Development Level

Tbio 117 | 11,178
Tchem 9 | 1,885
Tdark 8 | 6,569
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 6 | 979
increased bone mineral content 5 | 108
abnormal sleep behavior 3 | 70
enlarged heart 3 | 210
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased erythrocyte cell num... 2 | 62
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
hypoactivity 2 | 132
increased circulating chloride... 2 | 41
increased circulating sodium l... 2 | 71
increased startle reflex 2 | 112
thin ventricular wall 2 | 24
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal optic disc morphology 1 | 10
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
aorta stenosis 1 | 2
corneal opacity 1 | 32
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased cardiac output 1 | 3
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased circulating glycerol... 1 | 16
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
improved glucose tolerance 1 | 79
increased body temperature 1 | 9
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased fluid intake 1 | 1
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
irregularly shaped pupil 1 | 7
microphthalmia 1 | 26
prenatal lethality 1 | 28
prolonged QRS complex duration 1 | 8
short tibia 1 | 97
small spleen 1 | 19
small testis 1 | 58
small thymus 1 | 16
thrombocytopenia 1 | 56
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 92 | 11,192
osteosarcoma 70 | 7,766
ovarian cancer 62 | 8,297
psoriasis 49 | 6,514
medulloblastoma, large-cell 48 | 6,086
lung cancer 46 | 4,607
glioblastoma 44 | 5,635
atypical teratoid / rhabdoid tumor 41 | 4,971
Cancer 38 | 2,388
group 3 medulloblastoma 35 | 4,002
invasive ductal carcinoma 34 | 2,867
adult high grade glioma 32 | 3,701
Breast cancer 31 | 3,469
ependymoma 31 | 4,559
primitive neuroectodermal tumor 28 | 2,957
lung adenocarcinoma 27 | 2,627
malignant mesothelioma 27 | 3,135
Astrocytoma, Pilocytic 26 | 3,006
non-small cell lung cancer 25 | 2,799
pancreatic cancer 24 | 2,322
subependymal giant cell astrocytoma 24 | 2,230
Kidney cancer 23 | 2,548
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,204
lung carcinoma 23 | 2,755
pituitary cancer 23 | 1,915
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,872
oligodendroglioma 20 | 2,768
interstitial cystitis 19 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,911
ulcerative colitis 18 | 1,765
Pick disease 17 | 1,856
acute quadriplegic myopathy 17 | 1,133
astrocytic glioma 17 | 2,530
cystic fibrosis 16 | 1,629
diabetes mellitus 16 | 1,683
ductal carcinoma in situ 16 | 1,686
Schizophrenia 15 | 1,136
breast carcinoma 15 | 1,589
juvenile dermatomyositis 15 | 1,147
colon cancer 14 | 1,428
group 4 medulloblastoma 14 | 1,806
tuberculosis 14 | 1,963
Intellectual disability 13 | 998
Rheumatoid arthritis 13 | 1,156
cutaneous lupus erythematosus 12 | 1,016
Autosomal recessive predisposition 11 | 1,407
Breast Neoplasms 11 | 423
Mammary Neoplasms 11 | 403
Obesity 11 | 655
Short stature 11 | 514
adrenocortical carcinoma 11 | 1,385
astrocytoma 11 | 1,113
Dull intelligence 10 | 634
Low intelligence 10 | 634
Mental Retardation 10 | 634
Mental deficiency 10 | 634
Poor school performance 10 | 634
acute myeloid leukemia 10 | 760
primary pancreatic ductal adenocarcinoma 10 | 1,071
Crohn's disease 9 | 311
Neoplasm Invasiveness 9 | 151
Strabismus 9 | 265
pediatric high grade glioma 9 | 1,035
primary Sjogren syndrome 9 | 710
Alzheimer's disease 8 | 640
Failure to gain weight 8 | 359
Muscle hypotonia 8 | 562
Pediatric failure to thrive 8 | 359
sonic hedgehog group medulloblastoma 8 | 459
spina bifida 8 | 1,053
Atopic dermatitis 7 | 915
Bipolar Disorder 7 | 646
Cognitive delay 7 | 596
Craniofacial Abnormalities 7 | 141
Epilepsy 7 | 775
Global developmental delay 7 | 596
Mental and motor retardation 7 | 596
Multiple myeloma 7 | 1,296
Seizures 7 | 584
Type 2 diabetes mellitus 7 | 268
aldosterone-producing adenoma 7 | 646
dermatomyositis 7 | 941
nasopharyngeal carcinoma 7 | 1,024
Acquired metabolic disease 6 | 329
Amyotrophic lateral sclerosis 6 | 437
Conductive hearing loss 6 | 122
Congenital deafness 6 | 180
Cryptorchidism 6 | 287
Deafness 6 | 193
Hearing Loss, Partial 6 | 180
Osteoporosis 6 | 348
Prostatic Neoplasms 6 | 472
Small head 6 | 366
Stomach Neoplasms 6 | 287
Waldenstrons macroglobulinemia 6 | 742
active ulcerative colitis 6 | 736
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 492
hearing impairment 6 | 194
non primary Sjogren syndrome sicca 6 | 861

Tissue

Endocrine System 133 | 18,159
Digestive Tract 128 | 17,369
Skin and soft tissues 128 | 17,230
Female tissues 126 | 17,400
Urinary Tract 126 | 16,678
Male tissues 125 | 17,142
Nervous System 125 | 16,725
Blood and immune system 124 | 16,909
Liver and Pancreas 124 | 16,750
Respiratory system 121 | 16,393
Cardiovascular System 114 | 15,192

Target Family

Transcription Factor 110 | 1,400
Non-IDG 12 | 12,091
Nuclear Receptor 7 | 48
Epigenetic 2 | 242
TF/Epigenetic 2 | 38
Enzyme 1 | 4,145
Ion Channel 1 | 344

GO Function

transcriptional repressor acti... 135 | 135
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 239 ZNF239 Tbio Transcription Factor -0.89117 8.77 88
Nuclear receptor subfamily 1 group D member 1 NR1D1 Tchem Nuclear Receptor -1.95952 81.6 389
Homeobox protein engrailed-1 EN1 Tbio Transcription Factor -2.44551 264.6 188
Gamma-interferon-inducible protein 16 IFI16 Tbio Non-IDG -1.96972 112.7 246
Transcription factor Sp2 SP2 Tbio Transcription Factor -2.91429 774.4 137
Zinc finger protein 90 homolog ZFP90 Tbio Transcription Factor -1.22318 15.8 54
Homeobox protein Nkx-3.2 NKX3-2 Tbio Transcription Factor -1.63808 48.5 142
Alpha-enolase ENO1 Tchem Enzyme -2.83087 656.7 508
Sal-like protein 1 SALL1 Tbio Transcription Factor -2.58811 380.7 143
Forkhead box protein Q1 FOXQ1 Tbio Transcription Factor -1.59265 41.7 364