Development Level

Tbio 44 | 11,445
Tdark 4 | 6,588
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
decreased bone mineral content 2 | 151
abnormal behavioral response t... 1 | 66
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal neural tube closure 1 | 46
abnormal spleen morphology 1 | 55
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased granulocyte number 1 | 6
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
increased urine magnesium leve... 1 | 2
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

ovarian cancer 39 | 8,520
Carcinoma 25 | 11,493
osteosarcoma 22 | 7,950
Multiple myeloma 21 | 1,332
lung cancer 20 | 4,740
medulloblastoma, large-cell 17 | 6,241
psoriasis 16 | 6,694
glioblastoma 14 | 5,792
atypical teratoid / rhabdoid tumor 12 | 5,112
Breast cancer 11 | 3,578
Waldenstrons macroglobulinemia 11 | 765
Cancer 10 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
diabetes mellitus 9 | 1,728
group 3 medulloblastoma 9 | 4,104
oligodendroglioma 9 | 2,850
acute quadriplegic myopathy 8 | 1,158
Kidney cancer 7 | 2,613
Leukoencephalopathy with vanishing white matter 7 | 20
astrocytic glioma 7 | 2,597
dermatomyositis 7 | 966
ependymoma 7 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
non-small cell lung cancer 7 | 2,890
hereditary spastic paraplegia 6 | 318
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
malignant mesothelioma 6 | 3,232
primitive neuroectodermal tumor 6 | 3,035
subependymal giant cell astrocytoma 6 | 2,287
Autosomal recessive predisposition 5 | 1,442
Big calvaria 5 | 147
Brain hypomyelination 5 | 11
Central nervous system demyelination 5 | 28
Cessation of head growth 5 | 5
Childhood Ataxia with Central Nervous System Hypomyelinization 5 | 6
Decreased serum progesterone 5 | 5
Delusions 5 | 11
Developmental regression 5 | 95
Dysarthria 5 | 192
Epilepsy 5 | 792
Forgetful 5 | 40
Gait, Unsteady 5 | 29
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Lethargy 5 | 77
Leukodystrophy 5 | 55
Leukoencephalopathies 5 | 29
Loss of developmental milestones 5 | 95
Memory Loss 5 | 40
Memory impairment 5 | 40
Mental deterioration in childhood 5 | 95
Mood swings 5 | 77
Muscle Spasticity 5 | 195
Muscle hypotonia 5 | 571
Neurodevelopmental regression 5 | 95
OVARIOLEUKODYSTROPHY 5 | 6
Optic Atrophy 5 | 242
Personality change 5 | 23
Premature Menopause 5 | 31
Primary gonadal insufficiency 5 | 9
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Rheumatoid arthritis 5 | 1,191
Secondary physiologic amenorrhea 5 | 32
Seizures 5 | 596
Vanishing White Matter Leukodystrophy with Ovarian Failure 5 | 5
pancreatic cancer 5 | 2,398
primary pancreatic ductal adenocarcinoma 5 | 1,109
tuberculosis 5 | 2,010
Adenocarcinoma of lung 4 | 142
Amyotrophic lateral sclerosis 4 | 451
Astrocytoma, Pilocytic 4 | 3,081
Pick disease 4 | 1,894
adult high grade glioma 4 | 3,801
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
sonic hedgehog group medulloblastoma 4 | 467
HIV Infections 3 | 102
acute myeloid leukemia 3 | 783
colon cancer 3 | 1,478
gastric carcinoma 3 | 807
hepatocellular carcinoma 3 | 547
invasive ductal carcinoma 3 | 2,951
medulloblastoma 3 | 720
spina bifida 3 | 1,074
tuberculosis and treatment for 3 months 3 | 179
Carcinoma, Hepatocellular 2 | 228
Liver carcinoma 2 | 240
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
juvenile dermatomyositis 2 | 1,187
pancreatic carcinoma 2 | 562

Tissue

Endocrine System 50 | 18,159
Male tissues 50 | 17,142
Nervous System 50 | 16,725
Blood and immune system 49 | 16,909
Cardiovascular System 49 | 15,192
Digestive Tract 49 | 17,369
Female tissues 49 | 17,400
Liver and Pancreas 49 | 16,750
Respiratory system 49 | 16,393
Skin and soft tissues 49 | 17,230
Urinary Tract 49 | 16,678

Target Family

Non-IDG 50 | 12,091
Enzyme 1 | 4,145

GO Function

translation initiation factor ... 51 | 51
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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