Development Level

Tbio 531 | 10,625
Tdark 247 | 7,003
Tchem 60 | 1,890
Tclin 15 | 602

IMPC Term

preweaning lethality, complete... 23 | 633
preweaning lethality, incomple... 17 | 260
embryonic lethality prior to t... 11 | 187
abnormal behavior 9 | 226
decreased lean body mass 8 | 195
increased lean body mass 8 | 107
decreased grip strength 7 | 123
decreased total body fat amoun... 7 | 186
abnormal bone mineralization 6 | 55
abnormal embryo size 6 | 112
abnormal retina morphology 6 | 100
decreased body weight 6 | 174
increased mean corpuscular vol... 6 | 91
increased or absent threshold ... 6 | 128
decreased bone mineral density 5 | 126
decreased caudal vertebrae num... 5 | 49
decreased erythrocyte cell num... 5 | 43
decreased hemoglobin content 5 | 53
embryonic lethality prior to o... 5 | 148
hypoactivity 5 | 89
increased bone mineral content 5 | 92
increased circulating alkaline... 5 | 119
increased fasted circulating g... 5 | 68
abnormal bone structure 4 | 131
abnormal retinal pigmentation 4 | 61
abnormal startle reflex 4 | 14
decreased bone mineral content 4 | 157
decreased circulating glucose ... 4 | 121
decreased circulating insulin ... 4 | 75
decreased circulating serum al... 4 | 79
decreased mature B cell number 4 | 25
decreased prepulse inhibition 4 | 52
decreased rib number 4 | 59
increased bone mineral density 4 | 52
abnormal cornea morphology 3 | 24
abnormal forebrain development 3 | 18
abnormal hindbrain development 3 | 24
abnormal neural tube closure 3 | 37
abnormal sleep behavior 3 | 63
corneal opacity 3 | 25
decreased B cell number 3 | 30
decreased body length 3 | 108
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased circulating fructosa... 3 | 31
decreased circulating triglyce... 3 | 83
decreased effector memory CD8-... 3 | 24
decreased hematocrit 3 | 25
enlarged heart 3 | 111
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
prenatal lethality prior to he... 3 | 64
short tibia 3 | 82
abnormal behavioral response t... 2 | 52
abnormal head morphology 2 | 10
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal locomotor activation 2 | 26
abnormal midbrain development 2 | 22
abnormal optic disc morphology 2 | 10
abnormal spleen morphology 2 | 36
decreased CD4-positive, CD25-p... 2 | 24
decreased Ly6C low monocyte nu... 2 | 23
decreased T cell number 2 | 31
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating aspartat... 2 | 27
decreased circulating chloride... 2 | 32
decreased circulating glycerol... 2 | 19
decreased circulating iron lev... 2 | 25
decreased circulating sodium l... 2 | 18
decreased circulating total pr... 2 | 41
decreased fasted circulating g... 2 | 49
decreased gamma-delta T cell n... 2 | 18
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 19
hemorrhage 2 | 12
hyperactivity 2 | 108
improved glucose tolerance 2 | 56
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased circulating HDL chol... 2 | 63
increased circulating amylase ... 2 | 13
increased circulating choleste... 2 | 53
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased effector memory CD8-... 2 | 14
increased lactate dehydrogenas... 2 | 3
increased monocyte cell number 2 | 27
increased neutrophil cell numb... 2 | 15
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
small spleen 2 | 11
small testis 2 | 37
thrombocytopenia 2 | 46
tremors 2 | 34
trunk curl 2 | 15
decreased mean corpuscular hem... 1 | 34
increased NK cell number 1 | 19

Disease

osteosarcoma 424 | 7,933
ovarian cancer 403 | 8,484
psoriasis 325 | 6,685
medulloblastoma, large-cell 303 | 6,234
glioblastoma 276 | 5,572
lung cancer 247 | 4,466
atypical teratoid / rhabdoid tumor 209 | 4,369
Cancer 192 | 2,346
malignant mesothelioma 181 | 3,162
Breast cancer 173 | 3,094
primitive neuroectodermal tumor 169 | 3,031
group 4 medulloblastoma 155 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 154 | 3,289
pediatric high grade glioma 139 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 135 | 2,988
oligodendroglioma 135 | 2,849
invasive ductal carcinoma 131 | 2,950
ependymoma 128 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 123 | 2,956
pilocytic astrocytoma 119 | 3,086
lung carcinoma 117 | 2,844
non-small cell lung cancer 112 | 2,798
pancreatic cancer 111 | 2,300
interstitial cystitis 108 | 2,299
Carcinoma 103 | 2,147
pituitary cancer 98 | 1,972
astrocytoma 95 | 1,493
group 3 medulloblastoma 94 | 2,254
lung adenocarcinoma 94 | 2,713
ulcerative colitis 93 | 2,087
subependymal giant cell astrocytoma 92 | 2,287
astrocytic glioma 91 | 2,241
Rheumatoid Arthritis 88 | 1,160
ductal carcinoma in situ 86 | 1,745
breast carcinoma 85 | 1,614
sonic hedgehog group medulloblastoma 83 | 1,482
Pick disease 81 | 1,893
cystic fibrosis 79 | 1,665
tuberculosis 79 | 1,557
adult high grade glioma 77 | 2,148
medulloblastoma 76 | 1,524
primary pancreatic ductal adenocarcinoma 68 | 1,271
colon cancer 66 | 1,475
adrenocortical carcinoma 61 | 1,427
posterior fossa group A ependymoma 61 | 1,511
diabetes mellitus 60 | 1,663
juvenile dermatomyositis 60 | 1,189
spina bifida 60 | 1,064
posterior fossa group B ependymoma 59 | 1,530
pancreatic ductal adenocarcinoma liver metastasis 57 | 1,795
acute quadriplegic myopathy 53 | 1,157
acute myeloid leukemia 50 | 780
atypical teratoid/rhabdoid tumor 49 | 1,095
cutaneous lupus erythematosus 47 | 1,056
Multiple myeloma 46 | 1,327
aldosterone-producing adenoma 44 | 664
dermatomyositis 44 | 933
primary Sjogren syndrome 44 | 789
tuberculosis and treatment for 6 months 43 | 686
gastric carcinoma 41 | 832
Mammary Neoplasms 38 | 410
Atopic dermatitis 37 | 944
hepatocellular carcinoma 37 | 532
Craniofacial Abnormalities 36 | 147
non primary Sjogren syndrome sicca 35 | 840
Alzheimer's disease 34 | 644
Intellectual disability 34 | 573
Obesity 33 | 616
Prostatic Neoplasms 33 | 471
gastric cancer 33 | 430
nasopharyngeal carcinoma 33 | 1,056
Endometriosis 31 | 535
Amyotrophic Lateral Sclerosis 30 | 431
Down syndrome 29 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 499
progressive supranuclear palsy 29 | 674
Waldenstrons macroglobulinemia 28 | 765
active Crohn's disease 28 | 918
Acquired metabolic disease 27 | 267
esophageal adenocarcinoma 27 | 737
pancreatic carcinoma 26 | 567
Liver carcinoma 25 | 217
fibroadenoma 25 | 557
active ulcerative colitis 24 | 477
Cleft palate 23 | 125
chronic rhinosinusitis 23 | 512
Kidney disease 22 | 396
inflammatory breast cancer 22 | 404
Crohn's disease 21 | 304
glioblastoma multiforme 21 | 347
tuberculosis and treatment for 3 months 21 | 327
Multiple Sclerosis 20 | 498
Vascular disease 20 | 281
Lung Neoplasms 19 | 171
Schizophrenia 19 | 501
Chronic Lymphocytic Leukemia 18 | 242
Colonic Neoplasms 18 | 126
Peripheral Neuropathy 18 | 303
chronic lymphosyte leukemia 18 | 232
Diabetes Mellitus, Non-Insulin-Dependent 17 | 157

Tissue

Female tissues 838 | 18,647
Nervous System 837 | 18,561
Digestive Tract 835 | 18,473
Endocrine System 834 | 18,512
Urinary Tract 831 | 18,444
Male tissues 830 | 17,969
Cardiovascular System 828 | 17,958
Blood and immune system 827 | 17,995
Liver and Pancreas 824 | 18,136
Skin and soft tissues 821 | 18,115
Respiratory system 806 | 17,484

Target Family

Transcription Factor 665 | 1,400
Non-IDG 116 | 11,971
Nuclear Receptor 26 | 48
Epigenetic 18 | 242
Enzyme 12 | 4,146
TF/Epigenetic 12 | 38
Transporter 3 | 473
Kinase 1 | 634

GO Function

transcription factor activity,... 853 | 853
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Sex comb on midleg-like protein 2 SCML2 Tbio Epigenetic -1.13986 13.7 93
POU domain, class 3, transcription factor 4 POU3F4 Tbio Transcription Factor -2.24459 179.3 55
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Interferon regulatory factor 9 IRF9 Tbio Transcription Factor -1.79340 61.7 168
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373
Zinc finger protein 155 ZNF155 Tdark Transcription Factor 0.48 0.07 74
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.33707 243.8 508