Development Level

Tbio 14 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal cranium morphology 1 | 36
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal radius morphology 1 | 8
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
absent vibrissae 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 14 | 8,520
Carcinoma 13 | 11,493
osteosarcoma 13 | 7,950
Cancer 11 | 2,499
psoriasis 11 | 6,694
Breast cancer 10 | 3,578
glioblastoma 10 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
lung adenocarcinoma 9 | 2,716
lung carcinoma 9 | 2,843
non-small cell lung cancer 9 | 2,890
ependymoma 8 | 4,679
invasive ductal carcinoma 8 | 2,951
pancreatic cancer 8 | 2,398
cystic fibrosis 7 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
primary pancreatic ductal adenocarcinoma 7 | 1,109
Astrocytoma, Pilocytic 6 | 3,081
atypical teratoid / rhabdoid tumor 6 | 5,112
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
medulloblastoma, large-cell 6 | 6,241
Hypertensive disease 5 | 292
Kidney cancer 5 | 2,613
acute quadriplegic myopathy 5 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
interstitial cystitis 5 | 2,312
malignant mesothelioma 5 | 3,232
tuberculosis 5 | 2,010
Coronary artery disease 4 | 268
Increase in blood pressure 4 | 119
Liver Cirrhosis 4 | 181
Liver Cirrhosis, Experimental 4 | 769
Orbital separation excessive 4 | 244
active ulcerative colitis 4 | 764
adrenocortical carcinoma 4 | 1,428
adult high grade glioma 4 | 3,801
diabetes mellitus 4 | 1,728
juvenile dermatomyositis 4 | 1,187
lung cancer 4 | 4,740
mucosa-associated lymphoid tissue lymphoma 4 | 484
Abnormality of the iris 3 | 14
Acquired flat foot 3 | 72
Acquired scoliosis 3 | 281
Aortic Valve Insufficiency 3 | 40
Aortic aneurysm, familial thoracic 3 3 | 13
Arachnodactyly 3 | 49
Ascending aortic dissection 3 | 13
Autosomal recessive predisposition 3 | 1,442
Blue sclera 3 | 32
Breast Neoplasms 3 | 445
Byzanthine arch palate 3 | 194
Cardiomegaly 3 | 116
Cerebral Hemorrhage 3 | 42
Chest Pain 3 | 38
Cleft Palate 3 | 271
Cleft uvula 3 | 27
Craniosynostosis 3 | 74
Curvature of spine 3 | 282
Cutis marmorata 3 | 32
Cystic medial necrosis of aorta 3 | 13
Descending aortic dissection 3 | 13
Duchenne muscular dystrophy 3 | 601
Dyspnea on exertion 3 | 24
Dyspnea, Paroxysmal 3 | 13
Epilepsy 3 | 792
Familial thoracic aortic aneurysm and aortic dissection 3 | 13
Flatfoot 3 | 73
Heart disease 3 | 306
Hereditary hemorrhagic telangiectasia 3 | 13
Hernia, Inguinal 3 | 89
Hypertension 3 | 396
Hypoplastic mandible condyle 3 | 275
Hypotrophic malar bone 3 | 129
Impaired left ventricular function 3 | 16
Intermittent migraine headaches 3 | 68
Left-Sided Heart Failure 3 | 16
Loeys-Dietz Aortic Aneurysm Syndrome 3 | 13
Loeys-Dietz syndrome 3 | 23
Malar flattening 3 | 129
Mammary Neoplasms 3 | 425
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Migraine Disorders 3 | 76
Osteoarthritis 3 | 184
Retrognathia 3 | 54
Seizures 3 | 596
Tall stature 3 | 34
active Crohn's disease 3 | 922
astrocytoma 3 | 1,146
group 4 medulloblastoma 3 | 1,855
nasopharyngeal carcinoma 3 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
ulcerative colitis 3 | 1,819
Craniofacial Abnormalities 2 | 151
Epistaxis 2 | 43
Transient Cerebral Ischemia 2 | 25

Tissue

Female tissues 19 | 17,400
Nervous System 19 | 16,725
Respiratory system 19 | 16,393
Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 14 | 12,091
Kinase 4 | 634
Enzyme 1 | 4,145

GO Function

transforming growth factor bet... 19 | 19
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
Twisted gastrulation protein homolog 1 TWSG1 Tbio Non-IDG -2.47209 291.9 79
Latent-transforming growth factor beta-binding protein 4 LTBP4 Tbio Non-IDG -1.55113 39.1 57
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 WFIKKN2 Tbio Non-IDG -0.70376 4.95 94
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Transforming growth factor beta receptor type 3 TGFBR3 Tbio Non-IDG -1.92250 80.6 270
Latent-transforming growth factor beta-binding protein 3 LTBP3 Tbio Non-IDG -3.14299 1230.0 4
Hyaluronidase-2 HYAL2 Tbio Enzyme -2.01424 105.1 212