Development Level

Tbio 51 | 11,445
Tdark 14 | 6,588
Tchem 4 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

decreased bone mineral density 3 | 126
increased fasted circulating g... 2 | 76
abnormal allantois morphology 1 | 8
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal skin morphology 1 | 50
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal vibrissa morphology 1 | 25
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
bleb 1 | 2
brachydactyly 1 | 19
cataract 1 | 92
decreased B cell number 1 | 5
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating phosphat... 1 | 27
decreased fasted circulating g... 1 | 65
decreased respiratory quotient 1 | 16
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged spleen 1 | 41
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating calcium ... 1 | 34
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
male infertility 1 | 123
pale yolk sac 1 | 25
preweaning lethality, complete... 1 | 979
scaly skin 1 | 4
syndactyly 1 | 23

Disease

Carcinoma 44 | 11,493
ovarian cancer 38 | 8,520
osteosarcoma 27 | 7,950
medulloblastoma, large-cell 19 | 6,241
psoriasis 16 | 6,694
atypical teratoid / rhabdoid tumor 15 | 5,112
glioblastoma 15 | 5,792
lung cancer 15 | 4,740
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
ependymoma 12 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
adult high grade glioma 11 | 3,801
malignant mesothelioma 11 | 3,232
pancreatic cancer 11 | 2,398
group 3 medulloblastoma 10 | 4,104
lung carcinoma 10 | 2,843
Breast cancer 9 | 3,578
Kidney cancer 9 | 2,613
group 4 medulloblastoma 9 | 1,855
invasive ductal carcinoma 9 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
tuberculosis 9 | 2,010
Multiple myeloma 8 | 1,332
juvenile dermatomyositis 8 | 1,187
oligodendroglioma 8 | 2,850
Intellectual disability 7 | 1,016
Waldenstrons macroglobulinemia 7 | 765
interstitial cystitis 7 | 2,312
primitive neuroectodermal tumor 7 | 3,035
Pick disease 6 | 1,894
Rheumatoid arthritis 6 | 1,191
active ulcerative colitis 6 | 764
cutaneous lupus erythematosus 6 | 1,057
dermatomyositis 6 | 966
non-small cell lung cancer 6 | 2,890
pituitary cancer 6 | 1,972
Astrocytoma, Pilocytic 5 | 3,081
Cancer 5 | 2,499
Duchenne muscular dystrophy 5 | 601
Multiple Sclerosis 5 | 540
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
cystic fibrosis 5 | 1,696
esophageal adenocarcinoma 5 | 737
primary Sjogren syndrome 5 | 735
spina bifida 5 | 1,074
subependymal giant cell astrocytoma 5 | 2,287
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Schizophrenia 4 | 1,160
active Crohn's disease 4 | 922
astrocytoma 4 | 1,146
ductal carcinoma in situ 4 | 1,745
lung adenocarcinoma 4 | 2,716
medulloblastoma 4 | 720
ulcerative colitis 4 | 1,819
Agenesis of corpus callosum 3 | 83
Atopic dermatitis 3 | 952
Breast Neoplasms 3 | 445
Cardiovascular system disease 3 | 246
Dull intelligence 3 | 645
Epilepsy 3 | 792
HIV Infections 3 | 102
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Poor school performance 3 | 645
acute myeloid leukemia 3 | 783
breast carcinoma 3 | 1,638
gastric carcinoma 3 | 807
mucosa-associated lymphoid tissue lymphoma 3 | 484
non primary Sjogren syndrome sicca 3 | 891
pediatric high grade glioma 3 | 1,064
posterior fossa group B ependymoma 3 | 416
Acquired scoliosis 2 | 281
Anemia 2 | 365
Attention deficit hyperactivity disorder 2 | 278
Bipolar Disorder 2 | 666
Curvature of spine 2 | 282
Delayed speech and language development 2 | 112
Language Delay 2 | 112
Leukemia 2 | 104
Lice infestation 2 | 15
Lissencephaly 2 | 69
Liver Cirrhosis, Experimental 2 | 769
Speech Delay 2 | 112
Speech impairment 2 | 112
Strabismus 2 | 270
Type 2 diabetes mellitus 2 | 272
adrenocortical carcinoma 2 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
glioblastoma multiforme 2 | 142
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676

Tissue

Endocrine System 69 | 18,159
Female tissues 67 | 17,400
Liver and Pancreas 66 | 16,750
Digestive Tract 65 | 17,369
Respiratory system 65 | 16,393
Skin and soft tissues 65 | 17,230
Urinary Tract 65 | 16,678
Male tissues 64 | 17,142
Nervous System 64 | 16,725
Blood and immune system 63 | 16,909
Cardiovascular System 61 | 15,192

Target Family

Enzyme 47 | 4,145
Non-IDG 16 | 12,091
Kinase 3 | 634
Epigenetic 2 | 242
Transcription Factor 2 | 1,400

GO Function

transferase activity 70 | 70
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phospholipid-metabolizing enzyme A-C1 HRASLS Tbio Non-IDG -0.89072 8.53 0
Ribosome biogenesis protein TSR3 homolog TSR3 Tdark Non-IDG -0.42233 2.29 16
E3 ubiquitin ligase RNF157 RNF157 Tbio Non-IDG 0.11 1.20 96
Probable E3 ubiquitin-protein ligase MID2 MID2 Tbio Enzyme -2.49198 303.4 152
E3 ubiquitin-protein ligase TRIM50 TRIM50 Tdark Enzyme -0.46630 3.11 109
Probable E3 ubiquitin-protein ligase DTX2 DTX2 Tbio Enzyme -1.74890 58.1 123
Probable E3 ubiquitin-protein ligase TRIML1 TRIML1 Tdark Enzyme 0.21 0.97 97
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
Putative E3 ubiquitin-protein ligase makorin-4 MKRN4P Tdark Enzyme 0.00000 0
E3 ubiquitin-protein ligase MARCH3 MARCH3 Tbio Enzyme -1.44900 27.8 135