Development Level

Tbio 542 | 11,445
Tdark 216 | 6,588
Tchem 43 | 1,598
Tclin 15 | 613

IMPC Phenotype

preweaning lethality, complete... 44 | 979
preweaning lethality, incomple... 21 | 499
embryonic lethality prior to t... 14 | 278
increased lean body mass 13 | 172
decreased total body fat amoun... 11 | 207
abnormal behavior 10 | 298
abnormal embryo size 10 | 220
increased total body fat amoun... 9 | 134
decreased lean body mass 8 | 135
abnormal bone structure 7 | 187
decreased body weight 7 | 161
decreased bone mineral density 7 | 126
decreased circulating glucose ... 7 | 126
decreased vertical activity 7 | 208
enlarged heart 7 | 210
abnormal heart morphology 6 | 162
abnormal retina morphology 6 | 71
decreased erythrocyte cell num... 6 | 62
decreased prepulse inhibition 6 | 82
increased bone mineral content 6 | 108
increased bone mineral density 6 | 72
increased circulating alkaline... 6 | 122
increased mean corpuscular hem... 6 | 96
increased mean corpuscular vol... 6 | 92
increased startle reflex 6 | 112
decreased circulating triglyce... 5 | 79
embryonic lethality prior to o... 5 | 239
hypoactivity 5 | 132
increased fasted circulating g... 5 | 76
abnormal bone mineralization 4 | 38
abnormal gait 4 | 69
abnormal startle reflex 4 | 15
decreased bone mineral content 4 | 151
decreased circulating serum al... 4 | 82
decreased hemoglobin content 4 | 68
embryonic growth retardation 4 | 106
improved glucose tolerance 4 | 79
increased neutrophil cell numb... 4 | 46
male infertility 4 | 123
thrombocytopenia 4 | 56
abnormal behavioral response t... 3 | 66
abnormal cornea morphology 3 | 31
abnormal kidney morphology 3 | 65
abnormal neural tube closure 3 | 46
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
corneal opacity 3 | 32
decreased blood urea nitrogen ... 3 | 51
decreased caudal vertebrae num... 3 | 53
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased hematocrit 3 | 46
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
hemorrhage 3 | 23
increased circulating HDL chol... 3 | 80
increased circulating amylase ... 3 | 25
increased circulating triglyce... 3 | 42
increased grip strength 3 | 41
increased or absent threshold ... 3 | 101
microphthalmia 3 | 26
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
small testis 3 | 58
abnormal craniofacial morpholo... 2 | 33
abnormal head morphology 2 | 10
abnormal locomotor activation 2 | 16
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
abnormal tooth morphology 2 | 24
abnormal vertebrae morphology 2 | 18
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
decreased IgG1 level 2 | 8
decreased T cell number 2 | 15
decreased body length 2 | 101
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating iron lev... 2 | 32
decreased circulating sodium l... 2 | 22
decreased neutrophil cell numb... 2 | 42
decreased startle reflex 2 | 75
enlarged spleen 2 | 41
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased anti-nuclear antigen... 2 | 19
increased blood urea nitrogen ... 2 | 48
increased circulating aspartat... 2 | 15
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
limb grasping 2 | 41
thin ventricular wall 2 | 24
tremors 2 | 39

Disease

Carcinoma 567 | 11,493
osteosarcoma 406 | 7,950
ovarian cancer 381 | 8,520
psoriasis 308 | 6,694
medulloblastoma, large-cell 281 | 6,241
glioblastoma 270 | 5,792
lung cancer 247 | 4,740
atypical teratoid / rhabdoid tumor 223 | 5,112
group 3 medulloblastoma 209 | 4,104
Cancer 203 | 2,499
ependymoma 200 | 4,679
Breast cancer 195 | 3,578
malignant mesothelioma 173 | 3,232
primitive neuroectodermal tumor 161 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 147 | 3,291
adult high grade glioma 144 | 3,801
oligodendroglioma 131 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 130 | 2,989
invasive ductal carcinoma 129 | 2,951
Kidney cancer 122 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 117 | 2,955
Astrocytoma, Pilocytic 115 | 3,081
group 4 medulloblastoma 114 | 1,855
lung carcinoma 112 | 2,843
non-small cell lung cancer 110 | 2,890
pancreatic cancer 110 | 2,398
astrocytic glioma 108 | 2,597
interstitial cystitis 104 | 2,312
tuberculosis 97 | 2,010
pituitary cancer 93 | 1,972
lung adenocarcinoma 91 | 2,716
subependymal giant cell astrocytoma 88 | 2,287
breast carcinoma 87 | 1,638
ductal carcinoma in situ 86 | 1,745
ulcerative colitis 83 | 1,819
Rheumatoid arthritis 79 | 1,191
Pick disease 76 | 1,894
cystic fibrosis 76 | 1,696
astrocytoma 71 | 1,146
diabetes mellitus 66 | 1,728
colon cancer 64 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 62 | 1,962
pediatric high grade glioma 62 | 1,064
juvenile dermatomyositis 60 | 1,187
primary pancreatic ductal adenocarcinoma 58 | 1,109
spina bifida 58 | 1,074
Intellectual disability 57 | 1,016
adrenocortical carcinoma 57 | 1,428
Schizophrenia 55 | 1,160
acute quadriplegic myopathy 51 | 1,158
acute myeloid leukemia 48 | 783
Dull intelligence 45 | 645
Low intelligence 45 | 645
Mental Retardation 45 | 645
Mental deficiency 45 | 645
Multiple myeloma 45 | 1,332
Poor school performance 45 | 645
aldosterone-producing adenoma 44 | 665
cutaneous lupus erythematosus 44 | 1,057
medulloblastoma 44 | 720
Short stature 43 | 531
primary Sjogren syndrome 43 | 735
Obesity 42 | 678
dermatomyositis 42 | 966
Breast Neoplasms 40 | 445
Muscle hypotonia 40 | 571
gastric carcinoma 39 | 807
Mammary Neoplasms 38 | 425
Alzheimer's disease 37 | 658
hepatocellular carcinoma 37 | 547
Atopic dermatitis 36 | 952
Autosomal recessive predisposition 36 | 1,442
Cleft Palate 36 | 271
Craniofacial Abnormalities 36 | 151
Bipolar Disorder 35 | 666
gastric cancer 35 | 459
non primary Sjogren syndrome sicca 35 | 891
Prostatic Neoplasms 34 | 495
active ulcerative colitis 34 | 764
nasopharyngeal carcinoma 34 | 1,058
Acquired metabolic disease 32 | 336
Endometriosis 32 | 540
Cognitive delay 31 | 608
Global developmental delay 31 | 608
Mental and motor retardation 31 | 608
Epilepsy 30 | 792
Strabismus 29 | 270
active Crohn's disease 29 | 922
Waldenstrons macroglobulinemia 28 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 510
esophageal adenocarcinoma 28 | 737
progressive supranuclear palsy 28 | 676
tuberculosis and treatment for 6 months 28 | 409
Cryptorchidism 27 | 296
Down syndrome 27 | 499
Small head 27 | 374
Amyotrophic lateral sclerosis 26 | 451
Carcinoma, Hepatocellular 26 | 228
Orbital separation excessive 26 | 244
Seizures 26 | 596

Tissue

Endocrine System 789 | 18,159
Skin and soft tissues 771 | 17,230
Digestive Tract 769 | 17,369
Female tissues 761 | 17,400
Male tissues 759 | 17,142
Blood and immune system 743 | 16,909
Nervous System 743 | 16,725
Urinary Tract 742 | 16,678
Liver and Pancreas 734 | 16,750
Respiratory system 730 | 16,393
Cardiovascular System 685 | 15,192

Target Family

Transcription Factor 629 | 1,400
Non-IDG 115 | 12,091
Nuclear Receptor 27 | 48
Epigenetic 18 | 242
Enzyme 12 | 4,145
TF/Epigenetic 11 | 38
Transporter 3 | 473
Kinase 1 | 634

GO Function

transcription factor activity,... 816 | 816
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
Zinc finger protein Helios IKZF2 Tbio Transcription Factor -1.26324 15.8 221
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Transcription factor SOX-21 SOX21 Tbio Transcription Factor -1.47198 29.1 106
Krueppel-like factor 2 KLF2 Tbio Transcription Factor -2.30630 216.2 308
Zinc finger protein 284 ZNF284 Tdark Transcription Factor 0.90 0.42 63
Zinc finger protein 780B ZNF780B Tdark Transcription Factor 0.40 0.23 82
Zinc finger protein 606 ZNF606 Tdark Transcription Factor -0.09691 1.66 101
Transcription factor-like 5 protein TCFL5 Tbio Transcription Factor -2.62447 404.7 161
Eomesodermin homolog EOMES Tbio Transcription Factor -2.37902 230.4 333