Development Level

Tbio 19 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
decreased circulating glucose ... 1 | 126
decreased granulocyte number 1 | 6
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
short tibia 1 | 97

Disease

ovarian cancer 15 | 8,520
Carcinoma 13 | 11,493
lung cancer 13 | 4,740
osteosarcoma 11 | 7,950
medulloblastoma, large-cell 10 | 6,241
malignant mesothelioma 7 | 3,232
psoriasis 7 | 6,694
glioblastoma 6 | 5,792
oligodendroglioma 6 | 2,850
Autosomal recessive predisposition 5 | 1,442
Muscle hypotonia 5 | 571
atypical teratoid / rhabdoid tumor 5 | 5,112
diabetes mellitus 5 | 1,728
group 3 medulloblastoma 5 | 4,104
Epilepsy 4 | 792
Intellectual disability 4 | 1,016
Multiple myeloma 4 | 1,332
Seizures 4 | 596
Short stature 4 | 531
acute quadriplegic myopathy 4 | 1,158
dermatomyositis 4 | 966
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
Big calvaria 3 | 147
Breast cancer 3 | 3,578
Cancer 3 | 2,499
Dull intelligence 3 | 645
Dysarthria 3 | 192
Forgetful 3 | 40
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Lethargy 3 | 77
Low intelligence 3 | 645
Memory Loss 3 | 40
Memory impairment 3 | 40
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Muscle Spasticity 3 | 195
Muscular atrophy 3 | 71
Parkinson's disease 3 | 392
Poor school performance 3 | 645
Premature Menopause 3 | 31
Schizophrenia 3 | 1,160
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
ependymoma 3 | 4,679
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Acquired scoliosis 2 | 281
Adenocarcinoma of lung 2 | 142
Amyotrophic lateral sclerosis 2 | 451
Autistic Disorder 2 | 364
Chronic otitis media 2 | 52
Coarse facial features 2 | 108
Creatine phosphokinase serum increased 2 | 110
Curvature of spine 2 | 282
Decreased tendon reflex 2 | 122
Depressive disorder 2 | 409
Developmental regression 2 | 95
Elevated creatine kinase 2 | 110
Gait Ataxia 2 | 51
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hyperreflexia 2 | 209
Infantile onset 2 | 238
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Loss of developmental milestones 2 | 95
Macrotia 2 | 87
Major Depressive Disorder 2 | 301
Mental deterioration in childhood 2 | 95
Mood Disorders 2 | 184
Neurodegenerative disease 2 | 414
Neurodevelopmental regression 2 | 95
Personality change 2 | 23
Phenotypic variability 2 | 150
Prominent ear 2 | 56
Protruding ears 2 | 56
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Secondary physiologic amenorrhea 2 | 32
Thickened facial skin with coarse facial features 2 | 108
Unipolar Depression 2 | 250
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
hereditary spastic paraplegia 2 | 318
lung adenocarcinoma 2 | 2,716
mucosa-associated lymphoid tissue lymphoma 2 | 484

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Non-IDG 14 | 12,091
Enzyme 5 | 4,145
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Function

translation initiation factor ... 21 | 21
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic translation initiation factor 3 subunit C EIF3C Tbio Non-IDG -1.20680 14.1 159
Eukaryotic translation initiation factor 3 subunit B EIF3B Tbio Non-IDG -1.83618 70.5 84
Translation initiation factor eIF-2B subunit delta EIF2B4 Tbio Non-IDG -1.06082 11.3 145
GTP cyclohydrolase 1 GCH1 Tbio Enzyme -2.80099 639.3 247
Nucleoporin GLE1 GLE1 Tbio Non-IDG -2.24700 173.6 150
Transducin beta-like protein 2 TBL2 Tbio Non-IDG -1.00878 10.8 139
Eukaryotic translation initiation factor 3 subunit C-like protein EIF3CL Tdark Non-IDG 0.00000 13
40S ribosomal protein S24 RPS24 Tbio Non-IDG -1.91732 77.3 92
ATP-dependent RNA helicase DDX3X DDX3X Tchem Enzyme -2.32036 221.7 479
Zinc finger protein ZPR1 ZPR1 Tbio Non-IDG -1.41153 28.2 201