Development Level

Tbio 25 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
embryonic lethality prior to t... 2 | 278
increased fasted circulating g... 2 | 76
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal response to new envir... 1 | 10
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal tooth morphology 1 | 24
absent ovary 1 | 3
absent startle reflex 1 | 24
absent vibrissae 1 | 12
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
hemorrhage 1 | 23
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
tremors 1 | 39

Disease

osteosarcoma 18 | 7,950
Carcinoma 15 | 11,493
psoriasis 14 | 6,694
ovarian cancer 13 | 8,520
lung cancer 12 | 4,740
glioblastoma 11 | 5,792
medulloblastoma, large-cell 11 | 6,241
Cancer 10 | 2,499
atypical teratoid / rhabdoid tumor 10 | 5,112
lung carcinoma 8 | 2,843
Kidney cancer 6 | 2,613
Muscle hypotonia 6 | 571
colon cancer 6 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
primitive neuroectodermal tumor 6 | 3,035
Breast cancer 5 | 3,578
Intellectual disability 5 | 1,016
astrocytoma 5 | 1,146
dermatomyositis 5 | 966
diabetes mellitus 5 | 1,728
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
group 4 medulloblastoma 5 | 1,855
invasive ductal carcinoma 5 | 2,951
non-small cell lung cancer 5 | 2,890
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Astrocytoma, Pilocytic 4 | 3,081
Congenital heart disease 4 | 93
Epilepsy 4 | 792
Liver Cirrhosis, Experimental 4 | 769
Multiple myeloma 4 | 1,332
Parkinson's disease 4 | 392
malignant mesothelioma 4 | 3,232
pediatric high grade glioma 4 | 1,064
primary Sjogren syndrome 4 | 735
Acquired metabolic disease 3 | 336
Amyotrophic lateral sclerosis 3 | 451
Autosomal recessive predisposition 3 | 1,442
Brachycephaly 3 | 88
Broad cranium shape 3 | 88
Cell Transformation, Neoplastic 3 | 97
Cognitive delay 3 | 608
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Down syndrome 3 | 499
Dull intelligence 3 | 645
Global developmental delay 3 | 608
Heat Stroke 3 | 13
Holoprosencephaly 3 | 56
Hypoplasia of corpus callosum 3 | 90
Liver cancer 3 | 604
Liver neoplasms 3 | 130
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Microphthalmia 3 | 76
Neoplastic Cell Transformation 3 | 89
Osteoporosis 3 | 363
Poor school performance 3 | 645
Schizophrenia 3 | 1,160
Short stature 3 | 531
Small head 3 | 374
Wide skull shape 3 | 88
acute myeloid leukemia 3 | 783
adult high grade glioma 3 | 3,801
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
ductal carcinoma in situ 3 | 1,745
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
Alzheimer's disease 2 | 658
Brain Ischemia 2 | 110
Cholestasis 2 | 155
Colonic Neoplasms 2 | 142
Dementia 2 | 175
Endometrial cancer 2 | 311
Liver Cirrhosis 2 | 181
Liver carcinoma 2 | 240
Microcephaly 2 | 166
Motor delay 2 | 147
Neoplasm Invasiveness 2 | 161
Seizures 2 | 596
Toxic encephalopathy 2 | 141
Ventricular Septal Defects 2 | 119
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
head and neck cancer 2 | 271
lung adenocarcinoma 2 | 2,716
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
progressive supranuclear palsy 2 | 676

Tissue

Endocrine System 28 | 18,159
Digestive Tract 27 | 17,369
Skin and soft tissues 27 | 17,230
Blood and immune system 26 | 16,909
Female tissues 26 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Urinary Tract 24 | 16,678
Cardiovascular System 22 | 15,192

Target Family

Transcription Factor 26 | 1,400
Non-IDG 2 | 12,091
Nuclear Receptor 1 | 48

GO Function

transcriptional activator acti... 29 | 29
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Steroid hormone receptor ERR2 ESRRB Tchem Nuclear Receptor -1.95523 86.9 173
Activated RNA polymerase II transcriptional coactivator p15 SUB1 Tbio Transcription Factor -2.45222 273.0 173
AT-rich interactive domain-containing protein 3B ARID3B Tbio Transcription Factor -1.00150 12.8 149
Transcription factor Spi-B SPIB Tbio Transcription Factor -1.80629 65.0 120
POU domain, class 4, transcription factor 1 POU4F1 Tbio Transcription Factor -2.19846 154.8 107
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.84150 362.9 46
Homeobox protein MOX-2 MEOX2 Tbio Transcription Factor -2.20760 167.0 293
Pre-B-cell leukemia transcription factor 3 PBX3 Tbio Transcription Factor -1.58292 36.0 183
Homeobox protein prophet of Pit-1 PROP1 Tbio Transcription Factor -2.15448 151.2 67