Development Level

Tdark 95 | 6,593
Tbio 82 | 11,651
Tclin 16 | 612
Tchem 9 | 1,388

Collection

GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

abnormal gait 5 | 69
increased total body fat amoun... 4 | 134
preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased vertical activity 3 | 208
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
limb grasping 3 | 41
preweaning lethality, incomple... 3 | 499
small superior vagus ganglion 3 | 74
tremors 3 | 39
abnormal QT variability 2 | 10
abnormal bone structure 2 | 187
abnormal locomotor behavior 2 | 24
abnormal seminal vesicle morph... 2 | 114
abnormal snout morphology 2 | 23
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased heart weight 2 | 27
decreased leukocyte cell numbe... 2 | 73
enlarged heart 2 | 210
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
prolonged QRS complex duration 2 | 8
prolonged QT interval 2 | 38
thrombocytopenia 2 | 56
abnormal cecum morphology 1 | 7
abnormal digit morphology 1 | 10
abnormal eye anterior chamber ... 1 | 9
abnormal head morphology 1 | 10
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
aorta dilation 1 | 3
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased prepulse inhibition 1 | 82
decreased pulmonary respirator... 1 | 5
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged liver 1 | 2
enlarged stomach 1 | 2
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
small thymus 1 | 16
trunk curl 1 | 16

Disease

Carcinoma 134 | 11,493
osteosarcoma 70 | 7,950
psoriasis 57 | 6,694
lung cancer 52 | 4,740
Cancer 50 | 2,499
lung carcinoma 47 | 2,843
ovarian cancer 43 | 8,520
glioblastoma 38 | 5,792
interstitial cystitis 38 | 2,312
cutaneous lupus erythematosus 33 | 1,057
lung adenocarcinoma 33 | 2,716
invasive ductal carcinoma 32 | 2,951
diabetes mellitus 31 | 1,728
non-small cell lung cancer 31 | 2,890
Breast cancer 29 | 3,578
medulloblastoma, large-cell 29 | 6,241
Kidney cancer 28 | 2,613
adult high grade glioma 28 | 3,801
atypical teratoid / rhabdoid tumor 28 | 5,112
pancreatic cancer 27 | 2,398
tuberculosis 27 | 2,010
Astrocytoma, Pilocytic 26 | 3,081
ulcerative colitis 26 | 1,819
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
malignant mesothelioma 24 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
ependymoma 21 | 4,679
group 3 medulloblastoma 21 | 4,104
pituitary cancer 20 | 1,972
subependymal giant cell astrocytoma 20 | 2,287
Rheumatoid arthritis 19 | 1,191
Autosomal recessive predisposition 18 | 1,442
breast carcinoma 17 | 1,638
ductal carcinoma in situ 17 | 1,745
Schizophrenia 16 | 1,160
cystic fibrosis 15 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
primary Sjogren syndrome 15 | 735
Asthma 13 | 385
adrenocortical carcinoma 13 | 1,428
colon cancer 13 | 1,478
Arthritis 12 | 290
Obesity 12 | 678
group 4 medulloblastoma 12 | 1,855
nasopharyngeal carcinoma 12 | 1,058
primitive neuroectodermal tumor 12 | 3,035
Human immunodeficiency virus infectious disease 11 | 138
Skin cancer 11 | 469
oligodendroglioma 11 | 2,850
Hypersensitivity reaction type II disease 10 | 253
Inflammatory bowel disease 10 | 151
Melanoma 10 | 711
Multiple Sclerosis 10 | 540
Prostatic Neoplasms 10 | 495
gastric carcinoma 10 | 807
Allergic hypersensitivity disease 9 | 126
Atherosclerosis 9 | 291
Hypertension 9 | 396
Immunologic Deficiency Syndromes 9 | 113
Kidney disease 9 | 430
Liver cancer 9 | 604
Pick disease 9 | 1,894
Systemic lupus erythematosus 9 | 194
Thrombocytopenia 9 | 197
fibroadenoma 9 | 559
Atopic dermatitis 8 | 952
Dermatitis 8 | 157
Diarrhea 8 | 253
Influenza 8 | 142
Lymphoproliferative syndrome 8 | 58
aldosterone-producing adenoma 8 | 665
astrocytic glioma 8 | 2,597
pancreatic carcinoma 8 | 562
Alzheimer's disease 7 | 658
Breast Neoplasms 7 | 445
Chronic Lymphocytic Leukemia 7 | 262
Duchenne muscular dystrophy 7 | 601
Heart disease 7 | 306
Liver disease 7 | 237
Mammary Neoplasms 7 | 425
Pneumonia 7 | 174
non-small cell lung carcinoma 7 | 317
pediatric high grade glioma 7 | 1,064
sarcoidosis 7 | 370
Cerebrovascular disease 6 | 238
Coronary artery disease 6 | 268
Down syndrome 6 | 499
Endometriosis 6 | 540
Failure to gain weight 6 | 365
Hepatomegaly 6 | 285
Lung disease 6 | 142
Pediatric failure to thrive 6 | 365
Vascular disease 6 | 319
active Crohn's disease 6 | 922
astrocytoma 6 | 1,146
head and neck cancer 6 | 271
juvenile dermatomyositis 6 | 1,187
mucosa-associated lymphoid tissue lymphoma 6 | 484
periodontitis 6 | 293

Tissue

Endocrine System 124 | 18,159
Blood and immune system 110 | 16,909
Female tissues 109 | 17,400
Digestive Tract 106 | 17,369
Male tissues 104 | 17,142
Respiratory system 103 | 16,393
Skin and soft tissues 103 | 17,230
Urinary Tract 103 | 16,678
Liver and Pancreas 102 | 16,750
Nervous System 101 | 16,725
Cardiovascular System 96 | 15,192

Target Family

Non-IDG 93 | 12,091
oGPCR 89 | 421
GPCR 9 | 408
Ion Channel 4 | 344
Kinase 4 | 634
Enzyme 2 | 4,145
Transporter 1 | 473

GO Function

transmembrane signaling recept... 202 | 202
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Macrophage receptor MARCO MARCO Tbio Non-IDG -2.37206 210.3 189
Immunoglobulin superfamily member 6 IGSF6 Tbio Non-IDG -1.87882 72.2 146
Integrator complex subunit 6 INTS6 Tbio Non-IDG -2.07240 118.9 80
E-selectin SELE Tchem Non-IDG -3.44926 2672.1 919
Thrombopoietin receptor MPL Tclin Non-IDG -2.74303 582.0 186
Lymphatic vessel endothelial hyaluronic acid receptor 1 LYVE1 Tbio Non-IDG -2.77184 557.5 586
Olfactory receptor 2A25 OR2A25 Tdark oGPCR 0.00000 44
B-cell antigen receptor complex-associated protein beta chain CD79B Tbio Non-IDG -2.54957 343.5 681
Platelet glycoprotein VI GP6 Tbio Non-IDG -2.73714 584.5 201