Development Level

Tbio 94 | 10,625
Tdark 9 | 7,003
Tchem 6 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, incomple... 5 | 260
increased fasted circulating g... 4 | 68
preweaning lethality, complete... 4 | 633
abnormal behavior 3 | 226
enlarged heart 3 | 111
abnormal retinal pigmentation 2 | 61
decreased body weight 2 | 174
decreased total body fat amoun... 2 | 186
increased bone mineral content 2 | 92
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal eye posterior chamber... 1 | 3
abnormal gait 1 | 51
abnormal optic disc morphology 1 | 10
abnormal sleep behavior 1 | 63
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
aorta dilation 1 | 3
corneal opacity 1 | 25
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 108
decreased cardiac output 1 | 2
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating free fat... 1 | 39
decreased circulating phosphat... 1 | 15
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased mean platelet volume 1 | 12
decreased monocyte cell number 1 | 28
decreased startle reflex 1 | 48
decreased vertical activity 1 | 22
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
improved glucose tolerance 1 | 56
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating iron lev... 1 | 25
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased lean body mass 1 | 107
irregularly shaped pupil 1 | 7
oligodactyly 1 | 14
prenatal lethality 1 | 16
short tibia 1 | 82
small testis 1 | 37
thin ventricular wall 1 | 5
trunk curl 1 | 15

Disease

osteosarcoma 63 | 7,933
ovarian cancer 54 | 8,484
medulloblastoma, large-cell 51 | 6,234
psoriasis 47 | 6,685
glioblastoma 43 | 5,572
lung cancer 42 | 4,466
Cancer 37 | 2,346
atypical teratoid / rhabdoid tumor 34 | 4,369
invasive ductal carcinoma 31 | 2,950
malignant mesothelioma 28 | 3,162
primitive neuroectodermal tumor 28 | 3,031
non-small cell lung cancer 25 | 2,798
pediatric high grade glioma 25 | 2,712
lung adenocarcinoma 24 | 2,713
pilocytic astrocytoma 24 | 3,086
Breast cancer 22 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
pancreatic cancer 22 | 2,300
group 4 medulloblastoma 21 | 1,875
pituitary cancer 21 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,956
lung carcinoma 20 | 2,844
interstitial cystitis 19 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
Carcinoma 18 | 2,147
oligodendroglioma 18 | 2,849
breast carcinoma 17 | 1,614
cystic fibrosis 17 | 1,665
ulcerative colitis 17 | 2,087
ductal carcinoma in situ 16 | 1,745
posterior fossa group A ependymoma 16 | 1,511
subependymal giant cell astrocytoma 16 | 2,287
diabetes mellitus 15 | 1,663
primary pancreatic ductal adenocarcinoma 15 | 1,271
sonic hedgehog group medulloblastoma 15 | 1,482
Pick disease 14 | 1,893
acute quadriplegic myopathy 14 | 1,157
astrocytoma 14 | 1,493
colon cancer 14 | 1,475
group 3 medulloblastoma 14 | 2,254
juvenile dermatomyositis 13 | 1,189
adult high grade glioma 12 | 2,148
cutaneous lupus erythematosus 12 | 1,056
ependymoma 12 | 2,514
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Rheumatoid Arthritis 11 | 1,160
acute myeloid leukemia 11 | 780
adrenocortical carcinoma 10 | 1,427
atypical teratoid/rhabdoid tumor 10 | 1,095
tuberculosis 10 | 1,557
Mammary Neoplasms 9 | 410
aldosterone-producing adenoma 9 | 664
astrocytic glioma 9 | 2,241
gastric carcinoma 9 | 832
posterior fossa group B ependymoma 9 | 1,530
inflammatory breast cancer 8 | 404
medulloblastoma 8 | 1,524
Atopic dermatitis 7 | 944
Diabetes Mellitus, Non-Insulin-Dependent 7 | 157
Intellectual disability 7 | 573
Multiple myeloma 7 | 1,327
Neoplasm Invasiveness 7 | 127
Obesity 7 | 616
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
spina bifida 7 | 1,064
tuberculosis and treatment for 3 months 7 | 327
tuberculosis and treatment for 6 months 7 | 686
Craniofacial Abnormalities 6 | 147
Crohn's disease 6 | 304
Down syndrome 6 | 548
Stomach Neoplasms 6 | 282
Type 2 diabetes mellitus 6 | 189
chronic rhinosinusitis 6 | 512
dermatomyositis 6 | 933
nephrosclerosis 6 | 329
primary Sjogren syndrome 6 | 789
Acquired metabolic disease 5 | 267
Alzheimer's disease 5 | 644
Amyotrophic Lateral Sclerosis 5 | 431
Congenital heart disease 5 | 63
Diabetes Mellitus, Experimental 5 | 106
Hyperglycemia 5 | 120
active Crohn's disease 5 | 918
active ulcerative colitis 5 | 477
fibroadenoma 5 | 557
nasopharyngeal carcinoma 5 | 1,056
nervous system disorder 5 | 53
non primary Sjogren syndrome sicca 5 | 840
sarcoidosis 5 | 358
urothelial carcinoma 5 | 318
Adenoid Cystic Carcinoma 4 | 99
Endometriosis 4 | 535
Glaucoma 4 | 134
Heart disease 4 | 279
Liver carcinoma 4 | 217
Metabolic syndrome X 4 | 155
Prostatic Neoplasms 4 | 471
Waldenstrons macroglobulinemia 4 | 765
gastric cancer 4 | 430
hepatocellular carcinoma 4 | 532

Tissue

Endocrine System 110 | 18,512
Nervous System 110 | 18,561
Blood and immune system 109 | 17,995
Digestive Tract 109 | 18,473
Female tissues 109 | 18,647
Liver and Pancreas 109 | 18,136
Urinary Tract 109 | 18,444
Cardiovascular System 108 | 17,958
Skin and soft tissues 108 | 18,115
Male tissues 107 | 17,969
Respiratory system 107 | 17,484

Target Family

Transcription Factor 86 | 1,400
Non-IDG 14 | 11,971
Nuclear Receptor 5 | 48
Epigenetic 2 | 242
TF/Epigenetic 2 | 38
Ion Channel 1 | 341

GO Function

transcriptional repressor acti... 110 | 110
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373
Erythroid transcription factor GATA1 Tbio Transcription Factor -2.97791 941.1 675
Zinc finger protein 536 ZNF536 Tdark Transcription Factor -0.17194 1.30 69
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
Jun dimerization protein 2 JDP2 Tbio Transcription Factor -1.55991 46.1 62
T-box transcription factor TBX15 TBX15 Tbio Transcription Factor -1.24119 20.1 98
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.02060 88.8 104