Development Level

Tbio 4 | 11,445

IMPC Phenotype

abnormal embryo size 2 | 220
abnormal placenta size 2 | 20
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
pale yolk sac 2 | 25
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged uterus 1 | 11
hydrometra 1 | 53
increased monocyte cell number 1 | 63
pale liver 1 | 6
pallor 1 | 34
preweaning lethality, complete... 1 | 979
prolonged PR interval 1 | 15
small superior vagus ganglion 1 | 74

Disease

Carcinoma 4 | 11,493
osteosarcoma 4 | 7,950
Kidney cancer 3 | 2,613
astrocytoma 3 | 1,146
atypical teratoid / rhabdoid tumor 3 | 5,112
glioblastoma 3 | 5,792
lung cancer 3 | 4,740
medulloblastoma, large-cell 3 | 6,241
ovarian cancer 3 | 8,520
psoriasis 3 | 6,694
Endometriosis 2 | 540
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
acute quadriplegic myopathy 2 | 1,158
group 3 medulloblastoma 2 | 4,104
primitive neuroectodermal tumor 2 | 3,035
Androgen insensitivity syndrome 1 | 12
Astrocytoma, Pilocytic 1 | 3,081
Breast Neoplasms 1 | 445
Bulimia nervosa 1 | 14
Cancer 1 | 2,499
Carcinoma, Hepatocellular 1 | 228
Cardiomyopathy 1 | 116
Cardiomyopathy, Dilated 1 | 83
Cardiomyopathy, Dilated, 1AA 1 | 1
Chemical and Drug Induced Liver Injury 1 | 195
Crohn's disease 1 | 321
Dilated cardiomyopathy 1 | 56
Endocardial Fibroelastosis 1 | 9
Endomyocardial Fibrosis 1 | 13
Familial isolated dilated cardiomyopathy 1 | 41
Gaucher disease type 1 1 | 180
Hiatus hernia 1 | 7
Highly variable clinical phenotype 1 | 150
Highly variable phenotype and severity 1 | 150
Highly variable phenotype, even within families 1 | 150
Hypertrophic Cardiomyopathy 1 | 117
Infantile onset spinocerebellar ataxia 1 | 7
LEFT VENTRICULAR NONCOMPACTION 10 1 | 40
LEFT VENTRICULAR NONCOMPACTION 8 1 | 40
Liver carcinoma 1 | 240
Mammary Neoplasms 1 | 425
Multiple myeloma 1 | 1,332
Myopathy 1 | 185
Phenotypic variability 1 | 150
Prostatic Neoplasms 1 | 495
aldosterone-producing adenoma 1 | 665
dermatomyositis 1 | 966
dilated cardiomyopathy 1AA 1 | 1
ependymoma 1 | 4,679
hereditary spastic paraplegia 1 | 318
interstitial cystitis 1 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
lung adenocarcinoma 1 | 2,716
malignant mesothelioma 1 | 3,232
medulloblastoma 1 | 720
non primary Sjogren syndrome sicca 1 | 891
non-small cell lung carcinoma 1 | 317
pediatric high grade glioma 1 | 1,064
pituitary cancer 1 | 1,972
spina bifida 1 | 1,074
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Enzyme 2 | 4,145
Non-IDG 2 | 12,091

GO Function

thyroid hormone receptor coact... 4 | 4
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mediator of RNA polymerase II transcription subunit 16 MED16 Tbio Enzyme -0.82499 7.04 154
Alpha-actinin-2 ACTN2 Tbio Non-IDG -1.89804 72.9 245
Nuclear receptor coactivator 2 NCOA2 Tbio Non-IDG -2.17388 142.6 197
Mediator of RNA polymerase II transcription subunit 1 MED1 Tbio Enzyme -1.89424 83.3 350