Development Level

Tbio 4 | 11,445

IMPC Phenotype

abnormal snout morphology 1 | 23
decreased circulating amylase ... 1 | 28
decreased mean corpuscular vol... 1 | 79
excessive tearing 1 | 2
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 3 | 11,493
osteosarcoma 3 | 7,950
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
Abnormality of female external genitalia 1 | 8
Abnormality of the antihelix 1 | 10
Acquired metabolic disease 1 | 336
Attention deficit hyperactivity disorder 1 | 278
Autosomal recessive hypophosphatemic rickets 1 | 2
Autosomal recessive predisposition 1 | 1,442
Axial hypotonia 1 | 46
Bilateral fifth finger clinodactyly 1 | 110
Blepharophimosis 1 | 70
Blepharoptosis 1 | 231
Breast Neoplasms 1 | 445
Broad thumbs 1 | 28
Bushy eyebrows 1 | 49
Cognitive delay 1 | 608
Concave bridge of nose 1 | 195
Congenital Epicanthus 1 | 177
Congenital deafness 1 | 185
Curvature of little finger 1 | 110
Deafness 1 | 198
Delayed bone age 1 | 136
Delayed speech and language development 1 | 112
Depressed nasal bridge 1 | 195
Depressed nasal root/bridge 1 | 195
Dirofilariasis 1 | 3
Dubowitz syndrome 1 | 13
Dull intelligence 1 | 645
Dysarthria 1 | 192
Eczema 1 | 45
Fine hair 1 | 42
Global developmental delay 1 | 608
Hearing Loss, Partial 1 | 185
Hyperplasia of nose 1 | 23
Hyperreflexia 1 | 209
Hypertrophy of nose 1 | 23
Hypoplastic feet 1 | 66
Hypoplastic mandible condyle 1 | 275
Intrauterine retardation 1 | 176
Kidney cancer 1 | 2,613
Language Delay 1 | 112
Large nose 1 | 23
Late fontanel closure 1 | 28
Laterally sparse eyebrows 1 | 12
Long face 1 | 71
Low Birth Weights 1 | 69
Low anterior hairline 1 | 30
Low intelligence 1 | 645
Low-set, posteriorly rotated ears 1 | 110
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 5 1 | 1
Mental and motor retardation 1 | 608
Mental deficiency 1 | 645
Microcephaly 1 | 166
Muscle Spasticity 1 | 195
Narrow face 1 | 54
Neoplasm Metastasis 1 | 168
Orbital separation diminished 1 | 23
Penile hypospadias 1 | 106
Poor school performance 1 | 645
Postnatal growth retardation 1 | 57
Prominent ear 1 | 56
Protruding ears 1 | 56
Recurrent infections 1 | 48
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Rheumatoid arthritis 1 | 1,191
Sandal gap 1 | 24
Short lower third of face 1 | 9
Short philtrum 1 | 53
Short stature 1 | 531
Sloping forehead 1 | 46
Small chin 1 | 9
Small for gestational age (disorder) 1 | 69
Small hand 1 | 36
Small head 1 | 374
Smooth philtrum 1 | 43
Sparse scalp hair 1 | 42
Speech Delay 1 | 112
Speech impairment 1 | 112
Strabismus 1 | 270
Submucous cleft of hard palate 1 | 11
Submucous clefting 1 | 9
Synophrys 1 | 40
Telecanthus 1 | 62
Thin face 1 | 54
Thin hypoplastic alae nasi 1 | 51
Thumb absent or hypoplastic 1 | 9
Underdeveloped brows 1 | 38
Underdeveloped supraorbital ridges 1 | 38
Wide anterior fontanel 1 | 44
adult high grade glioma 1 | 3,801
glioblastoma 1 | 5,792
group 3 medulloblastoma 1 | 4,104
hearing impairment 1 | 199
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
ovarian cancer 1 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
progressive supranuclear palsy 1 | 676

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Enzyme 4 | 4,145

GO Function

tRNA (cytosine-5-)-methyltrans... 4 | 4
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
tRNA (cytosine(38)-C(5))-methyltransferase TRDMT1 Tbio Enzyme -1.99628 94.9 337
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial NSUN3 Tbio Enzyme -0.56275 3.91 88
Putative methyltransferase NSUN6 NSUN6 Tbio Enzyme -0.36352 2.94 58
tRNA (cytosine(34)-C(5))-methyltransferase NSUN2 Tbio Enzyme -1.89614 80.1 108