Development Level

Tbio 199 | 11,651
Tchem 35 | 1,388
Tdark 9 | 6,593
Tclin 6 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 26 | 979
abnormal behavior 9 | 298
abnormal embryo size 8 | 220
decreased vertical activity 6 | 208
increased total body fat amoun... 6 | 134
preweaning lethality, incomple... 6 | 499
decreased body weight 5 | 161
decreased circulating glucose ... 5 | 126
decreased leukocyte cell numbe... 5 | 73
abnormal bone structure 4 | 187
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
prenatal lethality prior to he... 4 | 87
abnormal bone mineralization 3 | 38
abnormal coat-hair pigmentatio... 3 | 64
decreased bone mineral content 3 | 151
decreased caudal vertebrae num... 3 | 53
decreased circulating serum al... 3 | 82
decreased lean body mass 3 | 135
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
hydrometra 3 | 53
hyperactivity 3 | 148
increased circulating alkaline... 3 | 122
increased circulating sodium l... 3 | 71
increased hemoglobin content 3 | 45
increased startle reflex 3 | 112
abnormal cranium morphology 2 | 36
abnormal eye morphology 2 | 68
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal vertebrae morphology 2 | 18
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased neutrophil cell numb... 2 | 42
impaired glucose tolerance 2 | 75
increased blood uric acid leve... 2 | 5
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
mammalian phenotype 2 | 17
pale yolk sac 2 | 25
short tibia 2 | 97
small superior vagus ganglion 2 | 74
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
absent vibrissae 1 | 12
corneal opacity 1 | 32
decreased circulating creatine... 1 | 4
decreased erythrocyte cell num... 1 | 62
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hematocrit 1 | 46
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 170 | 11,493
ovarian cancer 147 | 8,520
osteosarcoma 141 | 7,950
psoriasis 108 | 6,694
medulloblastoma, large-cell 95 | 6,241
lung cancer 89 | 4,740
Cancer 84 | 2,499
glioblastoma 82 | 5,792
atypical teratoid / rhabdoid tumor 74 | 5,112
group 3 medulloblastoma 65 | 4,104
Breast cancer 61 | 3,578
malignant mesothelioma 57 | 3,232
ependymoma 52 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
Kidney cancer 46 | 2,613
adult high grade glioma 43 | 3,801
oligodendroglioma 43 | 2,850
primitive neuroectodermal tumor 42 | 3,035
astrocytic glioma 39 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
invasive ductal carcinoma 38 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
Intellectual disability 34 | 1,016
Multiple myeloma 33 | 1,332
lung adenocarcinoma 33 | 2,716
pituitary cancer 33 | 1,972
astrocytoma 32 | 1,146
group 4 medulloblastoma 32 | 1,855
non-small cell lung cancer 32 | 2,890
Rheumatoid arthritis 31 | 1,191
pancreatic cancer 31 | 2,398
Pick disease 30 | 1,894
subependymal giant cell astrocytoma 30 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,962
Astrocytoma, Pilocytic 28 | 3,081
acute quadriplegic myopathy 28 | 1,158
juvenile dermatomyositis 28 | 1,187
dermatomyositis 27 | 966
Dull intelligence 26 | 645
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Poor school performance 26 | 645
diabetes mellitus 26 | 1,728
lung carcinoma 26 | 2,843
spina bifida 26 | 1,074
Obesity 24 | 678
tuberculosis 24 | 2,010
ulcerative colitis 23 | 1,819
Autosomal recessive predisposition 22 | 1,442
Waldenstrons macroglobulinemia 22 | 765
breast carcinoma 22 | 1,638
Breast Neoplasms 21 | 445
colon cancer 21 | 1,478
interstitial cystitis 21 | 2,312
Mammary Neoplasms 20 | 425
ductal carcinoma in situ 20 | 1,745
Broad flat nasal bridge 18 | 236
Nasal bridge wide 18 | 236
Seizures 18 | 596
Small head 18 | 374
Cognitive delay 17 | 608
Epilepsy 17 | 792
Global developmental delay 17 | 608
Mental and motor retardation 17 | 608
Schizophrenia 17 | 1,160
primary pancreatic ductal adenocarcinoma 17 | 1,109
Cryptorchidism 16 | 296
Liver carcinoma 16 | 240
Muscle hypotonia 16 | 571
pediatric high grade glioma 16 | 1,064
Carcinoma, Hepatocellular 15 | 228
Endometriosis 15 | 540
Prostatic Neoplasms 15 | 495
Short stature 15 | 531
Strabismus 15 | 270
Nystagmus 14 | 317
acute myeloid leukemia 14 | 783
aldosterone-producing adenoma 14 | 665
cystic fibrosis 14 | 1,696
Alzheimer's disease 13 | 658
hepatocellular carcinoma 13 | 547
non primary Sjogren syndrome sicca 13 | 891
Cleft Palate 12 | 271
Melanoma 12 | 711
gastric cancer 12 | 459
medulloblastoma 12 | 720
posterior fossa group A ependymoma 12 | 468
primary Sjogren syndrome 12 | 735
Congenital hypoplasia of penis 11 | 176
Curvature of spine 11 | 282
Hypoplastic mandible condyle 11 | 275
Infant, Small for Gestational Age 11 | 176
Intrauterine retardation 11 | 176
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
adrenocortical carcinoma 11 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
cutaneous lupus erythematosus 11 | 1,057
nasopharyngeal carcinoma 11 | 1,058

Tissue

Digestive Tract 245 | 17,369
Endocrine System 245 | 18,159
Female tissues 242 | 17,400
Skin and soft tissues 242 | 17,230
Blood and immune system 239 | 16,909
Male tissues 239 | 17,142
Liver and Pancreas 237 | 16,750
Respiratory system 236 | 16,393
Urinary Tract 234 | 16,678
Nervous System 232 | 16,725
Cardiovascular System 230 | 15,192

Target Family

Non-IDG 108 | 12,091
Transcription Factor 61 | 1,400
Enzyme 37 | 4,145
Epigenetic 20 | 242
Nuclear Receptor 13 | 48
Kinase 5 | 634
TF/Epigenetic 5 | 38

GO Function

transcription coactivator acti... 249 | 249
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Nuclear receptor coactivator 4 NCOA4 Tbio Non-IDG -2.20245 136.0 283
E3 ubiquitin-protein ligase DTX1 DTX1 Tbio Enzyme -2.07595 115.2 134
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L TAF6L Tdark Enzyme 0.55 0.23 173
Protein ecdysoneless homolog ECD Tbio Non-IDG -0.72245 9.93 113
Nuclear receptor coactivator 3 NCOA3 Tbio Epigenetic -2.64583 480.2 417
Cbp/p300-interacting transactivator 4 CITED4 Tbio Non-IDG -1.07712 14.3 100