Development Level

Tbio 4 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

abnormal cranium morphology 1 | 36
abnormal incisor morphology 1 | 4
abnormal radius morphology 1 | 8
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased total body fat amoun... 1 | 207
increased blood urea nitrogen ... 1 | 48
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 6 | 11,493
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung carcinoma 6 | 2,843
ovarian cancer 6 | 8,520
glioblastoma 5 | 5,792
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
non-small cell lung cancer 5 | 2,890
osteosarcoma 5 | 7,950
Breast cancer 4 | 3,578
Cancer 4 | 2,499
breast carcinoma 4 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
pancreatic cancer 4 | 2,398
psoriasis 4 | 6,694
Epilepsy 3 | 792
Hereditary hemorrhagic telangiectasia 3 | 13
Hypertensive disease 3 | 292
Hypoplastic mandible condyle 3 | 275
Hypotrophic malar bone 3 | 129
Increase in blood pressure 3 | 119
Intermittent migraine headaches 3 | 68
Liver Cirrhosis 3 | 181
Malar flattening 3 | 129
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Migraine Disorders 3 | 76
Orbital separation excessive 3 | 244
Seizures 3 | 596
acute quadriplegic myopathy 3 | 1,158
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 4,679
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
malignant mesothelioma 3 | 3,232
primary pancreatic ductal adenocarcinoma 3 | 1,109
ANEURYSM, INTRACRANIAL BERRY, 1 (disorder) 2 | 3
Angiodysplasia 2 | 5
Angioectasias of the lip 2 | 4
Angioectasias of the tongue 2 | 2
Arachnodactyly 2 | 49
Arteriovenous Malformations, Cerebral 2 | 2
Arteriovenous malformation 2 | 6
Arteriovenous malformation of liver 2 | 2
Atypical scarring of skin 2 | 62
Blue sclera 2 | 32
Brain Abscess 2 | 2
Brain hemorrhage 2 | 14
COPD 2 | 118
Cardiomegaly 2 | 116
Cerebral Hemorrhage 2 | 42
Chest Pain 2 | 38
Cholecystitis 2 | 18
Clubbing 2 | 9
Conjunctival telangiectasis 2 | 14
Cyanosis 2 | 17
Dyspnea 2 | 76
Epistaxis 2 | 43
Erythrocytosis 2 | 8
Familial primary pulmonary hypertension 2 | 11
Feces color: tarry 2 | 2
Finger pad telangiectases 2 | 2
Flexion contracture of proximal interphalangeal joint 2 | 75
Gastrointestinal angiodysplasia 2 | 3
Gastrointestinal arteriovenous malformation 2 | 2
Gastrointestinal telangiectasia 2 | 2
Gaucher disease type 1 2 | 180
Hemangioma, Cavernous 2 | 20
Hematemesis 2 | 4
Hematochezia 2 | 9
Hemoglobin low 2 | 124
Hernia, Inguinal 2 | 89
Hypertension, Portal 2 | 22
Iron-Refractory Iron Deficiency Anemia 2 | 15
Ischemic stroke 2 | 4
Lip telangiectases 2 | 4
Liver Cirrhosis, Experimental 2 | 769
Melena 2 | 2
Nail bed telangiectases 2 | 2
Nasal mucosa telangiectasia 2 | 2
Palatal spider veins 2 | 2
Palate telangiectases 2 | 2
Polycythemia 2 | 25
Primary pulmonary hypertension 2 | 14
Pulmonary arteriovenous malformation 2 | 2
Retrognathia 2 | 54
Right to left cardiovascular shunt (finding) 2 | 3
Skull malformation 2 | 38
Spider veins of the lip 2 | 4
Spinal arteriovenous malformation 2 | 2
Spontaneous haematoma 2 | 8
Spontaneous, recurrent epistaxis 2 | 3
Subarachnoid Hemorrhage 2 | 7
Telangiectasia of the skin 2 | 39
Telangiectasis 2 | 36
Tongue telangiectasia 2 | 2
Transient Cerebral Ischemia 2 | 25
Visceral angiomatosis 2 | 13

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Non-IDG 4 | 12,091
Kinase 3 | 634

GO Function

transforming growth factor bet... 7 | 7
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Serine/threonine-protein kinase receptor R3 ACVRL1 Tchem Kinase -2.98370 969.8 432
TGF-beta receptor type-1 TGFBR1 Tchem Kinase -2.94747 847.9 413
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
Transforming growth factor beta receptor type 3 TGFBR3 Tbio Non-IDG -1.92250 80.6 270
Latent-transforming growth factor beta-binding protein 4 LTBP4 Tbio Non-IDG -1.55113 39.1 57