Development Level

Tbio 9 | 11,445
Tchem 7 | 1,598

IMPC Phenotype

abnormal sleep behavior 1 | 70
increased vertical activity 1 | 24
persistence of hyaloid vascula... 1 | 33
prolonged ST segment 1 | 36

Disease

Carcinoma 15 | 11,493
ovarian cancer 12 | 8,520
medulloblastoma, large-cell 11 | 6,241
Kidney cancer 10 | 2,613
lung cancer 10 | 4,740
non-small cell lung cancer 10 | 2,890
interstitial cystitis 9 | 2,312
osteosarcoma 9 | 7,950
ependymoma 8 | 4,679
adult high grade glioma 7 | 3,801
glioblastoma 7 | 5,792
group 3 medulloblastoma 7 | 4,104
malignant mesothelioma 7 | 3,232
atypical teratoid / rhabdoid tumor 6 | 5,112
pituitary cancer 6 | 1,972
psoriasis 6 | 6,694
ulcerative colitis 6 | 1,819
Astrocytoma, Pilocytic 5 | 3,081
Breast cancer 5 | 3,578
Melanoma 5 | 711
Skin cancer 5 | 469
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
subependymal giant cell astrocytoma 5 | 2,287
Schizophrenia 4 | 1,160
astrocytic glioma 4 | 2,597
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
Autosomal recessive predisposition 3 | 1,442
Cancer 3 | 2,499
Endometrial cancer 3 | 311
Kidney disease 3 | 430
Liver Cirrhosis, Experimental 3 | 769
Pick disease 3 | 1,894
Type 2 diabetes mellitus 3 | 272
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
aldosterone-producing adenoma 3 | 665
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
ductal carcinoma in situ 3 | 1,745
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 807
medulloblastoma 3 | 720
tuberculosis 3 | 2,010
Chronic Lymphocytic Leukemia 2 | 262
Chronic obstructive pulmonary disease 2 | 184
Cognitive disorder 2 | 50
Globe disease 2 | 67
Hyperkalemic periodic paralysis 2 | 9
Liver cancer 2 | 604
Multiple Sclerosis 2 | 540
Stomach Neoplasms 2 | 300
acute myeloid leukemia 2 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
fibroadenoma 2 | 559
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
juvenile dermatomyositis 2 | 1,187
nasopharyngeal carcinoma 2 | 1,058
nephrosclerosis 2 | 333
primary Sjogren syndrome 2 | 735
primary pancreatic ductal adenocarcinoma 2 | 1,109
Amyotrophic lateral sclerosis 1 | 451
Anemia 1 | 365
Corneal disease 1 | 31
Diarrhea 1 | 253
Disease Progression 1 | 136
Focal glomerulosclerosis 1 | 37
Heart conduction disease 1 | 83
Heart disease 1 | 306
Helicobacter Infections 1 | 5
Helicobacter pylori infection, susceptibility to 1 | 2
Highly variable severity 1 | 157
Hypoalbuminemia 1 | 24
Inflammatory bowel disease 1 | 151
Large intestine cancer 1 | 126
Liver neoplasms 1 | 130
Lung disease 1 | 142
Major Depressive Disorder 1 | 301
Mesothelioma, Malignant 1 | 105
Peripheral vascular disease 1 | 87
Proteinuria 1 | 144
Psychotic Disorders 1 | 151
Refractive error 1 | 50
Retinal Diseases 1 | 55
Unipolar Depression 1 | 250
Variable expressivity 1 | 157
active ulcerative colitis 1 | 764
atypical teratoid/rhabdoid tumor 1 | 357
cystic fibrosis and chronic rhinosinusitis 1 | 214
head and neck cancer 1 | 271
severe Alzheimer's disease 1 | 47

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Cardiovascular System 15 | 15,192

Target Family

Enzyme 16 | 4,145

GO Function

transmembrane receptor protein... 16 | 16
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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