Development Level

Tbio 155 | 11,445
Tchem 30 | 1,598
Tdark 14 | 6,588
Tclin 6 | 613

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 19 | 979
decreased vertical activity 8 | 208
enlarged heart 8 | 210
abnormal behavior 7 | 298
decreased total body fat amoun... 7 | 207
embryonic lethality prior to t... 6 | 278
increased lean body mass 6 | 172
abnormal heart morphology 5 | 162
abnormal kidney morphology 5 | 65
preweaning lethality, incomple... 5 | 499
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
decreased circulating glucose ... 4 | 126
decreased prepulse inhibition 4 | 82
increased bone mineral content 4 | 108
increased circulating HDL chol... 4 | 80
abnormal retinal blood vessel ... 3 | 26
cataract 3 | 92
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
hypoactivity 3 | 132
increased mean corpuscular hem... 3 | 96
increased startle reflex 3 | 112
thrombocytopenia 3 | 56
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal cranium morphology 2 | 36
abnormal eye morphology 2 | 68
abnormal facial morphology 2 | 17
abnormal head morphology 2 | 10
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased IgG1 level 2 | 8
decreased T cell number 2 | 15
decreased blood urea nitrogen ... 2 | 51
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased red blood cell distr... 2 | 41
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased grip strength 2 | 41
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
increased vertical activity 2 | 24
prenatal lethality prior to he... 2 | 87
thin ventricular wall 2 | 24
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal ear morphology 1 | 9
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal neural tube closure 1 | 46
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
increased anti-nuclear antigen... 1 | 19
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased body weight 1 | 25
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
shortened RR interval 1 | 17
small kidney 1 | 16
small spleen 1 | 19
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 157 | 11,493
osteosarcoma 117 | 7,950
ovarian cancer 105 | 8,520
Cancer 93 | 2,499
psoriasis 89 | 6,694
lung cancer 74 | 4,740
medulloblastoma, large-cell 73 | 6,241
glioblastoma 71 | 5,792
atypical teratoid / rhabdoid tumor 63 | 5,112
Breast cancer 60 | 3,578
ependymoma 54 | 4,679
group 3 medulloblastoma 51 | 4,104
malignant mesothelioma 51 | 3,232
primitive neuroectodermal tumor 47 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 46 | 3,291
Kidney cancer 43 | 2,613
invasive ductal carcinoma 42 | 2,951
adult high grade glioma 40 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,955
non-small cell lung cancer 40 | 2,890
interstitial cystitis 37 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,989
lung carcinoma 35 | 2,843
pancreatic cancer 33 | 2,398
astrocytic glioma 32 | 2,597
breast carcinoma 32 | 1,638
ductal carcinoma in situ 32 | 1,745
lung adenocarcinoma 32 | 2,716
tuberculosis 31 | 2,010
ulcerative colitis 31 | 1,819
Astrocytoma, Pilocytic 29 | 3,081
diabetes mellitus 29 | 1,728
Intellectual disability 28 | 1,016
group 4 medulloblastoma 28 | 1,855
oligodendroglioma 28 | 2,850
Rheumatoid arthritis 27 | 1,191
subependymal giant cell astrocytoma 27 | 2,287
Pick disease 26 | 1,894
Schizophrenia 25 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
pituitary cancer 25 | 1,972
Breast Neoplasms 23 | 445
Multiple myeloma 22 | 1,332
acute quadriplegic myopathy 22 | 1,158
Mammary Neoplasms 20 | 425
acute myeloid leukemia 19 | 783
cystic fibrosis 19 | 1,696
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
colon cancer 18 | 1,478
Autosomal recessive predisposition 17 | 1,442
Epilepsy 17 | 792
Obesity 17 | 678
Prostatic Neoplasms 17 | 495
Seizures 17 | 596
primary pancreatic ductal adenocarcinoma 17 | 1,109
Alzheimer's disease 16 | 658
Liver cancer 16 | 604
Short stature 16 | 531
Waldenstrons macroglobulinemia 16 | 765
juvenile dermatomyositis 16 | 1,187
pediatric high grade glioma 16 | 1,064
Cryptorchidism 15 | 296
aldosterone-producing adenoma 15 | 665
Kidney disease 14 | 430
astrocytoma 14 | 1,146
cutaneous lupus erythematosus 14 | 1,057
Carcinoma, Hepatocellular 13 | 228
Colonic Neoplasms 13 | 142
Craniofacial Abnormalities 13 | 151
Liver carcinoma 13 | 240
Muscle hypotonia 13 | 571
Polycystic ovary syndrome 13 | 360
dermatomyositis 13 | 966
fibroadenoma 13 | 559
gastric carcinoma 13 | 807
Cognitive delay 12 | 608
Colorectal Neoplasms 12 | 243
Depressive disorder 12 | 409
Endometriosis 12 | 540
Global developmental delay 12 | 608
Hypertensive disease 12 | 292
Lung Neoplasms 12 | 232
Mental and motor retardation 12 | 608
Pancreatic Neoplasm 12 | 85
Pancreatic Neoplasms 12 | 85
Parkinson's disease 12 | 392
Sensorineural Hearing Loss (disorder) 12 | 284
Small head 12 | 374
adrenocortical carcinoma 12 | 1,428
Bipolar Disorder 11 | 666
Diabetes Mellitus, Non-Insulin-Dependent 11 | 145
Orbital separation excessive 11 | 244
Osteoporosis 11 | 363
Stomach Neoplasms 11 | 300
active ulcerative colitis 11 | 764
sonic hedgehog group medulloblastoma 11 | 467

Tissue

Endocrine System 201 | 18,159
Female tissues 201 | 17,400
Digestive Tract 200 | 17,369
Male tissues 200 | 17,142
Urinary Tract 198 | 16,678
Liver and Pancreas 196 | 16,750
Skin and soft tissues 196 | 17,230
Blood and immune system 195 | 16,909
Respiratory system 195 | 16,393
Nervous System 194 | 16,725
Cardiovascular System 179 | 15,192

Target Family

Transcription Factor 137 | 1,400
Non-IDG 41 | 12,091
Epigenetic 9 | 242
Nuclear Receptor 7 | 48
TF/Epigenetic 5 | 38
Kinase 4 | 634
Enzyme 2 | 4,145

GO Function

transcription regulatory regio... 205 | 205
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Metastasis-associated protein MTA2 MTA2 Tbio Transcription Factor -1.59201 32.3 283
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
Zinc finger protein Helios IKZF2 Tbio Transcription Factor -1.26324 15.8 221
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
Sal-like protein 4 SALL4 Tbio Transcription Factor -2.64737 454.3 165
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.68609 492.0 349
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.69436 6.18 146
Transcription factor SOX-7 SOX7 Tbio Transcription Factor -1.69107 35.6 169
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514