Development Level

Tbio 7 | 11,651
Tdark 2 | 6,593
Tchem 1 | 1,388
Tclin 1 | 612

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eyelid morphology 1 | 7
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal head size 1 | 6
abnormal snout morphology 1 | 23
anophthalmia 1 | 33
cleft palate 1 | 8
decreased lean body mass 1 | 135
embryonic lethality prior to t... 1 | 278
facial cleft 1 | 3
increased grip strength 1 | 41
increased or absent threshold ... 1 | 101
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
prolonged PQ interval 1 | 5
short tibia 1 | 97
small adrenal glands 1 | 16

Disease

ovarian cancer 6 | 8,520
Carcinoma 5 | 11,493
Cancer 4 | 2,499
atypical teratoid / rhabdoid tumor 4 | 5,112
Breast cancer 3 | 3,578
Multiple myeloma 3 | 1,332
acute quadriplegic myopathy 3 | 1,158
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung cancer 3 | 4,740
osteosarcoma 3 | 7,950
Colorectal Neoplasms 2 | 243
Contact Dermatitis 2 | 81
Dermatitis, Contact 2 | 71
Male infertility 2 | 206
Retinitis Pigmentosa 2 | 226
Vascular disease 2 | 319
adult high grade glioma 2 | 3,801
diabetes mellitus 2 | 1,728
esophageal adenocarcinoma 2 | 737
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
psoriasis 2 | 6,694
Acute Lung Injury 1 | 22
Acute myelomonocytic leukemia, FAB M4 1 | 1
Acute promyelocytic leukemia, FAB M3 1 | 11
Adenoma 1 | 167
Alopecia 1 | 115
Amyotrophic lateral sclerosis 1 | 451
Barrett's esophagus 1 | 182
Blindness 1 | 88
Bronchopulmonary Dysplasia 1 | 3
Carcinoma, Lewis Lung 1 | 1
Cardiomyopathy, Dilated 1 | 83
Cysticercosis 1 | 14
Degenerative polyarthritis 1 | 115
Depressive Symptoms 1 | 28
Duchenne muscular dystrophy 1 | 601
Echinococcosis 1 | 26
Epilepsy 1 | 792
Familial glucocorticoid deficiency 1 | 4
Familial isolated dilated cardiomyopathy 1 | 41
Fascioliasis 1 | 17
GLUCOCORTICOID DEFICIENCY 1 1 | 5
Glaucoma 1 | 239
Glaucoma, Open-Angle 1 | 11
Glaucoma, Primary Open Angle 1 | 8
Goiter 1 | 38
Hyperthyroidism 1 | 53
Hyperthyroxinemia 1 | 9
Hypothyroidism 1 | 122
IMAGe syndrome 1 | 8
Infertility 1 | 188
LEFT VENTRICULAR NONCOMPACTION 10 1 | 40
LEFT VENTRICULAR NONCOMPACTION 8 1 | 40
Leukopenia 1 | 72
Liver diseases 1 | 87
Mesothelioma 1 | 38
Mesothelioma, Malignant 1 | 105
Myocardial Ischemia 1 | 169
Neoplasm Invasiveness 1 | 161
Neurodegenerative disease 1 | 414
Osteoarthritis 1 | 184
Polycystic ovary syndrome 1 | 360
Primary ciliary dyskinesia 1 | 76
Prostatic Neoplasms 1 | 495
Retinitis pigmentosa 29 1 | 6
Robinow syndrome 1 | 11
Schistosomiasis 1 | 35
Thyrotoxicosis 1 | 38
Vulvitis 1 | 4
Waldenstrons macroglobulinemia 1 | 765
astrocytic glioma 1 | 2,597
colon cancer 1 | 1,478
cystic fibrosis 1 | 1,696
ependymoma 1 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
invasive ductal carcinoma 1 | 2,951
non primary Sjogren syndrome sicca 1 | 891
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
pancreatic cancer 1 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
pituitary cancer 1 | 1,972
posterior fossa group A ependymoma 1 | 468
primitive neuroectodermal tumor 1 | 3,035
spina bifida 1 | 1,074
tuberculosis 1 | 2,010
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 11 | 16,909
Endocrine System 11 | 18,159
Male tissues 11 | 17,142
Urinary Tract 11 | 16,678
Digestive Tract 10 | 17,369
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Cardiovascular System 9 | 15,192

Target Family

Non-IDG 8 | 12,091
Enzyme 3 | 4,145

GO Function

thioredoxin-disulfide reductas... 11 | 11
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thioredoxin domain-containing protein 8 TXNDC8 Tbio Non-IDG -0.64836 5.23 17
Nucleoredoxin-like protein 2 NXNL2 Tdark Non-IDG -0.41218 3.20 114
Thioredoxin TXN Tchem Non-IDG -3.19880 1494.7 530
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 19
Thioredoxin reductase 3 TXNRD3 Tdark Enzyme -1.72626 60.0 0
Thioredoxin-like protein 1 TXNL1 Tbio Non-IDG -2.32888 224.7 143
Thioredoxin reductase-like selenoprotein T SELENOT Tbio Non-IDG -1.36965 25.6 0
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
Thioredoxin reductase 1, cytoplasmic TXNRD1 Tclin Enzyme -2.28524 208.2 308
Nucleoredoxin-like protein 1 NXNL1 Tbio Non-IDG -1.13331 14.8 107