Development Level

Tbio 198 | 10,625
Tchem 23 | 1,890
Tclin 6 | 602
Tdark 3 | 7,003

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to t... 6 | 187
abnormal embryo size 5 | 112
preweaning lethality, incomple... 5 | 260
abnormal forebrain development 4 | 18
abnormal hindbrain development 4 | 24
abnormal neural tube closure 4 | 37
abnormal midbrain development 3 | 22
abnormal sleep behavior 3 | 63
enlarged heart 3 | 111
prenatal lethality prior to he... 3 | 64
abnormal behavior 2 | 226
abnormal heart morphology 2 | 51
abnormal optic disc morphology 2 | 10
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
anophthalmia 2 | 20
decreased body length 2 | 108
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
embryonic growth retardation 2 | 28
increased circulating alkaline... 2 | 119
increased grip strength 2 | 83
abnormal allantois morphology 1 | 3
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal chorioallantoic fusio... 1 | 2
abnormal craniofacial morpholo... 1 | 12
abnormal embryo development 1 | 2
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eyelid aperture 1 | 3
abnormal forebrain morphology 1 | 4
abnormal heart looping 1 | 2
abnormal lens morphology 1 | 73
abnormal neural tube morpholog... 1 | 8
abnormal optic vesicle formati... 1 | 1
abnormal ovary morphology 1 | 3
abnormal pericardium morpholog... 1 | 11
abnormal pharyngeal arch morph... 1 | 2
abnormal seminal vesicle morph... 1 | 47
abnormal social/conspecific in... 1 | 3
abnormal somite shape 1 | 1
abnormal spinal cord morpholog... 1 | 8
abnormal tail bud morphology 1 | 6
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 2
absent epididymis 1 | 2
absent seminal vesicle 1 | 2
corneal opacity 1 | 25
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating serum al... 1 | 79
decreased exploration in new e... 1 | 9
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased macrophage cell numb... 1 | 4
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
female infertility 1 | 34
hemorrhage 1 | 12
hypoactivity 1 | 89
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased coping response 1 | 3
increased exploration in new e... 1 | 56
increased heart rate 1 | 17
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
male infertility 1 | 62
microphthalmia 1 | 15
pale yolk sac 1 | 12
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
prolonged PQ interval 1 | 3
prolonged ST segment 1 | 4
short tibia 1 | 82
shortened ST segment 1 | 9
small testis 1 | 37
thrombocytopenia 1 | 46

Disease

ovarian cancer 120 | 8,484
osteosarcoma 107 | 7,933
psoriasis 106 | 6,685
Cancer 95 | 2,346
medulloblastoma, large-cell 94 | 6,234
lung cancer 77 | 4,466
glioblastoma 74 | 5,572
Breast cancer 60 | 3,094
malignant mesothelioma 59 | 3,162
atypical teratoid / rhabdoid tumor 56 | 4,369
non-small cell lung cancer 56 | 2,798
group 4 medulloblastoma 55 | 1,875
invasive ductal carcinoma 53 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 51 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 48 | 2,988
primitive neuroectodermal tumor 47 | 3,031
interstitial cystitis 45 | 2,299
pancreatic cancer 45 | 2,300
ductal carcinoma in situ 44 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,956
pediatric high grade glioma 44 | 2,712
lung adenocarcinoma 41 | 2,713
pituitary cancer 41 | 1,972
oligodendroglioma 40 | 2,849
ependymoma 37 | 2,514
ulcerative colitis 37 | 2,087
breast carcinoma 36 | 1,614
lung carcinoma 36 | 2,844
sonic hedgehog group medulloblastoma 33 | 1,482
astrocytoma 32 | 1,493
subependymal giant cell astrocytoma 32 | 2,287
pilocytic astrocytoma 30 | 3,086
Rheumatoid Arthritis 29 | 1,160
cystic fibrosis 27 | 1,665
adult high grade glioma 26 | 2,148
adrenocortical carcinoma 25 | 1,427
astrocytic glioma 25 | 2,241
diabetes mellitus 24 | 1,663
Carcinoma 23 | 2,147
colon cancer 23 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
cutaneous lupus erythematosus 22 | 1,056
posterior fossa group A ependymoma 22 | 1,511
primary pancreatic ductal adenocarcinoma 21 | 1,271
Multiple myeloma 20 | 1,327
acute quadriplegic myopathy 20 | 1,157
Mammary Neoplasms 19 | 410
acute myeloid leukemia 19 | 780
juvenile dermatomyositis 19 | 1,189
tuberculosis 19 | 1,557
Obesity 18 | 616
atypical teratoid/rhabdoid tumor 18 | 1,095
group 3 medulloblastoma 18 | 2,254
medulloblastoma 18 | 1,524
nasopharyngeal carcinoma 18 | 1,056
Craniofacial Abnormalities 17 | 147
Pick disease 17 | 1,893
non primary Sjogren syndrome sicca 16 | 840
posterior fossa group B ependymoma 16 | 1,530
primary Sjogren syndrome 16 | 789
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
spina bifida 15 | 1,064
Atopic dermatitis 14 | 944
Parkinson's disease 14 | 364
Prostatic Neoplasms 14 | 471
dermatomyositis 14 | 933
chronic lymphosyte leukemia 13 | 232
fibroadenoma 13 | 557
gastric carcinoma 13 | 832
nephrosclerosis 13 | 329
Endometriosis 12 | 535
active Crohn's disease 12 | 918
aldosterone-producing adenoma 12 | 664
esophageal adenocarcinoma 12 | 737
inflammatory breast cancer 12 | 404
Duchenne muscular dystrophy 11 | 602
Heart disease 11 | 279
Liver carcinoma 11 | 217
Vascular disease 11 | 281
gastric cancer 11 | 430
Alzheimer's disease 10 | 644
Amyotrophic Lateral Sclerosis 10 | 431
Juvenile arthritis 10 | 124
Kidney disease 10 | 396
glioblastoma multiforme 10 | 347
hepatocellular carcinoma 10 | 532
pancreatic carcinoma 10 | 567
Adenoma 9 | 165
Bipolar Disorder 9 | 266
Cleft palate 9 | 125
Down syndrome 9 | 548
Intellectual disability 9 | 573
Leukemia, Myelocytic, Acute 9 | 113
Lung Neoplasms 9 | 171
Neoplastic Cell Transformation 9 | 81
Waldenstrons macroglobulinemia 9 | 765
urothelial carcinoma 9 | 318
Leukemia 8 | 88
Prostate cancer 8 | 172
Schizophrenia 8 | 501

Tissue

Digestive Tract 230 | 18,473
Endocrine System 230 | 18,512
Female tissues 230 | 18,647
Nervous System 230 | 18,561
Urinary Tract 228 | 18,444
Skin and soft tissues 227 | 18,115
Cardiovascular System 226 | 17,958
Male tissues 225 | 17,969
Liver and Pancreas 223 | 18,136
Blood and immune system 219 | 17,995
Respiratory system 212 | 17,484

Target Family

Transcription Factor 200 | 1,400
Nuclear Receptor 15 | 48
Non-IDG 10 | 11,971
Enzyme 3 | 4,146
Kinase 2 | 634

GO Function

transcriptional activator acti... 230 | 230
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Pancreas transcription factor 1 subunit alpha PTF1A Tbio Transcription Factor -2.56282 377.5 283
Zinc finger protein GLIS2 GLIS2 Tbio Transcription Factor -1.86726 74.7 85
BarH-like 1 homeobox protein BARHL1 Tbio Transcription Factor -1.06351 11.8 78
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Erythroid transcription factor GATA1 Tbio Transcription Factor -2.97791 941.1 675
Krueppel-like factor 5 KLF5 Tchem Transcription Factor -2.15588 189.7 186
Forkhead box protein L2 FOXL2 Tbio Transcription Factor -2.76212 610.7 220
Transcriptional activator GLI3 GLI3 Tbio Transcription Factor -3.17963 1388.1 188