Development Level

Tbio 64 | 11,445
Tchem 9 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
decreased lean body mass 5 | 135
abnormal behavior 4 | 298
decreased body weight 4 | 161
hypoactivity 4 | 132
decreased body length 3 | 101
decreased neutrophil cell numb... 3 | 42
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased mean corpuscular hem... 3 | 36
thrombocytosis 3 | 27
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal spine curvature 2 | 9
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating serum al... 2 | 82
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
increased total body fat amoun... 2 | 134
long tibia 2 | 25
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
thrombocytopenia 2 | 56
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal heart position or ori... 1 | 1
abnormal hindlimb morphology 1 | 2
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal pelvic girdle bone mo... 1 | 12
abnormal rib morphology 1 | 10
abnormal tail morphology 1 | 25
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
abnormal vocalization 1 | 21
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased basophil cell number 1 | 7
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased hematocrit 1 | 46
increased lymphocyte cell numb... 1 | 32
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
narrow eye opening 1 | 12
prenatal lethality prior to he... 1 | 87
vertebral fusion 1 | 23

Disease

Carcinoma 58 | 11,493
ovarian cancer 47 | 8,520
osteosarcoma 40 | 7,950
medulloblastoma, large-cell 33 | 6,241
glioblastoma 27 | 5,792
atypical teratoid / rhabdoid tumor 26 | 5,112
adult high grade glioma 18 | 3,801
ependymoma 16 | 4,679
lung cancer 16 | 4,740
psoriasis 16 | 6,694
Kidney cancer 14 | 2,613
astrocytic glioma 14 | 2,597
Cancer 12 | 2,499
group 4 medulloblastoma 12 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
juvenile dermatomyositis 12 | 1,187
oligodendroglioma 12 | 2,850
primitive neuroectodermal tumor 12 | 3,035
subependymal giant cell astrocytoma 12 | 2,287
group 3 medulloblastoma 11 | 4,104
malignant mesothelioma 11 | 3,232
Breast cancer 10 | 3,578
diabetes mellitus 10 | 1,728
spina bifida 10 | 1,074
Pick disease 9 | 1,894
lung adenocarcinoma 9 | 2,716
Rheumatoid arthritis 8 | 1,191
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung carcinoma 8 | 2,843
non-small cell lung cancer 8 | 2,890
Astrocytoma, Pilocytic 7 | 3,081
adrenocortical carcinoma 7 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
tuberculosis 7 | 2,010
acute myeloid leukemia 6 | 783
pituitary cancer 6 | 1,972
Atopic dermatitis 5 | 952
Parkinson's disease 5 | 392
dermatomyositis 5 | 966
hereditary spastic paraplegia 5 | 318
invasive ductal carcinoma 5 | 2,951
tuberculosis and treatment for 6 months 5 | 409
Amyotrophic lateral sclerosis 4 | 451
Carcinoma, Hepatocellular 4 | 228
Liver carcinoma 4 | 240
Machado-Joseph disease 4 | 18
Multiple myeloma 4 | 1,332
Waldenstrons macroglobulinemia 4 | 765
aldosterone-producing adenoma 4 | 665
cystic fibrosis 4 | 1,696
interstitial cystitis 4 | 2,312
ulcerative colitis 4 | 1,819
Bipolar Disorder 3 | 666
Blepharoptosis 3 | 231
Crohn's disease 3 | 321
Mental Depression 3 | 333
Schizophrenia 3 | 1,160
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
acute quadriplegic myopathy 3 | 1,158
chronic rhinosinusitis 3 | 512
esophageal adenocarcinoma 3 | 737
medulloblastoma 3 | 720
pancreatic cancer 3 | 2,398
progressive supranuclear palsy 3 | 676
Alzheimer's disease 2 | 658
Asthma 2 | 385
Atrophy of cerebellum 2 | 103
Babinski Reflex 2 | 100
Bladder Neoplasm 2 | 112
Cerebellar degeneration 2 | 103
Cerebral atrophy 2 | 178
Congestive heart failure 2 | 113
Constipation 2 | 181
Degenerative brain disorder 2 | 100
Failure to gain weight 2 | 365
Gaucher disease type 1 2 | 180
Infertility 2 | 188
Infratentorial atrophy 2 | 103
Liver cancer 2 | 604
Lung Neoplasms 2 | 232
Multiple Sclerosis 2 | 540
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Pediatric failure to thrive 2 | 365
Progressive disorder 2 | 142
Supratentorial atrophy 2 | 94
Urinary Bladder Neoplasms 2 | 114
Ventricular Septal Defects 2 | 119
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
gastric cancer 2 | 459
hepatocellular carcinoma 2 | 547
non diabetic and post-ischemic heart failure 2 | 200
pancreatic carcinoma 2 | 562
posterior fossa group B ependymoma 2 | 416
substance-related disorder 2 | 162
tuberculosis and treatment for 3 months 2 | 179

Tissue

Endocrine System 73 | 18,159
Blood and immune system 72 | 16,909
Digestive Tract 72 | 17,369
Female tissues 72 | 17,400
Male tissues 72 | 17,142
Skin and soft tissues 72 | 17,230
Liver and Pancreas 71 | 16,750
Nervous System 71 | 16,725
Respiratory system 71 | 16,393
Urinary Tract 71 | 16,678
Cardiovascular System 69 | 15,192

Target Family

Enzyme 56 | 4,145
Non-IDG 19 | 12,091
Transcription Factor 1 | 1,400

GO Function

thiol-dependent ubiquitin-spec... 76 | 76
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 21 USP21 Tbio Enzyme -1.64460 44.9 288
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
OTU domain-containing protein 4 OTUD4 Tbio Non-IDG -0.45864 3.06 138
Ubiquitin carboxyl-terminal hydrolase 11 USP11 Tbio Enzyme -1.24255 18.0 230
Ubiquitin carboxyl-terminal hydrolase 34 USP34 Tbio Enzyme -0.03779 1.93 72
Ubiquitin carboxyl-terminal hydrolase 30 USP30 Tbio Enzyme -1.23257 18.2 119
Ubiquitin carboxyl-terminal hydrolase 31 USP31 Tbio Enzyme 0.48 0.00000 42
Ubiquitin carboxyl-terminal hydrolase 6 USP6 Tbio Enzyme -1.93358 81.9 169
Ubiquitin carboxyl-terminal hydrolase 5 USP5 Tchem Enzyme -2.22247 166.1 227
Ubiquitin carboxyl-terminal hydrolase 35 USP35 Tbio Enzyme -0.93084 6.23 64