Development Level

Tbio 36 | 11,445
Tchem 10 | 1,598
Tdark 6 | 6,588

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
decreased grip strength 2 | 116
embryonic lethality prior to o... 2 | 239
impaired glucose tolerance 2 | 75
increased mean corpuscular vol... 2 | 92
abnormal blood vessel morpholo... 1 | 5
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal facial morphology 1 | 17
abnormal heart left ventricle ... 1 | 16
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal snout morphology 1 | 23
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
excessive tearing 1 | 2
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
premature death 1 | 5

Disease

Carcinoma 35 | 11,493
ovarian cancer 33 | 8,520
osteosarcoma 24 | 7,950
medulloblastoma, large-cell 19 | 6,241
lung cancer 16 | 4,740
psoriasis 15 | 6,694
Autosomal recessive predisposition 14 | 1,442
glioblastoma 11 | 5,792
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
Cancer 9 | 2,499
atypical teratoid / rhabdoid tumor 9 | 5,112
group 3 medulloblastoma 9 | 4,104
Breast cancer 7 | 3,578
Intellectual disability 7 | 1,016
Multiple myeloma 7 | 1,332
Neurodegenerative disease 7 | 414
Small head 7 | 374
sonic hedgehog group medulloblastoma 7 | 467
Distal sensory impairment 6 | 52
Epilepsy 6 | 792
Failure to gain weight 6 | 365
Leigh disease 6 | 100
Neuropathy 6 | 261
Pediatric failure to thrive 6 | 365
adult high grade glioma 6 | 3,801
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
juvenile dermatomyositis 6 | 1,187
Anemia 5 | 365
Breast Neoplasms 5 | 445
Charcot-Marie-Tooth disease 5 | 62
Highly variable severity 5 | 157
Kidney cancer 5 | 2,613
Muscle hypotonia 5 | 571
Nystagmus 5 | 317
Variable expressivity 5 | 157
acute quadriplegic myopathy 5 | 1,158
colon cancer 5 | 1,478
dermatomyositis 5 | 966
ependymoma 5 | 4,679
malignant mesothelioma 5 | 3,232
non-small cell lung cancer 5 | 2,890
primitive neuroectodermal tumor 5 | 3,035
Absent reflex 4 | 92
Absent tendon reflex 4 | 92
Cerebral atrophy 4 | 178
Decreased tendon reflex 4 | 122
Fetal Growth Retardation 4 | 189
Foot dorsiflexor weakness 4 | 27
Foot-drop 4 | 27
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Reflex, Deep Tendon, Absent 4 | 92
Short stature 4 | 531
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 783
cystic fibrosis 4 | 1,696
tuberculosis 4 | 2,010
Acidosis, Lactic 3 | 97
Astrocytoma, Pilocytic 3 | 3,081
Axonal neuropathy 3 | 27
Cerebellar Ataxia 3 | 304
Degenerative brain disorder 3 | 100
Distal limb muscle weakness due to peripheral neuropathy 3 | 62
Distal muscle weakness 3 | 62
Dull intelligence 3 | 645
Gait, Drop Foot 3 | 24
Hemoglobin low 3 | 124
Hyperreflexia 3 | 209
Increased serum lactate 3 | 60
Lactic acidemia 3 | 95
Leukodystrophy 3 | 55
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Muscle Spasticity 3 | 195
Myositis 3 | 30
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Peripheral axonal neuropathy 3 | 18
Pick disease 3 | 1,894
Poor school performance 3 | 645
Progressive disorder 3 | 142
Seizures 3 | 596
Slow progression 3 | 89
Supratentorial atrophy 3 | 94
interstitial lung disease 3 | 298
invasive ductal carcinoma 3 | 2,951
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
progressive supranuclear palsy 3 | 676
subependymal giant cell astrocytoma 3 | 2,287
Atrophy of cerebellum 2 | 103
Infratentorial atrophy 2 | 103
Liver Dysfunction 2 | 99
Liver function tests abnormal finding 2 | 81

Tissue

Blood and immune system 52 | 16,909
Digestive Tract 52 | 17,369
Endocrine System 52 | 18,159
Cardiovascular System 51 | 15,192
Female tissues 51 | 17,400
Liver and Pancreas 51 | 16,750
Male tissues 51 | 17,142
Nervous System 51 | 16,725
Respiratory system 51 | 16,393
Skin and soft tissues 51 | 17,230
Urinary Tract 51 | 16,678

Target Family

Enzyme 32 | 4,145
Non-IDG 18 | 12,091
Kinase 2 | 634

GO Function

tRNA binding 52 | 52
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable tRNA(His) guanylyltransferase THG1L Tbio Enzyme -0.60206 3.69 71
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.11190 1198.0 95
Tyrosine--tRNA ligase, cytoplasmic YARS Tchem Enzyme -2.45633 272.6 180
YrdC domain-containing protein, mitochondrial YRDC Tdark Non-IDG -1.79367 58.5 23
O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS Tbio Enzyme -2.11362 120.5 120
Alanine--tRNA ligase, cytoplasmic AARS Tbio Enzyme -2.49617 295.2 140
Cysteine--tRNA ligase, cytoplasmic CARS Tbio Enzyme -3.00492 954.7 154
Exportin-T XPOT Tbio Non-IDG -1.46210 29.6 86
Nucleic acid dioxygenase ALKBH1 ALKBH1 Tbio Enzyme -2.09946 119.6 149
L-seryl-tRNA(Sec) kinase PSTK Tdark Kinase -1.27559 18.1 37