Development Level

Tbio 213 | 11,445
Tchem 57 | 1,598
Tclin 17 | 613
Tdark 10 | 6,588

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 27 | 979
preweaning lethality, incomple... 11 | 499
abnormal behavior 8 | 298
embryonic lethality prior to t... 7 | 278
abnormal heart morphology 6 | 162
enlarged heart 6 | 210
decreased total body fat amoun... 5 | 207
abnormal embryo size 4 | 220
abnormal skin morphology 4 | 50
decreased bone mineral density 4 | 126
increased or absent threshold ... 4 | 101
increased startle reflex 4 | 112
short tibia 4 | 97
abnormal bone structure 3 | 187
abnormal eye morphology 3 | 68
abnormal retina morphology 3 | 71
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased circulating LDL chol... 3 | 38
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
abnormal coat- hair morphology 2 | 19
abnormal cornea morphology 2 | 31
abnormal forebrain development 2 | 20
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal motor capabilities-co... 2 | 5
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
hyperactivity 2 | 148
hypoactivity 2 | 132
increased body length 2 | 32
increased circulating potassiu... 2 | 29
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
male infertility 2 | 123
pale yolk sac 2 | 25
pallor 2 | 34
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal liver morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
corneal opacity 1 | 32
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged uterus 1 | 11
impaired glucose tolerance 1 | 75
increased blood uric acid leve... 1 | 5
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
microphthalmia 1 | 26
prenatal lethality 1 | 28
small kidney 1 | 16
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 202 | 11,493
ovarian cancer 175 | 8,520
osteosarcoma 161 | 7,950
Cancer 143 | 2,499
medulloblastoma, large-cell 135 | 6,241
psoriasis 131 | 6,694
lung cancer 125 | 4,740
glioblastoma 122 | 5,792
atypical teratoid / rhabdoid tumor 100 | 5,112
Breast cancer 93 | 3,578
malignant mesothelioma 91 | 3,232
ependymoma 88 | 4,679
group 3 medulloblastoma 79 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 71 | 3,291
primitive neuroectodermal tumor 70 | 3,035
adult high grade glioma 66 | 3,801
oligodendroglioma 66 | 2,850
non-small cell lung cancer 62 | 2,890
invasive ductal carcinoma 60 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 59 | 2,989
lung adenocarcinoma 58 | 2,716
Astrocytoma, Pilocytic 57 | 3,081
pancreatic cancer 55 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,955
Kidney cancer 53 | 2,613
diabetes mellitus 53 | 1,728
pituitary cancer 52 | 1,972
astrocytic glioma 51 | 2,597
Multiple myeloma 49 | 1,332
subependymal giant cell astrocytoma 49 | 2,287
lung carcinoma 47 | 2,843
interstitial cystitis 43 | 2,312
breast carcinoma 42 | 1,638
group 4 medulloblastoma 42 | 1,855
tuberculosis 42 | 2,010
Rheumatoid arthritis 41 | 1,191
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,962
astrocytoma 38 | 1,146
colon cancer 38 | 1,478
ductal carcinoma in situ 38 | 1,745
ulcerative colitis 38 | 1,819
Breast Neoplasms 37 | 445
Pick disease 37 | 1,894
Intellectual disability 36 | 1,016
Mammary Neoplasms 35 | 425
Schizophrenia 35 | 1,160
cystic fibrosis 35 | 1,696
adrenocortical carcinoma 34 | 1,428
primary pancreatic ductal adenocarcinoma 30 | 1,109
Obesity 28 | 678
Waldenstrons macroglobulinemia 27 | 765
acute myeloid leukemia 27 | 783
Dull intelligence 26 | 645
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Poor school performance 26 | 645
Prostatic Neoplasms 26 | 495
dermatomyositis 26 | 966
Epilepsy 25 | 792
Short stature 25 | 531
Autosomal recessive predisposition 24 | 1,442
acute quadriplegic myopathy 24 | 1,158
juvenile dermatomyositis 24 | 1,187
Seizures 23 | 596
Carcinoma, Hepatocellular 22 | 228
Liver carcinoma 22 | 240
Small head 22 | 374
Vascular disease 22 | 319
gastric carcinoma 22 | 807
Alzheimer's disease 21 | 658
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Lung Neoplasms 20 | 232
Mental and motor retardation 20 | 608
Parkinson's disease 20 | 392
pediatric high grade glioma 20 | 1,064
Bipolar Disorder 19 | 666
Cleft Palate 19 | 271
Cryptorchidism 19 | 296
Kidney disease 19 | 430
aldosterone-producing adenoma 19 | 665
spina bifida 19 | 1,074
Amyotrophic lateral sclerosis 18 | 451
Heart disease 18 | 306
Melanoma 18 | 711
Muscle hypotonia 18 | 571
Strabismus 18 | 270
active ulcerative colitis 18 | 764
Acquired metabolic disease 17 | 336
Atopic dermatitis 17 | 952
Colonic Neoplasms 17 | 142
Endometriosis 17 | 540
Hypertension 17 | 396
Hypertensive disease 17 | 292
cutaneous lupus erythematosus 17 | 1,057
sonic hedgehog group medulloblastoma 17 | 467
Depressive disorder 16 | 409
Immune system cancer 16 | 140
Stomach Neoplasms 16 | 300

Tissue

Endocrine System 294 | 18,159
Digestive Tract 291 | 17,369
Female tissues 291 | 17,400
Male tissues 290 | 17,142
Skin and soft tissues 290 | 17,230
Liver and Pancreas 288 | 16,750
Urinary Tract 288 | 16,678
Blood and immune system 287 | 16,909
Respiratory system 285 | 16,393
Nervous System 282 | 16,725
Cardiovascular System 274 | 15,192

Target Family

Transcription Factor 120 | 1,400
Non-IDG 97 | 12,091
Enzyme 28 | 4,145
Epigenetic 23 | 242
Kinase 14 | 634
Nuclear Receptor 11 | 48
TF/Epigenetic 2 | 38
GPCR 1 | 408
Transporter 1 | 473

GO Function

transcription factor binding 297 | 297
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcriptional activator protein Pur-beta PURB Tbio Non-IDG -1.49692 30.7 79
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Insulin-induced gene 2 protein INSIG2 Tbio Non-IDG -1.94599 88.7 78
Transcription factor MafB MAFB Tbio Transcription Factor -2.01655 101.2 191
Methyltransferase-like protein 23 METTL23 Tdark Enzyme -0.17609 1.92 6
Sal-like protein 4 SALL4 Tbio Transcription Factor -2.64737 454.3 165
Transcription factor HES-2 HES2 Tdark Transcription Factor -0.19957 1.87 213
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.69436 6.18 146
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335