Development Level

Tbio 159 | 11,445
Tchem 22 | 1,598
Tdark 12 | 6,588
Tclin 7 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 6 | 499
abnormal behavior 5 | 298
decreased vertical activity 5 | 208
enlarged heart 5 | 210
abnormal heart morphology 4 | 162
decreased total body fat amoun... 4 | 207
embryonic lethality prior to t... 4 | 278
increased startle reflex 4 | 112
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
increased bone mineral content 3 | 108
increased circulating choleste... 3 | 66
increased circulating triglyce... 3 | 42
abnormal cornea morphology 2 | 31
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
decreased body weight 2 | 161
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
increased neutrophil cell numb... 2 | 46
thin ventricular wall 2 | 24
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart left ventricle ... 1 | 16
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal motor capabilities-co... 1 | 5
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
brachydactyly 1 | 19
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating glycerol... 1 | 9
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
limb grasping 1 | 41
long tibia 1 | 25
microphthalmia 1 | 26
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
small superior vagus ganglion 1 | 74
small thymus 1 | 16
syndactyly 1 | 23
urinary bladder obstruction 1 | 4

Disease

Carcinoma 136 | 11,493
ovarian cancer 109 | 8,520
osteosarcoma 93 | 7,950
glioblastoma 80 | 5,792
psoriasis 80 | 6,694
medulloblastoma, large-cell 76 | 6,241
Cancer 71 | 2,499
atypical teratoid / rhabdoid tumor 69 | 5,112
lung cancer 66 | 4,740
adult high grade glioma 52 | 3,801
ependymoma 52 | 4,679
malignant mesothelioma 52 | 3,232
group 3 medulloblastoma 50 | 4,104
Breast cancer 48 | 3,578
invasive ductal carcinoma 43 | 2,951
primitive neuroectodermal tumor 39 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
non-small cell lung cancer 36 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
pancreatic cancer 34 | 2,398
lung carcinoma 32 | 2,843
pituitary cancer 32 | 1,972
subependymal giant cell astrocytoma 32 | 2,287
Pick disease 31 | 1,894
juvenile dermatomyositis 31 | 1,187
lung adenocarcinoma 31 | 2,716
Astrocytoma, Pilocytic 30 | 3,081
cystic fibrosis 30 | 1,696
oligodendroglioma 29 | 2,850
group 4 medulloblastoma 28 | 1,855
tuberculosis 28 | 2,010
Multiple myeloma 27 | 1,332
astrocytoma 27 | 1,146
interstitial cystitis 27 | 2,312
spina bifida 25 | 1,074
Kidney cancer 24 | 2,613
diabetes mellitus 24 | 1,728
astrocytic glioma 23 | 2,597
primary pancreatic ductal adenocarcinoma 23 | 1,109
Rheumatoid arthritis 22 | 1,191
ductal carcinoma in situ 22 | 1,745
ulcerative colitis 22 | 1,819
colon cancer 21 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
Intellectual disability 20 | 1,016
acute quadriplegic myopathy 20 | 1,158
adrenocortical carcinoma 18 | 1,428
breast carcinoma 16 | 1,638
dermatomyositis 16 | 966
Breast Neoplasms 15 | 445
active ulcerative colitis 15 | 764
cutaneous lupus erythematosus 15 | 1,057
acute myeloid leukemia 14 | 783
non primary Sjogren syndrome sicca 14 | 891
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mammary Neoplasms 13 | 425
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Poor school performance 13 | 645
Prostatic Neoplasms 13 | 495
Waldenstrons macroglobulinemia 13 | 765
aldosterone-producing adenoma 13 | 665
Schizophrenia 12 | 1,160
Short stature 12 | 531
active Crohn's disease 12 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 510
pediatric high grade glioma 12 | 1,064
primary Sjogren syndrome 12 | 735
Bipolar Disorder 11 | 666
Chronic Lymphocytic Leukemia 11 | 262
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Muscle hypotonia 11 | 571
gastric cancer 11 | 459
gastric carcinoma 11 | 807
medulloblastoma 11 | 720
nasopharyngeal carcinoma 11 | 1,058
Alzheimer's disease 10 | 658
Atopic dermatitis 10 | 952
Down syndrome 10 | 499
Polycystic ovary syndrome 10 | 360
posterior fossa group A ependymoma 10 | 468
Blepharoptosis 9 | 231
Concave bridge of nose 9 | 195
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Endometriosis 9 | 540
Obesity 9 | 678
atypical teratoid/rhabdoid tumor 9 | 357
Autosomal recessive predisposition 8 | 1,442
Epilepsy 8 | 792
Heart disease 8 | 306
Liver cancer 8 | 604
Myocardial Ischemia 8 | 169
Small head 8 | 374
esophageal adenocarcinoma 8 | 737
fibroadenoma 8 | 559

Tissue

Endocrine System 193 | 18,159
Female tissues 187 | 17,400
Skin and soft tissues 187 | 17,230
Digestive Tract 186 | 17,369
Male tissues 184 | 17,142
Blood and immune system 183 | 16,909
Liver and Pancreas 183 | 16,750
Nervous System 180 | 16,725
Urinary Tract 180 | 16,678
Respiratory system 179 | 16,393
Cardiovascular System 172 | 15,192

Target Family

Non-IDG 86 | 12,091
Transcription Factor 71 | 1,400
Epigenetic 18 | 242
Enzyme 12 | 4,145
Nuclear Receptor 7 | 48
Kinase 3 | 634
TF/Epigenetic 2 | 38
Ion Channel 1 | 344

GO Function

transcription corepressor acti... 200 | 200
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
CASP8-associated protein 2 CASP8AP2 Tbio Non-IDG 0.00000 0
SKI family transcriptional corepressor 2 SKOR2 Tbio Non-IDG -0.52843 4.42 59
Dr1-associated corepressor DRAP1 Tbio Non-IDG -1.11644 10.8 122
Zinc finger protein ZFPM2 ZFPM2 Tbio Transcription Factor -1.78912 62.9 93
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.47780 298.9 332
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.20048 15.1 221
Transcription initiation factor TFIID subunit 9B TAF9B Tbio Non-IDG -1.38372 23.5 105
Protein SCAI SCAI Tbio Non-IDG -2.49540 300.3 22
Homeobox protein CDX-2 CDX2 Tbio Transcription Factor -2.91273 837.0 699