Development Level

Tclin 14 | 613
Tchem 11 | 1,598
Tbio 3 | 11,445

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal eye anterior chamber ... 1 | 9
abnormal pericardium morpholog... 1 | 26
decreased leukocyte cell numbe... 1 | 73
embryonic lethality prior to t... 1 | 278
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 27 | 11,493
Cancer 23 | 2,499
lung cancer 20 | 4,740
ovarian cancer 19 | 8,520
non-small cell lung cancer 18 | 2,890
Kidney cancer 17 | 2,613
psoriasis 17 | 6,694
Breast cancer 15 | 3,578
medulloblastoma, large-cell 15 | 6,241
Renal Cell Carcinoma 14 | 214
osteosarcoma 14 | 7,950
atypical teratoid / rhabdoid tumor 13 | 5,112
glioblastoma 13 | 5,792
lung carcinoma 13 | 2,843
Skin cancer 12 | 469
group 3 medulloblastoma 12 | 4,104
lung adenocarcinoma 12 | 2,716
Gastrointestinal stromal tumor 11 | 62
Melanoma 11 | 711
ulcerative colitis 11 | 1,819
ependymoma 10 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
invasive ductal carcinoma 10 | 2,951
malignant mesothelioma 10 | 3,232
Autosomal recessive predisposition 9 | 1,442
Carcinoma of thyroid 9 | 17
Pancreatic Neuroendocrine Tumor 9 | 45
Papillary thyroid carcinoma 9 | 43
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
pituitary cancer 9 | 1,972
Hamman-Rich syndrome 8 | 34
Liver cell carcinoma 8 | 15
adrenocortical carcinoma 8 | 1,428
astrocytic glioma 8 | 2,597
cystic fibrosis 8 | 1,696
Breast Neoplasms 7 | 445
adult high grade glioma 7 | 3,801
breast carcinoma 7 | 1,638
ductal carcinoma in situ 7 | 1,745
pancreatic cancer 7 | 2,398
Follicular thyroid carcinoma 6 | 14
Mammary Neoplasms 6 | 425
Neoplasm Metastasis 6 | 168
interstitial cystitis 6 | 2,312
non-small cell lung carcinoma 6 | 317
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Adenocarcinoma 5 | 122
Astrocytoma, Pilocytic 5 | 3,081
Blastic phase chronic myeloid leukemia 5 | 58
Carcinoma, Non-Small-Cell Lung 5 | 107
Chronic Myelocytic Leukemia Accelerated Phase 5 | 59
Chronic phase chronic myeloid leukemia 5 | 45
Diarrhea 5 | 253
Medullary thyroid carcinoma 5 | 6
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 5 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 5 | 47
Sarcoma of soft tissue 5 | 11
Schizophrenia 5 | 1,160
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Acquired scoliosis 4 | 281
Adenocarcinoma of lung 4 | 142
Adenocarcinoma of lung (disorder) 4 | 60
Atopic dermatitis 4 | 952
Bipolar Disorder 4 | 666
Chronic eosinophilic leukemia 4 | 11
Cognitive delay 4 | 608
Cryptorchidism 4 | 296
Curvature of spine 4 | 282
Disease Progression 4 | 136
Dull intelligence 4 | 645
Exanthem 4 | 37
Global developmental delay 4 | 608
Idiopathic hypereosinophilic syndrome 4 | 10
Intellectual disability 4 | 1,016
Keratitis 4 | 62
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Neoplasm Recurrence, Local 4 | 37
Orbital separation excessive 4 | 244
Poor school performance 4 | 645
Stomach Neoplasms 4 | 300
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
fibroadenoma 4 | 559
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Heart disease 3 | 306
Pectus excavatum 3 | 100
Polycystic ovary syndrome 3 | 360
Posteriorly rotated ear 3 | 61
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
chronic rhinosinusitis 3 | 512
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074

Tissue

Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Male tissues 28 | 17,142
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678
Blood and immune system 27 | 16,909
Nervous System 27 | 16,725
Respiratory system 27 | 16,393
Cardiovascular System 26 | 15,192
Liver and Pancreas 26 | 16,750

Target Family

Kinase 27 | 634
Non-IDG 1 | 12,091

GO Function

transmembrane receptor protein... 28 | 28
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Ephrin type-B receptor 4 EPHB4 Tchem Kinase -2.26622 206.3 514
Tyrosine-protein kinase Mer MERTK Tchem Kinase -2.27276 199.1 609
Epithelial discoidin domain-containing receptor 1 DDR1 Tchem Kinase -2.26801 0.00000 534
ALK tyrosine kinase receptor ALK Tclin Kinase -3.44312 2942.9 976
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953
Insulin receptor-related protein INSRR Tchem Kinase -2.00991 100.4 287
Inactive tyrosine-protein kinase transmembrane receptor ROR1 ROR1 Tbio Kinase -1.38904 30.7 332
Proto-oncogene tyrosine-protein kinase ROS ROS1 Tchem Kinase -2.50073 301.7 343
Mast/stem cell growth factor receptor Kit KIT Tclin Kinase -3.80501 6371.9 4098