Development Level

Tbio 7 | 11,445
Tchem 3 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

enlarged heart 2 | 210
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
decreased cardiac output 1 | 3
decreased circulating alkaline... 1 | 46
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
increased bone mineral content 1 | 108
increased or absent threshold ... 1 | 101
thin ventricular wall 1 | 24

Disease

medulloblastoma, large-cell 5 | 6,241
osteosarcoma 5 | 7,950
primitive neuroectodermal tumor 5 | 3,035
psoriasis 5 | 6,694
Carcinoma 4 | 11,493
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
ovarian cancer 4 | 8,520
Breast cancer 3 | 3,578
Cancer 3 | 2,499
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
Atopic dermatitis 2 | 952
Bipolar Disorder 2 | 666
Depressive disorder 2 | 409
Seasonal affective disorder 2 | 28
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
Acquired metabolic disease 1 | 336
Acquired scoliosis 1 | 281
Alobar Holoprosencephaly 1 | 14
Alzheimer's disease 1 | 658
Amyotrophic lateral sclerosis 1 | 451
Autistic Disorder 1 | 364
Cerebral palsy 1 | 40
Chromosome 17q11.2 deletion syndrome, 1.4Mb 1 | 15
Constipation 1 | 181
Curvature of spine 1 | 282
Cyclocephaly 1 | 4
Decreased projection of maxilla 1 | 66
Decreased projection of midface 1 | 105
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Deficiency of upper jaw bones 1 | 66
Dyschezia 1 | 135
Electroencephalogram abnormal 1 | 101
Endocarditis 1 | 19
Enhanced S-cone syndrome 1 | 17
Epilepsy 1 | 792
Fatty Liver 1 | 70
HIV Infections 1 | 102
Hemiparesis 1 | 34
Hereditary spastic paraplegia 23 1 | 2
Highly variable severity 1 | 157
Holoprosencephaly 1 | 56
Hypodontia 1 | 81
Hypoplasia of the maxilla 1 | 66
Hypoplasia or absence of the corpus callosum 1 | 23
Hypotrophic malar bone 1 | 129
Hypotrophic maxilla 1 | 66
Hypotrophic midface 1 | 105
Isolated cases 1 | 72
Lissencephaly 1 | 69
Liver Cirrhosis, Experimental 1 | 769
Liver neoplasms 1 | 130
Malar flattening 1 | 129
Maxillary retrognathia 1 | 66
Median cleft lip/palate 1 | 3
Microcephaly 1 | 166
Microdontia (disorder) 1 | 59
Microphthalmia 1 | 76
Midface retrusion 1 | 105
Mitral valve stenosis 1 | 14
Neoplasm Invasiveness 1 | 161
Neurodegenerative disease 1 | 414
Oligodontia 1 | 24
Periventricular nodular heterotopia 1 | 30
Precancerous Conditions 1 | 80
Pseudobulbar palsy 1 | 11
Retinitis pigmentosa Y-linked 1 | 9
Retrusion of upper jaw bones 1 | 66
SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR 1 | 5
Seizures 1 | 596
Semilobar Holoprosencephaly 1 | 14
Small midface 1 | 105
Spastic Quadriplegia 1 | 42
Stomach Neoplasms 1 | 300
Strabismus 1 | 270
Variable expressivity 1 | 157
atypical teratoid/rhabdoid tumor 1 | 357
immunodeficiency-centromeric instability-facial anomalies syndrome 1 | 16
pediatric high grade glioma 1 | 1,064
posterior fossa group B ependymoma 1 | 416
substance-related disorder 1 | 162
tuberculosis and treatment for 3 months 1 | 179
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 10 | 16,909
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Cardiovascular System 9 | 15,192
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Urinary Tract 9 | 16,678

Target Family

Non-IDG 3 | 12,091
Epigenetic 2 | 242
Nuclear Receptor 2 | 48
Transcription Factor 2 | 1,400
Kinase 1 | 634

GO Function

transcription corepressor bind... 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
PHD finger protein 12 PHF12 Tbio Epigenetic -2.57717 385.3 70
Hepatoma-derived growth factor HDGF Tbio Epigenetic -2.08423 132.3 192
Homeobox protein SIX3 SIX3 Tbio Transcription Factor -2.84681 686.8 212
Nuclear receptor subfamily 1 group D member 1 NR1D1 Tchem Nuclear Receptor -1.95952 81.6 389
Cell division cycle 5-like protein CDC5L Tbio Transcription Factor -2.15843 139.9 212
Serine/threonine-protein kinase Nek6 NEK6 Tchem Kinase -1.53724 36.6 188
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.72599 482.7 786
Nuclear receptor ROR-alpha RORA Tchem Nuclear Receptor -2.23961 154.7 386
Small ubiquitin-related modifier 2 SUMO2 Tbio Non-IDG -2.19033 136.7 613
Leucine repeat adapter protein 25 FAM89B Tbio Non-IDG -0.78837 6.19 60