Development Level

Tbio 3 | 11,445
Tclin 3 | 613
Tchem 1 | 1,598

IMPC Phenotype

abnormal behavior 2 | 298
abnormal behavioral response t... 1 | 66
decreased circulating serum al... 1 | 82
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Carcinoma 6 | 11,493
Cancer 4 | 2,499
interstitial cystitis 4 | 2,312
lung cancer 4 | 4,740
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Endometriosis 3 | 540
glioblastoma 3 | 5,792
malignant mesothelioma 3 | 3,232
medulloblastoma, large-cell 3 | 6,241
psoriasis 3 | 6,694
Abdomen distended 2 | 43
Breast cancer 2 | 3,578
Chemical and Drug Induced Liver Injury 2 | 195
Cholestasis 2 | 155
Coarse facial features 2 | 108
Congenital hypothyroidism 2 | 26
Constipation 2 | 181
Delayed bone age 2 | 136
Diagnostic Test for Thyroid Dysfunction 2 | 3
Diaphragmatic Hernia 2 | 40
Dyschezia 2 | 135
Fatty liver disease 2 | 103
Feeding difficulties 2 | 127
Goiter 2 | 38
Hernia, Diaphragmatic 2 | 40
Hyperlipidemia 2 | 43
Hyperthyroidism 2 | 53
Hyperthyroxinemia 2 | 9
Hypothyroidism 2 | 122
Icterus 2 | 82
Large bregma sutures 2 | 46
Large fontanelle 2 | 46
Large, late-closing fontanelle 2 | 46
Liver neoplasms 2 | 130
Macroglossia 2 | 65
Malignant tumor of thyroid gland 2 | 3
Mild Hypothyroidism 2 | 2
Muscle hypotonia 2 | 571
Myxedema 2 | 11
Myxedema coma 2 | 2
Obesity 2 | 678
Peripheral resistance to thyroid hormones 2 | 2
Simple goiter 2 | 2
Sleep disturbances 2 | 37
T3 Suppression for Thyroid Function Test 2 | 2
Thickened facial skin with coarse facial features 2 | 108
Thyroid Hormone Resistance Syndrome 2 | 5
Umbilical hernia 2 | 93
Wide bregma sutures 2 | 46
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
breast carcinoma 2 | 1,638
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
hereditary spastic paraplegia 2 | 318
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung adenocarcinoma 2 | 2,716
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
ulcerative colitis 2 | 1,819
Adenoma, Liver Cell 1 | 8
Bilirubin metabolic disorder 1 | 41
Breast Neoplasms 1 | 445
Congenital deafness 1 | 185
Craniofacial Abnormalities 1 | 151
Crohn Disease 1 | 45
Deafness 1 | 198
Dry skin 1 | 75
Enhanced S-cone syndrome 1 | 17
Extravasation of Diagnostic and Therapeutic Materials 1 | 6
Fragile X syndrome 1 | 34
Gaucher disease type 1 1 | 180
Growth delay 1 | 114
Growth failure 1 | 114
Hearing Loss, Partial 1 | 185
Insulin Resistance 1 | 72
Intestinal Neoplasms 1 | 12
Intrahepatic cholestasis 1 | 20
Kleefstra syndrome 1 | 12
Late tooth eruption 1 | 61
Leber congenital amaurosis 1 | 69
Liver disease 1 | 237
Liver diseases 1 | 87
Mammary Neoplasms 1 | 425
Metabolic syndrome X 1 | 52
Poor growth 1 | 114
Precancerous Conditions 1 | 80
Sarcoma 1 | 62
Sensorineural Hearing Loss (disorder) 1 | 284
Somatic mutation 1 | 61
Sprengel deformity 1 | 16
Stippled epiphyses 1 | 28
Thyrotoxicosis 1 | 38
Vertigo 1 | 29
Very poor growth 1 | 114
Xerosis 1 | 75
hearing impairment 1 | 199

Tissue

Blood and immune system 7 | 16,909
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678
Cardiovascular System 6 | 15,192
Nervous System 6 | 16,725

Target Family

Nuclear Receptor 6 | 48
Epigenetic 1 | 242

GO Function

thyroid hormone receptor activ... 7 | 7
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bromodomain-containing protein 8 BRD8 Tbio Epigenetic -0.69185 6.07 117
Nuclear receptor subfamily 4 group A member 3 NR4A3 Tbio Nuclear Receptor -2.02752 112.7 289
Nuclear receptor subfamily 1 group I member 3 NR1I3 Tchem Nuclear Receptor -2.57140 281.2 304
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
Thyroid hormone receptor alpha THRA Tclin Nuclear Receptor -2.72292 527.4 453
Thyroid hormone receptor beta THRB Tclin Nuclear Receptor -2.82486 627.3 399
Nuclear receptor subfamily 2 group F member 6 NR2F6 Tbio Nuclear Receptor -1.64057 0.00000 250