Development Level

Tbio 142 | 10,625
Tchem 33 | 1,890
Tdark 21 | 7,003
Tclin 6 | 602

IMPC Phenotype

preweaning lethality, complete... 9 | 633
abnormal behavior 5 | 226
decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
embryonic lethality prior to t... 5 | 187
increased bone mineral content 4 | 92
increased circulating alkaline... 4 | 119
increased lean body mass 4 | 107
preweaning lethality, incomple... 4 | 260
abnormal bone structure 3 | 131
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 85
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
enlarged heart 3 | 111
increased mean corpuscular vol... 3 | 91
abnormal bone mineralization 2 | 55
abnormal eye morphology 2 | 38
abnormal eye posterior chamber... 2 | 3
abnormal head morphology 2 | 10
decreased T cell number 2 | 31
decreased body length 2 | 108
decreased body weight 2 | 174
decreased caudal vertebrae num... 2 | 49
decreased circulating alkaline... 2 | 41
decreased circulating glucose ... 2 | 121
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 19
decreased prepulse inhibition 2 | 52
hyperactivity 2 | 108
increased mean corpuscular hem... 2 | 93
increased or absent threshold ... 2 | 128
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
straub tail 2 | 26
thin ventricular wall 2 | 5
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal coat- hair morphology 1 | 18
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
convulsive seizures 1 | 11
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased IgG1 level 1 | 4
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased mean corpuscular vol... 1 | 50
decreased mean platelet volume 1 | 12
decreased spleen weight 1 | 13
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased NK cell number 1 | 19
increased blood uric acid leve... 1 | 5
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased cardiac muscle contr... 1 | 5
increased circulating HDL chol... 1 | 63
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased leukocyte cell numbe... 1 | 37
increased marginal zone B cell... 1 | 3
increased startle reflex 1 | 38
increased vertical activity 1 | 18
limb grasping 1 | 35
oligodactyly 1 | 14
small kidney 1 | 10
small spleen 1 | 11
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 114 | 7,933
ovarian cancer 105 | 8,491
psoriasis 89 | 6,685
Cancer 85 | 2,346
lung cancer 71 | 4,473
medulloblastoma, large-cell 71 | 6,234
glioblastoma 66 | 5,572
atypical teratoid / rhabdoid tumor 55 | 4,369
Breast cancer 51 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,289
malignant mesothelioma 47 | 3,163
primitive neuroectodermal tumor 45 | 3,031
invasive ductal carcinoma 43 | 2,950
Carcinoma 41 | 2,147
non-small cell lung cancer 39 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,956
ependymoma 36 | 2,514
interstitial cystitis 36 | 2,299
pediatric high grade glioma 35 | 2,712
lung carcinoma 34 | 2,844
ductal carcinoma in situ 33 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,988
lung adenocarcinoma 33 | 2,714
pancreatic cancer 33 | 2,300
pilocytic astrocytoma 32 | 3,086
ulcerative colitis 31 | 2,087
breast carcinoma 29 | 1,614
group 4 medulloblastoma 29 | 1,875
group 3 medulloblastoma 28 | 2,254
oligodendroglioma 28 | 2,849
subependymal giant cell astrocytoma 28 | 2,287
pituitary cancer 27 | 1,972
Rheumatoid Arthritis 26 | 1,170
Pick disease 25 | 1,893
diabetes mellitus 25 | 1,663
astrocytic glioma 23 | 2,241
astrocytoma 23 | 1,493
tuberculosis 23 | 1,563
Multiple myeloma 22 | 1,327
acute quadriplegic myopathy 22 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
primary pancreatic ductal adenocarcinoma 21 | 1,271
Mammary Neoplasms 20 | 410
adult high grade glioma 20 | 2,148
medulloblastoma 20 | 1,524
cystic fibrosis 19 | 1,670
sonic hedgehog group medulloblastoma 19 | 1,482
acute myeloid leukemia 18 | 785
colon cancer 18 | 1,475
Waldenstrons macroglobulinemia 16 | 764
Prostatic Neoplasms 15 | 471
aldosterone-producing adenoma 15 | 664
juvenile dermatomyositis 15 | 1,189
posterior fossa group A ependymoma 15 | 1,511
cutaneous lupus erythematosus 14 | 1,056
posterior fossa group B ependymoma 14 | 1,530
Craniofacial Abnormalities 13 | 147
Intellectual disability 13 | 573
Kidney disease 13 | 397
Obesity 13 | 616
dermatomyositis 13 | 966
fibroadenoma 13 | 557
gastric carcinoma 13 | 832
Alzheimer's disease 12 | 644
Colorectal Neoplasms 12 | 217
adrenocortical carcinoma 12 | 1,427
Colonic Neoplasms 11 | 126
Diabetes Mellitus, Non-Insulin-Dependent 11 | 161
Endometriosis 11 | 535
Liver carcinoma 11 | 217
Pancreatic Neoplasm 11 | 79
Parkinson's disease 11 | 364
nasopharyngeal carcinoma 11 | 1,056
Adenocarcinoma 10 | 115
Amyotrophic Lateral Sclerosis 10 | 432
Asthma 10 | 349
Atopic dermatitis 10 | 944
Crohn's disease 10 | 304
Lung Neoplasms 10 | 171
Peripheral Neuropathy 10 | 303
Schizophrenia 10 | 503
Stomach Neoplasms 10 | 282
Vascular disease 10 | 281
atypical teratoid/rhabdoid tumor 10 | 1,095
esophageal adenocarcinoma 10 | 737
pancreatic carcinoma 10 | 567
primary Sjogren syndrome 10 | 788
Adenoma 9 | 165
Congenital heart disease 9 | 63
Liver neoplasms 9 | 108
Polycystic Ovary Syndrome 9 | 334
active ulcerative colitis 9 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
inflammatory breast cancer 9 | 404
spina bifida 9 | 1,064
Inflammatory bowel disease 8 | 142
Multiple Sclerosis 8 | 498
Prostate cancer 8 | 172
hepatocellular carcinoma 8 | 550
tuberculosis and treatment for 6 months 8 | 686

Tissue

Blood and immune system 202 | 17,994
Cardiovascular System 202 | 17,957
Digestive Tract 202 | 18,472
Endocrine System 202 | 18,511
Female tissues 202 | 18,646
Male tissues 202 | 17,968
Nervous System 202 | 18,560
Liver and Pancreas 201 | 18,135
Skin and soft tissues 201 | 18,114
Urinary Tract 201 | 18,443
Respiratory system 200 | 17,483

Target Family

Transcription Factor 135 | 1,400
Non-IDG 44 | 11,969
Epigenetic 9 | 242
Nuclear Receptor 7 | 48
TF/Epigenetic 4 | 38
Enzyme 2 | 4,146
Kinase 1 | 634

GO Function

transcription regulatory regio... 202 | 202
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.66256 471.8 306
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.58936 5.14 132
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.04240 90.2 423
X-ray repair cross-complementing protein 5 XRCC5 Tbio Non-IDG -2.67147 456.7 712
Sal-like protein 3 SALL3 Tbio Transcription Factor -0.90858 9.10 15
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.75815 5706.6 1539
POU domain, class 5, transcription factor 1 POU5F1 Tbio Transcription Factor -3.28009 1980.8 817