Development Level

Tbio 4 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal bone structure 1 | 187
decreased circulating serum al... 1 | 82
decreased total body fat amoun... 1 | 207
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating potassiu... 1 | 29
short tibia 1 | 97
thrombocytosis 1 | 27

Disease

Autosomal recessive predisposition 4 | 1,442
Carcinoma 4 | 11,493
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Mucopolysaccharidosis 4 | 26
Poor school performance 4 | 645
osteosarcoma 4 | 7,950
Coarse facial features 3 | 108
Congenital deafness 3 | 185
Deafness 3 | 198
Epilepsy 3 | 792
Hearing Loss, Partial 3 | 185
Hepatomegaly 3 | 285
Recurrent upper respiratory tract infection 3 | 21
Seizures 3 | 596
Thickened facial skin with coarse facial features 3 | 108
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
hearing impairment 3 | 199
malignant mesothelioma 3 | 3,232
psoriasis 3 | 6,694
Astrocytoma, Pilocytic 2 | 3,081
Asymmetric Septal Hypertrophy 2 | 7
Cloudy cornea 2 | 33
Coarse hair 2 | 31
Corneal stromal opacities 2 | 33
Diarrhea 2 | 253
Dysarthria 2 | 192
Gangliosidosis 2 | 20
Heparan sulfate excretion in urine 2 | 5
Hirsutism 2 | 47
Hyperactive behavior 2 | 91
Inflammation 2 | 120
Joint stiffness 2 | 84
Macrostomia 2 | 72
Metachromatic leukodystrophy 2 | 14
Mucopolysaccharidosis III 2 | 7
Mucosulfatidosis 2 | 5
Ovoid thoracolumbar vertebrae 2 | 3
Pfaundler-Hurler Syndrome 2 | 12
Rough hair texture 2 | 31
Sleep disturbances 2 | 37
Splenomegaly 2 | 190
Synophrys 2 | 40
Thick rib 2 | 5
abnormal growth 2 | 26
acute quadriplegic myopathy 2 | 1,158
adult high grade glioma 2 | 3,801
glioblastoma 2 | 5,792
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung cancer 2 | 4,740
medulloblastoma, large-cell 2 | 6,241
ovarian cancer 2 | 8,520
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
Attention Deficit Disorder with Hyperactivity 1 | 21
Bushy eyebrows 1 | 49
Congenital ichthyosiform erythroderma 1 | 28
Coxa valga 1 | 22
Coxa valga deformity 1 | 22
Deglutition Disorders 1 | 132
Dense calvaria 1 | 2
Dental caries 1 | 164
Diabetes Mellitus, Experimental 1 | 108
Drooling 1 | 27
Dry skin 1 | 75
Dysphasia 1 | 23
Fatty Liver 1 | 70
Full lower lip 1 | 64
Glomerulonephritis 1 | 46
Heart valve disease 1 | 39
Hyperkeratosis 1 | 50
Hyperkyphosis 1 | 111
Hypertrophy of lower jaw 1 | 78
Ichthyosis vulgaris 1 | 11
Insulin Resistance 1 | 72
Joint laxity 1 | 54
Kluver-Bucy syndrome 1 | 6
Knee joint valgus deformity 1 | 56
Kyphosis deformity of spine 1 | 114
Larsen syndrome 1 | 10
Lordosis 1 | 54
Nephrotic Syndrome 1 | 78
ODONTOID HYPOPLASIA 1 | 16
Platyspondyly 1 | 56
Prominent lower lip 1 | 64
Rotting teeth 1 | 73
Short-trunked dwarfism 1 | 13
Sialorrhea 1 | 28
Spinal cord disease 1 | 25
Spondyloepiphyseal dysplasia with congenital joint dislocations 1 | 13
Weight Gain 1 | 100
Widely spaced teeth 1 | 31
X- linked recessive 1 | 110
Xerosis 1 | 75
pseudo-Hurler polydystrophy 1 | 6

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 5 | 4,145

GO Function

sulfuric ester hydrolase activ... 5 | 5
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Arylsulfatase A ARSA Tbio Enzyme -2.50334 319.0 337
N-acetylglucosamine-6-sulfatase GNS Tbio Enzyme -2.69362 478.4 159
N-acetylgalactosamine-6-sulfatase GALNS Tbio Enzyme -2.43232 272.7 229
N-sulphoglucosamine sulphohydrolase SGSH Tbio Enzyme -2.17271 151.8 156
Steryl-sulfatase STS Tchem Enzyme -2.58736 367.5 212