Development Level

Tbio 118 | 11,445
Tchem 12 | 1,598
Tdark 7 | 6,588
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased vertical activity 4 | 208
abnormal eye morphology 3 | 68
abnormal retina morphology 3 | 71
decreased lymphocyte cell numb... 3 | 83
decreased total body fat amoun... 3 | 207
increased or absent threshold ... 3 | 101
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal facial morphology 2 | 17
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased circulating triglyce... 2 | 79
decreased prepulse inhibition 2 | 82
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hypoactivity 2 | 132
increased circulating sodium l... 2 | 71
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
prenatal lethality prior to he... 2 | 87
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal epididymis morphology 1 | 42
abnormal eyelid morphology 1 | 7
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal ovary morphology 1 | 7
abnormal placenta morphology 1 | 5
abnormal retinal inner nuclear... 1 | 8
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal tail morphology 1 | 25
abnormal thymus morphology 1 | 7
absent epididymis 1 | 3
absent vibrissae 1 | 12
aorta stenosis 1 | 2
athymia 1 | 2
cleft palate 1 | 8
corneal opacity 1 | 32
corneal vascularization 1 | 6
cyanosis 1 | 7
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
eyelids fail to open 1 | 3
hemorrhage 1 | 23
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 89 | 11,493
psoriasis 71 | 6,694
osteosarcoma 67 | 7,950
ovarian cancer 59 | 8,520
Cancer 47 | 2,499
medulloblastoma, large-cell 46 | 6,241
Breast cancer 42 | 3,578
glioblastoma 41 | 5,792
lung cancer 41 | 4,740
atypical teratoid / rhabdoid tumor 36 | 5,112
ependymoma 31 | 4,679
group 3 medulloblastoma 30 | 4,104
invasive ductal carcinoma 30 | 2,951
malignant mesothelioma 29 | 3,232
adult high grade glioma 27 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
non-small cell lung cancer 26 | 2,890
lung adenocarcinoma 24 | 2,716
interstitial cystitis 23 | 2,312
Astrocytoma, Pilocytic 22 | 3,081
Rheumatoid arthritis 22 | 1,191
breast carcinoma 22 | 1,638
ductal carcinoma in situ 22 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
oligodendroglioma 20 | 2,850
pituitary cancer 20 | 1,972
pancreatic cancer 19 | 2,398
ulcerative colitis 19 | 1,819
lung carcinoma 18 | 2,843
primitive neuroectodermal tumor 18 | 3,035
diabetes mellitus 17 | 1,728
astrocytic glioma 16 | 2,597
group 4 medulloblastoma 16 | 1,855
spina bifida 16 | 1,074
Kidney cancer 15 | 2,613
subependymal giant cell astrocytoma 15 | 2,287
Intellectual disability 14 | 1,016
adrenocortical carcinoma 14 | 1,428
astrocytoma 14 | 1,146
colon cancer 14 | 1,478
cutaneous lupus erythematosus 14 | 1,057
Autosomal recessive predisposition 13 | 1,442
Cleft Palate 13 | 271
Prostatic Neoplasms 13 | 495
Short stature 13 | 531
Multiple myeloma 12 | 1,332
Pick disease 12 | 1,894
acute quadriplegic myopathy 12 | 1,158
Obesity 11 | 678
cystic fibrosis 11 | 1,696
dermatomyositis 11 | 966
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Craniofacial Abnormalities 10 | 151
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
juvenile dermatomyositis 10 | 1,187
Atopic dermatitis 9 | 952
Broad flat nasal bridge 9 | 236
Cognitive delay 9 | 608
Cryptorchidism 9 | 296
Global developmental delay 9 | 608
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Mental and motor retardation 9 | 608
Micrognathism 9 | 275
Nasal bridge wide 9 | 236
aldosterone-producing adenoma 9 | 665
gastric carcinoma 9 | 807
primary pancreatic ductal adenocarcinoma 9 | 1,109
tuberculosis 9 | 2,010
Bilateral fifth finger clinodactyly 8 | 110
Curvature of little finger 8 | 110
Immune system cancer 8 | 140
Ventricular Septal Defects 8 | 119
Waldenstrons macroglobulinemia 8 | 765
acute myeloid leukemia 8 | 783
esophageal adenocarcinoma 8 | 737
Acquired scoliosis 7 | 281
Anemia 7 | 365
Asthma 7 | 385
Bipolar Disorder 7 | 666
Crohn's disease 7 | 321
Curvature of spine 7 | 282
Down syndrome 7 | 499
Fetal Growth Retardation 7 | 189
Infant, Small for Gestational Age 7 | 176
Intrauterine retardation 7 | 176
Mental Depression 7 | 333
Muscle hypotonia 7 | 571
Schizophrenia 7 | 1,160
Stomach Neoplasms 7 | 300
Uranostaphyloschisis 7 | 167
Vascular disease 7 | 319
fibroadenoma 7 | 559
hepatocellular carcinoma 7 | 547
primary Sjogren syndrome 7 | 735

Tissue

Endocrine System 130 | 18,159
Digestive Tract 129 | 17,369
Skin and soft tissues 124 | 17,230
Female tissues 123 | 17,400
Male tissues 123 | 17,142
Blood and immune system 115 | 16,909
Nervous System 115 | 16,725
Liver and Pancreas 114 | 16,750
Urinary Tract 113 | 16,678
Respiratory system 106 | 16,393
Cardiovascular System 92 | 15,192

Target Family

Transcription Factor 117 | 1,400
Non-IDG 11 | 12,091
Nuclear Receptor 7 | 48
TF/Epigenetic 2 | 38
Enzyme 1 | 4,145
Epigenetic 1 | 242

GO Function

transcriptional activator acti... 139 | 139
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Doublesex- and mab-3-related transcription factor 1 DMRT1 Tbio Transcription Factor -2.31269 210.5 197
ETS-related transcription factor Elf-5 ELF5 Tbio Transcription Factor -1.72839 58.0 200
Zinc finger protein 300 ZNF300 Tbio Transcription Factor -0.81482 8.21 85
Photoreceptor-specific nuclear receptor NR2E3 Tbio Nuclear Receptor 0.00000 261
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 SOHLH2 Tbio Transcription Factor -1.26578 21.4 126
BarH-like 2 homeobox protein BARHL2 Tbio Transcription Factor -0.91713 9.51 53
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Transcription factor Ovo-like 2 OVOL2 Tbio Transcription Factor -1.20117 17.4 110
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298