Development Level

Tbio 3 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal coat- hair morphology 1 | 19
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
embryonic lethality prior to o... 1 | 239
increased aggression 1 | 4
increased grip strength 1 | 41
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979

Disease

lung cancer 4 | 4,740
Autosomal recessive predisposition 3 | 1,442
Carcinoma 3 | 11,493
Rothmund-Thomson syndrome 3 | 19
Short stature 3 | 531
medulloblastoma, large-cell 3 | 6,241
osteosarcoma 3 | 7,950
ovarian cancer 3 | 8,520
Baller-Gerold syndrome 2 | 12
Bloom syndrome 2 | 29
Breast cancer 2 | 3,578
Cataract 2 | 297
Cryptorchidism 2 | 296
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diarrhea 2 | 253
Fanconi anemia 2 | 56
Fetal Growth Retardation 2 | 189
Hair shaft abnormalities 2 | 30
Hypogonadism 2 | 173
Infant, Small for Gestational Age 2 | 176
Intrauterine retardation 2 | 176
Kidney cancer 2 | 2,613
Lens Opacities 2 | 231
Malignant Squamous Cell Neoplasm 2 | 17
Narrow face 2 | 54
Osteoporosis 2 | 363
Photosensitivity of skin 2 | 51
Premature canities 2 | 24
Rapadilino syndrome 2 | 7
Short nose 2 | 132
Small hand 2 | 36
Small nose 2 | 132
Squamous cell carcinoma 2 | 129
Thin face 2 | 54
Werner syndrome 2 | 29
colon cancer 2 | 1,478
group 3 medulloblastoma 2 | 4,104
hair abnormalities (non-specific) 2 | 30
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
psoriasis 2 | 6,694
Abnormal vertebral bodies 1 | 16
Abnormality of the metacarpal bones 1 | 17
Absent carpal bones 1 | 2
Absent eyebrow 1 | 13
Absent finger 1 | 4
Absent metacarpal(s) 1 | 1
Absent wrist bone 1 | 2
Agenesis of eyebrows 1 | 13
Annular pancreas 1 | 12
Anomalous splenoportal venous system 1 | 1
Anteriorly placed anus 1 | 7
Aphalangy of the hands 1 | 1
Aplasia of eyebrows 1 | 13
Atrophic condition of skin 1 | 25
Bicoronal synostosis 1 | 3
Brachyturricephaly 1 | 4
Brittle hair 1 | 25
Carpal bone anomalies 1 | 5
Cleft uvula 1 | 27
Congenital anomaly of spine 1 | 16
Congenital anomaly of the kidney 1 | 12
Congenital hypoplasia of radius 1 | 23
Craniosynostosis radial aplasia syndrome 1 | 1
Flat forehead 1 | 5
Forearm reduction defects 1 | 2
Fractured hair 1 | 25
Fragile hair 1 | 25
Hypoplasia of thumb 1 | 26
Juvenile zonular cataracts 1 | 1
Limited elbow movement 1 | 6
Limited shoulder movement 1 | 3
Madarosis of eyebrow 1 | 13
Midface capillary hemangioma 1 | 1
Mottled pigmentation 1 | 4
Multiple vertebral anomalies 1 | 16
Nail abnormality 1 | 22
Patellar hypoplasia 1 | 2
Perineal fistula 1 | 1
Poikiloderma 1 | 14
Postnatal growth retardation 1 | 57
Precociously senile appearance 1 | 18
Radial aplasia/hypoplasia 1 | 29
Radial ray hypoplasia 1 | 23
Reduced tensile strength of hair 1 | 25
Rib fusion 1 | 16
Rothmund-Thomson syndrome type 2 1 | 1
Short ulnae 1 | 24
Slender nose 1 | 3
Stiff interphalangeal joints 1 | 1
Stippled pigmentation 1 | 4
Thin hypoplastic alae nasi 1 | 51
Thumb absent or hypoplastic 1 | 9
Thumb aplasia 1 | 16
Tooth hypoplasia 1 | 7
Tooth, Supernumerary 1 | 7
ULNAR HYPOPLASIA 1 | 24
Ulnar bowing 1 | 10

Tissue

Blood and immune system 3 | 16,909
Cardiovascular System 3 | 15,192
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678

Target Family

Enzyme 2 | 4,145
Non-IDG 2 | 12,091

GO Function

telomeric D-loop binding 4 | 4
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
Protection of telomeres protein 1 POT1 Tbio Non-IDG -1.81787 59.9 202
Werner syndrome ATP-dependent helicase WRN Tbio Enzyme -2.73759 569.7 210
Bloom syndrome protein BLM Tchem Non-IDG -2.03028 104.1 314