6
Addison's disease 1 | 31
Adrenal Cortex Diseases 1 | 1
Adrenal gland hypofunction 1 | 9
Adrenocorticotropic hormone (ACTH) deficiency (disorder) 1 | 4
Alcohol abuse 1 | 50
Amnesia 1 | 17
Anxiety disorder 1 | 23
Aortic Stenosis, Subvalvular 1 | 1
Arthritis, Gouty 1 | 9
Arthropathy 1 | 43
Balanitis 1 | 4
Body Weight 1 | 14
Bronchus adenoma 1 | 1
Burns 1 | 9
Carney complex 1 | 25
Cervicitis 1 | 6
Chlamydia 1 | 21
Chondrocalcinosis 1 | 9
Chorioretinitis 1 | 6
Chronic fatigue syndrome 1 | 25
Congenital adrenal insufficiency 1 | 7
Craniopharyngioma 1 | 16
Cushing Syndrome 1 | 3
Cystitis 1 | 15
Diabetes insipidus 1 | 18
Drug dependence 1 | 3
Empty sella syndrome 1 | 6
Endophthalmitis 1 | 12
Enthesopathy 1 | 4
Epilepsy, Tonic-Clonic 1 | 10
Eye Diseases 1 | 2
Eye pain 1 | 2
Facial paralysis 1 | 18
Fat tissue increased 1 | 3
Femur Head Necrosis 1 | 3
Frozen shoulder 1 | 5
Hemorrhage 1 | 19
Hypernatremia 1 | 5
Hyperostosis 1 | 18
Hyperphagia 1 | 23
Hyperprolactinemia 1 | 27
Hypoglycaemic seizure 1 | 10
Hypothalamic disease 1 | 3
Immune System Diseases 1 | 4
Inappropriate ADH syndrome 1 | 5
Increased appetite (finding) 1 | 23
Infection 1 | 6
Iritis 1 | 8
Kidney Tubular Necrosis, Acute 1 | 4
Leydig cell tumor 1 | 9
Mental disorders 1 | 12
Motion sickness 1 | 21
Nelson syndrome 1 | 6
Neurogenic Inflammation 1 | 12
Neurohypophyseal diabetes insipidus 1 | 13
Ochronosis 1 | 4
Oliguria 1 | 8
Opsoclonus-Myoclonus Syndrome 1 | 1
Pancreatic Diseases 1 | 8
Penile Diseases 1 | 3
Pituitary ACTH Hypersecretion 1 | 3
Pituitary apoplexy 1 | 3
Postoperative Complications 1 | 4
Proopiomelanocortin Deficiency 1 | 1
Psoriatic arthritis 1 | 86
Red hair 1 | 6
Retinitis 1 | 7
Rhabdomyoma 1 | 1
SAPHO syndrome 1 | 10
Sacroiliitis 1 | 1
Secondary Adrenal Insufficiency 1 | 6
Septooptic dysplasia 1 | 19
Sleep Wake Disorders 1 | 7
Spasms, Infantile 1 | 6
Substance abuse 1 | 59
Tendinitis 1 | 14
Thyroiditis 1 | 29
Truncal obesity apparent in childhood 1 | 3
Tuberous sclerosis 1 | 19
Urinary Tract Infections 1 | 2
Urinary tract infection 1 | 2
Withdrawal disorder 1 | 19
X-linked adrenal hypoplasia congenita 1 | 11
pituitary-dependent Cushing's disease 1 | 5
pustulosis of palm and sole 1 | 5

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678
Male tissues 3 | 17,142
Nervous System 3 | 16,725

Target Family

Non-IDG 4 | 12,091

GO Function

type 4 melanocortin receptor b... 4 | 4
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-opiomelanocortin POMC Tbio Non-IDG -4.56004 36591.2 1334
Melanocortin-2 receptor accessory protein MRAP Tbio Non-IDG -3.60469 4145.9 102
Agouti-signaling protein ASIP Tbio Non-IDG -1.78281 57.2 34
Melanocortin-2 receptor accessory protein 2 MRAP2 Tbio Non-IDG -1.14701 15.0 86