Development Level

Tbio 52 | 11,445
Tdark 3 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal cornea morphology 2 | 31
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal placenta size 2 | 20
cardiovascular system phenotyp... 2 | 36
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged uterus 2 | 11
hydrometra 2 | 53
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
pale yolk sac 2 | 25
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal forebrain development 1 | 20
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal pancreas morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal tail morphology 1 | 25
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
female infertility 1 | 60
increased B cell number 1 | 9
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating magnesiu... 1 | 10
increased heart rate 1 | 23
increased heart weight 1 | 62
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
pale liver 1 | 6
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
shortened RR interval 1 | 17
shortened ST segment 1 | 10
small kidney 1 | 16
thin ventricular wall 1 | 24

Disease

Carcinoma 40 | 11,493
ovarian cancer 36 | 8,520
osteosarcoma 35 | 7,950
medulloblastoma, large-cell 27 | 6,241
psoriasis 27 | 6,694
glioblastoma 20 | 5,792
lung cancer 20 | 4,740
malignant mesothelioma 19 | 3,232
Breast cancer 17 | 3,578
atypical teratoid / rhabdoid tumor 17 | 5,112
group 3 medulloblastoma 14 | 4,104
Pick disease 13 | 1,894
non-small cell lung cancer 13 | 2,890
primitive neuroectodermal tumor 13 | 3,035
astrocytoma 12 | 1,146
invasive ductal carcinoma 12 | 2,951
ulcerative colitis 12 | 1,819
Kidney cancer 11 | 2,613
ependymoma 11 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
pancreatic cancer 11 | 2,398
Rheumatoid arthritis 10 | 1,191
lung adenocarcinoma 10 | 2,716
subependymal giant cell astrocytoma 10 | 2,287
Cancer 9 | 2,499
colon cancer 9 | 1,478
lung carcinoma 9 | 2,843
oligodendroglioma 9 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
cystic fibrosis 8 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
juvenile dermatomyositis 8 | 1,187
pituitary cancer 8 | 1,972
spina bifida 8 | 1,074
Astrocytoma, Pilocytic 7 | 3,081
Endometriosis 7 | 540
adult high grade glioma 7 | 3,801
dermatomyositis 7 | 966
interstitial cystitis 7 | 2,312
tuberculosis 7 | 2,010
Epilepsy 6 | 792
Intellectual disability 6 | 1,016
active Crohn's disease 6 | 922
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
diabetes mellitus 6 | 1,728
group 4 medulloblastoma 6 | 1,855
Autosomal recessive predisposition 5 | 1,442
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Immune system cancer 5 | 140
Mental and motor retardation 5 | 608
Multiple myeloma 5 | 1,332
Schizophrenia 5 | 1,160
acute quadriplegic myopathy 5 | 1,158
ductal carcinoma in situ 5 | 1,745
esophageal adenocarcinoma 5 | 737
primary Sjogren syndrome 5 | 735
primary pancreatic ductal adenocarcinoma 5 | 1,109
progressive supranuclear palsy 5 | 676
Alzheimer's disease 4 | 658
Autistic Disorder 4 | 364
Endometrial cancer 4 | 311
Liver Cirrhosis, Experimental 4 | 769
Liver cancer 4 | 604
Seizures 4 | 596
adrenocortical carcinoma 4 | 1,428
nasopharyngeal carcinoma 4 | 1,058
Cleft Palate 3 | 271
Depressive disorder 3 | 409
Dull intelligence 3 | 645
Failure to gain weight 3 | 365
Low intelligence 3 | 645
Lymphoid leukemia 3 | 160
Major Depressive Disorder 3 | 301
Mental Depression 3 | 333
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Mood Disorders 3 | 184
Pediatric failure to thrive 3 | 365
Polycystic ovary syndrome 3 | 360
Poor school performance 3 | 645
Short philtrum 3 | 53
Uranostaphyloschisis 3 | 167
active ulcerative colitis 3 | 764
atypical teratoid/rhabdoid tumor 3 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
cutaneous lupus erythematosus 3 | 1,057
glioblastoma multiforme 3 | 142
non primary Sjogren syndrome sicca 3 | 891
pancreatic carcinoma 3 | 562
pediatric high grade glioma 3 | 1,064
posterior fossa group A ependymoma 3 | 468
Contact Dermatitis 2 | 81
Down syndrome 2 | 499
Juvenile arthritis 2 | 126
chronic rhinosinusitis 2 | 512
fibroadenoma 2 | 559
hepatocellular carcinoma 2 | 547

Tissue

Blood and immune system 53 | 16,909
Digestive Tract 53 | 17,369
Female tissues 53 | 17,400
Male tissues 53 | 17,142
Nervous System 53 | 16,725
Endocrine System 52 | 18,159
Liver and Pancreas 52 | 16,750
Respiratory system 52 | 16,393
Skin and soft tissues 52 | 17,230
Urinary Tract 52 | 16,678
Cardiovascular System 51 | 15,192

Target Family

Non-IDG 22 | 12,091
Enzyme 14 | 4,145
Transcription Factor 11 | 1,400
Epigenetic 7 | 242
TF/Epigenetic 1 | 38
Transporter 1 | 473

GO Function

transcription cofactor activit... 56 | 56
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA-binding protein Raly RALY Tbio Non-IDG -1.12263 14.4 176
Staphylococcal nuclease domain-containing protein 1 SND1 Tbio Epigenetic -2.35812 225.9 175
Mediator of RNA polymerase II transcription subunit 16 MED16 Tbio Enzyme -0.82499 7.04 154
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
NF-kappa-B inhibitor zeta NFKBIZ Tbio Non-IDG -2.14151 143.2 111
Mediator of RNA polymerase II transcription subunit 13 MED13 Tbio Enzyme -1.52250 26.0 53
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
Protein BTG1 BTG1 Tbio Non-IDG 0.13 1.00 154
Chloride anion exchanger SLC26A3 Tbio Transporter -2.83731 669.8 49
LIM domain-binding protein 2 LDB2 Tbio Non-IDG -1.58628 38.6 191