Development Level

Tbio 63 | 10,625
Tchem 9 | 1,890
Tdark 3 | 7,003

IMPC Phenotype

preweaning lethality, complete... 9 | 633
decreased lean body mass 6 | 195
abnormal behavior 5 | 226
decreased body weight 5 | 174
increased circulating alkaline... 5 | 119
decreased neutrophil cell numb... 3 | 37
decreased total body fat amoun... 3 | 186
hyperactivity 3 | 108
increased bone mineral content 3 | 92
increased circulating choleste... 3 | 53
increased sacral vertebrae num... 3 | 62
abnormal bone structure 2 | 131
abnormal gait 2 | 51
decreased B cell number 2 | 30
decreased body length 2 | 108
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
decreased erythrocyte cell num... 2 | 43
decreased gamma-delta T cell n... 2 | 18
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased monocyte cell number 2 | 28
increased CD4-positive, alpha ... 2 | 15
increased NK cell number 2 | 19
increased T cell number 2 | 15
increased alpha-beta T cell nu... 2 | 9
increased circulating HDL chol... 2 | 63
increased granulocyte number 2 | 8
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased monocyte cell number 2 | 27
preweaning lethality, incomple... 2 | 260
thrombocytopenia 2 | 46
thrombocytosis 2 | 23
abnormal bone mineralization 1 | 55
abnormal coat-hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal femur morphology 1 | 14
abnormal heart position or ori... 1 | 1
abnormal hindlimb morphology 1 | 2
abnormal locomotor activation 1 | 26
abnormal rib morphology 1 | 28
abnormal spine curvature 1 | 7
abnormal tail morphology 1 | 17
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
abnormal vocalization 1 | 21
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased effector memory CD4-... 1 | 6
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased immature B cell numb... 1 | 1
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased pre-B cell number 1 | 1
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
increased CD8-positive, alpha-... 1 | 11
increased NK T cell number 1 | 11
increased circulating LDL chol... 1 | 15
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased circulating phosphat... 1 | 24
increased circulating serum al... 1 | 25
increased effector memory CD4-... 1 | 15
increased lean body mass 1 | 107
increased lymphocyte cell numb... 1 | 9
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 25
increased myeloid cell number ... 1 | 1
increased pre-pro B cell numbe... 1 | 2
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 57
narrow eye opening 1 | 15
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
vertebral fusion 1 | 23

Disease

ovarian cancer 48 | 8,491
osteosarcoma 39 | 7,933
medulloblastoma, large-cell 33 | 6,234
glioblastoma 27 | 5,572
atypical teratoid / rhabdoid tumor 24 | 4,369
psoriasis 16 | 6,685
lung cancer 15 | 4,473
adult high grade glioma 14 | 2,148
Carcinoma 12 | 2,147
astrocytic glioma 12 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
juvenile dermatomyositis 12 | 1,189
oligodendroglioma 12 | 2,849
primitive neuroectodermal tumor 12 | 3,031
subependymal giant cell astrocytoma 12 | 2,287
Cancer 11 | 2,346
ependymoma 11 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
medulloblastoma 11 | 1,524
diabetes mellitus 10 | 1,663
malignant mesothelioma 10 | 3,163
spina bifida 10 | 1,064
Breast cancer 9 | 3,098
Pick disease 9 | 1,893
lung adenocarcinoma 9 | 2,714
Rheumatoid Arthritis 8 | 1,170
group 3 medulloblastoma 8 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
lung carcinoma 8 | 2,844
non-small cell lung cancer 7 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
pilocytic astrocytoma 7 | 3,086
tuberculosis and treatment for 6 months 7 | 686
acute myeloid leukemia 6 | 785
adrenocortical carcinoma 6 | 1,427
group 4 medulloblastoma 6 | 1,875
pituitary cancer 6 | 1,972
tuberculosis 6 | 1,563
Atopic dermatitis 5 | 944
Parkinson's disease 5 | 364
dermatomyositis 5 | 966
invasive ductal carcinoma 5 | 2,950
pediatric high grade glioma 5 | 2,712
Amyotrophic Lateral Sclerosis 4 | 432
Liver carcinoma 4 | 217
Machado-Joseph disease 4 | 18
Multiple myeloma 4 | 1,327
Waldenstrons macroglobulinemia 4 | 764
aldosterone-producing adenoma 4 | 664
astrocytoma 4 | 1,493
cystic fibrosis 4 | 1,670
hereditary spastic paraplegia 4 | 313
interstitial cystitis 4 | 2,299
posterior fossa group B ependymoma 4 | 1,530
ulcerative colitis 4 | 2,087
Crohn's disease 3 | 304
active Crohn's disease 3 | 918
acute quadriplegic myopathy 3 | 1,157
chronic rhinosinusitis 3 | 512
esophageal adenocarcinoma 3 | 737
inflammatory breast cancer 3 | 404
non-small cell lung carcinoma 3 | 413
pancreatic cancer 3 | 2,300
posterior fossa group A ependymoma 3 | 1,511
progressive supranuclear palsy 3 | 674
Alzheimer's disease 2 | 644
Congestive heart failure 2 | 36
DiGeorge syndrome 2 | 46
Gaucher disease type 1 2 | 171
Mental depression 2 | 58
Multiple Sclerosis 2 | 498
Muscular atrophy 2 | 67
Neurodegenerative disease 2 | 383
Neuropathy 2 | 210
PARKINSON DISEASE, LATE-ONSET 2 | 20
Thymoma 2 | 16
active ulcerative colitis 2 | 477
atypical teratoid/rhabdoid tumor 2 | 1,095
colon cancer 2 | 1,475
cutaneous lupus erythematosus 2 | 1,056
gastric cancer 2 | 436
hepatocellular carcinoma 2 | 550
non diabetic and post-ischemic heart failure 2 | 200
pancreatic carcinoma 2 | 567
sonic hedgehog group medulloblastoma 2 | 1,482
Aphasia 1 | 22
Blind loop syndrome 1 | 2
Brain Diseases 1 | 22
Celiac disease 1 | 112
Eye and adnexa disease 1 | 11
Gilles de la Tourette syndrome 1 | 47
Juvenile rheumatoid arthritis 1 | 105
Lupus Erythematosus, Systemic 1 | 73
Lymphoma, T-Cell, Cutaneous 1 | 21
Multiple system atrophy 1 | 27
Sertoli cell-only syndrome 1 | 36
Skin disease 1 | 65
Spinocerebellar ataxia type 2 1 | 19
Thrombophlebitis 1 | 16
non-syndromic X-linked intellectual disability 1 | 21

Tissue

Female tissues 75 | 18,646
Male tissues 75 | 17,968
Nervous System 75 | 18,560
Digestive Tract 74 | 18,472
Blood and immune system 73 | 17,994
Cardiovascular System 73 | 17,957
Endocrine System 73 | 18,511
Urinary Tract 73 | 18,443
Liver and Pancreas 72 | 18,135
Skin and soft tissues 72 | 18,114
Respiratory system 69 | 17,483

Target Family

Enzyme 55 | 4,146
Non-IDG 19 | 11,969
Transcription Factor 1 | 1,400

GO Function

thiol-dependent ubiquitin-spec... 75 | 75
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 17 USP17L2 Tbio Enzyme -0.62169 10.9 79
Ubiquitin carboxyl-terminal hydrolase 11 USP11 Tbio Enzyme -1.12593 14.9 210
Ubiquitin carboxyl-terminal hydrolase 28 USP28 Tbio Enzyme -1.38764 22.9 168
OTU domain-containing protein 4 OTUD4 Tbio Non-IDG -0.43270 3.02 114
Ubiquitin carboxyl-terminal hydrolase 19 USP19 Tbio Enzyme -1.23829 20.5 116
Ubl carboxyl-terminal hydrolase 18 USP18 Tbio Enzyme -1.77723 68.2 69
Ubiquitin carboxyl-terminal hydrolase 46 USP46 Tbio Enzyme -1.16869 13.9 72
Ubiquitin carboxyl-terminal hydrolase 47 USP47 Tchem Enzyme -0.67298 5.85 100
Ubiquitin carboxyl-terminal hydrolase CYLD CYLD Tbio Enzyme -2.90259 806.3 176
Ubiquitin carboxyl-terminal hydrolase MINDY-1 FAM63A Tbio Non-IDG 0.00000 0.42 49