Development Level

Tdark 95 | 6,588
Tbio 80 | 11,445
Tclin 16 | 613
Tchem 11 | 1,598

Collection

GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

abnormal gait 5 | 69
increased total body fat amoun... 4 | 134
preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased vertical activity 3 | 208
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
limb grasping 3 | 41
preweaning lethality, incomple... 3 | 499
small superior vagus ganglion 3 | 74
tremors 3 | 39
abnormal QT variability 2 | 10
abnormal bone structure 2 | 187
abnormal locomotor behavior 2 | 24
abnormal seminal vesicle morph... 2 | 114
abnormal snout morphology 2 | 23
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased heart weight 2 | 27
decreased leukocyte cell numbe... 2 | 73
enlarged heart 2 | 210
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
prolonged QRS complex duration 2 | 8
prolonged QT interval 2 | 38
thrombocytopenia 2 | 56
abnormal cecum morphology 1 | 7
abnormal digit morphology 1 | 10
abnormal eye anterior chamber ... 1 | 9
abnormal head morphology 1 | 10
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
aorta dilation 1 | 3
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased prepulse inhibition 1 | 82
decreased pulmonary respirator... 1 | 5
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged liver 1 | 2
enlarged stomach 1 | 2
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
small thymus 1 | 16
trunk curl 1 | 16

Disease

Carcinoma 134 | 11,493
osteosarcoma 70 | 7,950
psoriasis 57 | 6,694
lung cancer 52 | 4,740
Cancer 50 | 2,499
lung carcinoma 47 | 2,843
ovarian cancer 43 | 8,520
glioblastoma 38 | 5,792
interstitial cystitis 38 | 2,312
cutaneous lupus erythematosus 33 | 1,057
lung adenocarcinoma 33 | 2,716
invasive ductal carcinoma 32 | 2,951
diabetes mellitus 31 | 1,728
non-small cell lung cancer 31 | 2,890
Breast cancer 29 | 3,578
medulloblastoma, large-cell 29 | 6,241
Kidney cancer 28 | 2,613
adult high grade glioma 28 | 3,801
atypical teratoid / rhabdoid tumor 28 | 5,112
pancreatic cancer 27 | 2,398
tuberculosis 27 | 2,010
Astrocytoma, Pilocytic 26 | 3,081
ulcerative colitis 26 | 1,819
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
malignant mesothelioma 24 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
ependymoma 21 | 4,679
group 3 medulloblastoma 21 | 4,104
pituitary cancer 20 | 1,972
subependymal giant cell astrocytoma 20 | 2,287
Rheumatoid arthritis 19 | 1,191
Autosomal recessive predisposition 18 | 1,442
breast carcinoma 17 | 1,638
ductal carcinoma in situ 17 | 1,745
Schizophrenia 16 | 1,160
cystic fibrosis 15 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
primary Sjogren syndrome 15 | 735
Asthma 13 | 385
adrenocortical carcinoma 13 | 1,428
colon cancer 13 | 1,478
Arthritis 12 | 290
Obesity 12 | 678
group 4 medulloblastoma 12 | 1,855
nasopharyngeal carcinoma 12 | 1,058
primitive neuroectodermal tumor 12 | 3,035
Human immunodeficiency virus infectious disease 11 | 138
Skin cancer 11 | 469
oligodendroglioma 11 | 2,850
Hypersensitivity reaction type II disease 10 | 253
Inflammatory bowel disease 10 | 151
Melanoma 10 | 711
Multiple Sclerosis 10 | 540
Prostatic Neoplasms 10 | 495
gastric carcinoma 10 | 807
Allergic hypersensitivity disease 9 | 126
Atherosclerosis 9 | 291
Hypertension 9 | 396
Immunologic Deficiency Syndromes 9 | 113
Kidney disease 9 | 430
Liver cancer 9 | 604
Pick disease 9 | 1,894
Systemic lupus erythematosus 9 | 194
Thrombocytopenia 9 | 197
fibroadenoma 9 | 559
Atopic dermatitis 8 | 952
Dermatitis 8 | 157
Diarrhea 8 | 253
Influenza 8 | 142
Lymphoproliferative syndrome 8 | 58
aldosterone-producing adenoma 8 | 665
astrocytic glioma 8 | 2,597
pancreatic carcinoma 8 | 562
Alzheimer's disease 7 | 658
Breast Neoplasms 7 | 445
Chronic Lymphocytic Leukemia 7 | 262
Duchenne muscular dystrophy 7 | 601
Heart disease 7 | 306
Liver disease 7 | 237
Mammary Neoplasms 7 | 425
Pneumonia 7 | 174
non-small cell lung carcinoma 7 | 317
pediatric high grade glioma 7 | 1,064
sarcoidosis 7 | 370
Cerebrovascular disease 6 | 238
Coronary artery disease 6 | 268
Down syndrome 6 | 499
Endometriosis 6 | 540
Failure to gain weight 6 | 365
Hepatomegaly 6 | 285
Lung disease 6 | 142
Pediatric failure to thrive 6 | 365
Vascular disease 6 | 319
active Crohn's disease 6 | 922
astrocytoma 6 | 1,146
head and neck cancer 6 | 271
juvenile dermatomyositis 6 | 1,187
mucosa-associated lymphoid tissue lymphoma 6 | 484
periodontitis 6 | 293

Tissue

Endocrine System 124 | 18,159
Blood and immune system 110 | 16,909
Female tissues 109 | 17,400
Digestive Tract 106 | 17,369
Male tissues 104 | 17,142
Respiratory system 103 | 16,393
Skin and soft tissues 103 | 17,230
Urinary Tract 103 | 16,678
Liver and Pancreas 102 | 16,750
Nervous System 101 | 16,725
Cardiovascular System 96 | 15,192

Target Family

Non-IDG 93 | 12,091
oGPCR 89 | 421
GPCR 9 | 408
Ion Channel 4 | 344
Kinase 4 | 634
Enzyme 2 | 4,145
Transporter 1 | 473

GO Function

transmembrane signaling recept... 202 | 202
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Olfactory receptor 2A7 OR2A7 Tdark oGPCR 0.00000 23
Olfactory receptor 52A1 OR52A1 Tdark oGPCR 0.18 1.00 92
Olfactory receptor 4F4 OR4F4 Tdark oGPCR 0.00000 45
Olfactory receptor 4C12 OR4C12 Tdark oGPCR 0.31 0.30 74
Olfactory receptor 4K3 OR4K3 Tdark oGPCR 0.00000 0
Natural cytotoxicity triggering receptor 2 NCR2 Tbio Non-IDG -2.05295 100.7 196
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
Olfactory receptor 10J1 OR10J1 Tdark oGPCR 0.00000 40
Olfactory receptor 1E1 OR1E1 Tdark oGPCR -0.03218 1.09 6