Development Level

Tbio 245 | 11,651
Tchem 21 | 1,388
Tclin 6 | 612
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, complete... 14 | 979
preweaning lethality, incomple... 10 | 499
abnormal embryo size 8 | 220
enlarged heart 8 | 210
decreased vertical activity 7 | 208
embryonic lethality prior to t... 7 | 278
abnormal heart morphology 6 | 162
embryonic growth retardation 6 | 106
abnormal bone structure 5 | 187
abnormal seminal vesicle morph... 5 | 114
increased startle reflex 5 | 112
prenatal lethality prior to he... 5 | 87
abnormal behavior 4 | 298
decreased total body fat amoun... 4 | 207
increased circulating alkaline... 4 | 122
male infertility 4 | 123
abnormal forebrain development 3 | 20
abnormal hindbrain development 3 | 16
abnormal neural tube closure 3 | 46
decreased body weight 3 | 161
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
female infertility 3 | 60
increased lean body mass 3 | 172
increased monocyte cell number 3 | 63
increased total body fat amoun... 3 | 134
small superior vagus ganglion 3 | 74
abnormal cornea morphology 2 | 31
abnormal craniofacial morpholo... 2 | 33
abnormal epididymis morphology 2 | 42
abnormal facial morphology 2 | 17
abnormal heart left ventricle ... 2 | 16
abnormal midbrain development 2 | 20
abnormal ovary morphology 2 | 7
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
absent epididymis 2 | 3
absent seminal vesicle 2 | 4
anophthalmia 2 | 33
corneal opacity 2 | 32
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased circulating chloride... 2 | 30
decreased circulating choleste... 2 | 93
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
hemorrhage 2 | 23
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased cardiac muscle contr... 2 | 8
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased lactate dehydrogenas... 2 | 3
increased or absent threshold ... 2 | 101
microphthalmia 2 | 26
short tibia 2 | 97
small uterus 2 | 3
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal heart looping 1 | 5
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
absent spleen 1 | 3
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased mean platelet volume 1 | 25
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased exploration in new e... 1 | 8
increased heart weight 1 | 62
increased vertical activity 1 | 24
long tibia 1 | 25
prenatal lethality 1 | 28

Disease

Carcinoma 180 | 11,493
ovarian cancer 149 | 8,520
osteosarcoma 132 | 7,950
psoriasis 123 | 6,694
Cancer 111 | 2,499
medulloblastoma, large-cell 109 | 6,241
glioblastoma 102 | 5,792
lung cancer 97 | 4,740
Breast cancer 80 | 3,578
atypical teratoid / rhabdoid tumor 79 | 5,112
ependymoma 75 | 4,679
malignant mesothelioma 68 | 3,232
group 3 medulloblastoma 65 | 4,104
non-small cell lung cancer 65 | 2,890
adult high grade glioma 60 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 59 | 3,291
invasive ductal carcinoma 55 | 2,951
primitive neuroectodermal tumor 55 | 3,035
pancreatic cancer 54 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,989
interstitial cystitis 50 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,955
pituitary cancer 46 | 1,972
lung adenocarcinoma 45 | 2,716
lung carcinoma 45 | 2,843
ductal carcinoma in situ 44 | 1,745
oligodendroglioma 43 | 2,850
group 4 medulloblastoma 42 | 1,855
ulcerative colitis 41 | 1,819
Astrocytoma, Pilocytic 38 | 3,081
breast carcinoma 38 | 1,638
subependymal giant cell astrocytoma 38 | 2,287
astrocytic glioma 36 | 2,597
Rheumatoid arthritis 34 | 1,191
diabetes mellitus 32 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,962
cystic fibrosis 31 | 1,696
astrocytoma 30 | 1,146
Obesity 29 | 678
Intellectual disability 28 | 1,016
Short stature 27 | 531
adrenocortical carcinoma 27 | 1,428
colon cancer 27 | 1,478
pediatric high grade glioma 27 | 1,064
tuberculosis 27 | 2,010
Schizophrenia 26 | 1,160
primary pancreatic ductal adenocarcinoma 26 | 1,109
Autosomal recessive predisposition 25 | 1,442
cutaneous lupus erythematosus 25 | 1,057
Kidney cancer 24 | 2,613
Breast Neoplasms 22 | 445
Multiple myeloma 22 | 1,332
acute quadriplegic myopathy 22 | 1,158
juvenile dermatomyositis 22 | 1,187
non primary Sjogren syndrome sicca 22 | 891
Bipolar Disorder 21 | 666
Dull intelligence 21 | 645
Low intelligence 21 | 645
Mental Retardation 21 | 645
Mental deficiency 21 | 645
Pick disease 21 | 1,894
Poor school performance 21 | 645
Prostatic Neoplasms 21 | 495
acute myeloid leukemia 21 | 783
Epilepsy 20 | 792
Mammary Neoplasms 20 | 425
medulloblastoma 20 | 720
nasopharyngeal carcinoma 20 | 1,058
Cleft Palate 19 | 271
Craniofacial Abnormalities 19 | 151
Muscle hypotonia 19 | 571
Cognitive delay 18 | 608
Cryptorchidism 18 | 296
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
Parkinson's disease 18 | 392
Strabismus 18 | 270
spina bifida 18 | 1,074
Seizures 17 | 596
Liver Cirrhosis, Experimental 16 | 769
Vascular disease 16 | 319
aldosterone-producing adenoma 16 | 665
Alzheimer's disease 15 | 658
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
dermatomyositis 15 | 966
gastric cancer 15 | 459
primary Sjogren syndrome 15 | 735
Atopic dermatitis 14 | 952
Broad flat nasal bridge 14 | 236
Congenital hypoplasia of penis 14 | 176
Deafness 14 | 198
Endometriosis 14 | 540
Lung Neoplasms 14 | 232
Nasal bridge wide 14 | 236
Small head 14 | 374
chronic lymphosyte leukemia 14 | 204
esophageal adenocarcinoma 14 | 737
gastric carcinoma 14 | 807
nephrosclerosis 14 | 333
Uranostaphyloschisis 13 | 167

Tissue

Endocrine System 266 | 18,159
Skin and soft tissues 256 | 17,230
Digestive Tract 251 | 17,369
Female tissues 246 | 17,400
Nervous System 241 | 16,725
Male tissues 240 | 17,142
Blood and immune system 239 | 16,909
Urinary Tract 233 | 16,678
Liver and Pancreas 231 | 16,750
Respiratory system 226 | 16,393
Cardiovascular System 206 | 15,192

Target Family

Transcription Factor 232 | 1,400
Nuclear Receptor 19 | 48
Non-IDG 16 | 12,091
Enzyme 3 | 4,145
Kinase 2 | 634
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

GO Function

transcriptional activator acti... 274 | 274
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 17 ZBTB17 Tbio Transcription Factor -1.57508 40.4 92
CCAAT/enhancer-binding protein epsilon CEBPE Tbio Transcription Factor -1.71776 57.4 246
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
Glucocorticoid modulatory element-binding protein 1 GMEB1 Tbio Transcription Factor -0.75841 7.65 104
Protein fosB FOSB Tbio Transcription Factor -2.66286 432.2 328
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Transcription factor AP-4 TFAP4 Tbio Transcription Factor -1.33384 19.4 276
CCAAT/enhancer-binding protein gamma CEBPG Tbio Transcription Factor -0.92558 8.45 248
Zinc finger and SCAN domain-containing protein 21 ZSCAN21 Tbio Transcription Factor -0.66626 5.08 291