Development Level

Tbio 53 | 11,445
Tdark 24 | 6,588
Tchem 9 | 1,598

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal behavior 4 | 298
decreased body weight 4 | 161
decreased lean body mass 4 | 135
hypoactivity 4 | 132
decreased leukocyte cell numbe... 3 | 73
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
preweaning lethality, incomple... 3 | 499
thrombocytosis 3 | 27
abnormal coat-hair pigmentatio... 2 | 64
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
hyperactivity 2 | 148
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased mean platelet volume 2 | 45
increased total body fat amoun... 2 | 134
long tibia 2 | 25
male infertility 2 | 123
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal pelvic girdle bone mo... 1 | 12
abnormal rib morphology 1 | 10
abnormal spine curvature 1 | 9
abnormal tail morphology 1 | 25
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
abnormal vocalization 1 | 21
corneal opacity 1 | 32
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
female infertility 1 | 60
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 12
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Carcinoma 57 | 11,493
ovarian cancer 46 | 8,520
osteosarcoma 35 | 7,950
medulloblastoma, large-cell 27 | 6,241
glioblastoma 25 | 5,792
atypical teratoid / rhabdoid tumor 24 | 5,112
psoriasis 16 | 6,694
ependymoma 15 | 4,679
lung cancer 15 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Kidney cancer 13 | 2,613
adult high grade glioma 13 | 3,801
Breast cancer 12 | 3,578
Pick disease 12 | 1,894
group 3 medulloblastoma 12 | 4,104
oligodendroglioma 12 | 2,850
subependymal giant cell astrocytoma 12 | 2,287
Cancer 11 | 2,499
astrocytic glioma 11 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
juvenile dermatomyositis 11 | 1,187
malignant mesothelioma 11 | 3,232
primitive neuroectodermal tumor 11 | 3,035
group 4 medulloblastoma 10 | 1,855
lung adenocarcinoma 9 | 2,716
spina bifida 9 | 1,074
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
Rheumatoid arthritis 6 | 1,191
dermatomyositis 6 | 966
Astrocytoma, Pilocytic 5 | 3,081
Parkinson's disease 5 | 392
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
diabetes mellitus 5 | 1,728
progressive supranuclear palsy 5 | 676
Machado-Joseph disease 4 | 18
Multiple myeloma 4 | 1,332
Waldenstrons macroglobulinemia 4 | 765
acute quadriplegic myopathy 4 | 1,158
hereditary spastic paraplegia 4 | 318
invasive ductal carcinoma 4 | 2,951
pituitary cancer 4 | 1,972
tuberculosis 4 | 2,010
tuberculosis and treatment for 6 months 4 | 409
ulcerative colitis 4 | 1,819
Alzheimer's disease 3 | 658
Amyotrophic lateral sclerosis 3 | 451
Atopic dermatitis 3 | 952
Babinski Reflex 3 | 100
Carcinoma, Hepatocellular 3 | 228
Crohn's disease 3 | 321
Endometrial cancer 3 | 311
Gaucher disease type 1 3 | 180
Liver cancer 3 | 604
Liver carcinoma 3 | 240
Melanoma 3 | 711
Neurodegenerative disease 3 | 414
Skin cancer 3 | 469
Spinocerebellar ataxia type 7 3 | 13
aldosterone-producing adenoma 3 | 665
astrocytoma 3 | 1,146
cystic fibrosis 3 | 1,696
medulloblastoma 3 | 720
Arsenic Poisoning 2 | 62
Asthma 2 | 385
Atrophy of cerebellum 2 | 103
Autosomal dominant cerebellar ataxia 2 | 33
Bipolar Disorder 2 | 666
Bladder Neoplasm 2 | 112
Cerebellar degeneration 2 | 103
Choreatic disease 2 | 52
Congestive heart failure 2 | 113
Decreased visual acuity, progressive 2 | 36
Deglutition Disorders 2 | 132
Dermatologic disorders 2 | 93
Immune system cancer 2 | 140
Infratentorial atrophy 2 | 103
Lung Neoplasms 2 | 232
Mental Depression 2 | 333
Nerve Degeneration 2 | 121
Neuropathy 2 | 261
Panic disorder 2 | 61
Progressive disorder 2 | 142
Progressive visual loss 2 | 36
Schizophrenia 2 | 1,160
Skin Diseases 2 | 71
Urinary Bladder Neoplasms 2 | 114
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
esophageal adenocarcinoma 2 | 737
gastric cancer 2 | 459
inflammatory breast cancer 2 | 286
interstitial cystitis 2 | 2,312
non-small cell lung carcinoma 2 | 317
primary pancreatic ductal adenocarcinoma 2 | 1,109

Tissue

Endocrine System 68 | 18,159
Female tissues 66 | 17,400
Blood and immune system 65 | 16,909
Nervous System 65 | 16,725
Digestive Tract 64 | 17,369
Liver and Pancreas 64 | 16,750
Male tissues 64 | 17,142
Respiratory system 64 | 16,393
Skin and soft tissues 64 | 17,230
Cardiovascular System 63 | 15,192
Urinary Tract 63 | 16,678

Target Family

Enzyme 64 | 4,145
Non-IDG 19 | 12,091
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

GO Function

thiol-dependent ubiquitinyl hy... 86 | 86
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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