Development Level

Tbio 143 | 11,445
Tdark 79 | 6,588
Tchem 5 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
improved glucose tolerance 5 | 79
decreased vertical activity 4 | 208
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
decreased fasted circulating g... 3 | 65
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal skin morphology 2 | 50
abnormal tooth morphology 2 | 24
decreased circulating calcium ... 2 | 36
decreased circulating free fat... 2 | 31
decreased circulating insulin ... 2 | 76
decreased erythrocyte cell num... 2 | 62
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
increased fasted circulating g... 2 | 76
increased mean corpuscular hem... 2 | 96
male infertility 2 | 123
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged uterus 1 | 11
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 36
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
shortened PR interval 1 | 6
shortened RR interval 1 | 17
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 118 | 11,493
psoriasis 112 | 6,694
ovarian cancer 86 | 8,520
medulloblastoma, large-cell 62 | 6,241
osteosarcoma 59 | 7,950
atypical teratoid / rhabdoid tumor 58 | 5,112
glioblastoma 50 | 5,792
lung cancer 50 | 4,740
ependymoma 49 | 4,679
Breast cancer 42 | 3,578
non-small cell lung cancer 41 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
pancreatic cancer 39 | 2,398
adult high grade glioma 38 | 3,801
lung adenocarcinoma 36 | 2,716
Kidney cancer 34 | 2,613
diabetes mellitus 34 | 1,728
malignant mesothelioma 34 | 3,232
Atopic dermatitis 32 | 952
Cancer 32 | 2,499
group 3 medulloblastoma 32 | 4,104
Astrocytoma, Pilocytic 31 | 3,081
invasive ductal carcinoma 31 | 2,951
lung carcinoma 31 | 2,843
oligodendroglioma 29 | 2,850
cystic fibrosis 28 | 1,696
interstitial cystitis 28 | 2,312
primitive neuroectodermal tumor 28 | 3,035
subependymal giant cell astrocytoma 25 | 2,287
Autosomal recessive predisposition 24 | 1,442
nasopharyngeal carcinoma 24 | 1,058
primary pancreatic ductal adenocarcinoma 24 | 1,109
breast carcinoma 23 | 1,638
astrocytic glioma 22 | 2,597
ductal carcinoma in situ 21 | 1,745
acute quadriplegic myopathy 20 | 1,158
esophageal adenocarcinoma 20 | 737
pituitary cancer 20 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
colon cancer 18 | 1,478
Multiple myeloma 17 | 1,332
Schizophrenia 16 | 1,160
spina bifida 16 | 1,074
Duchenne muscular dystrophy 15 | 601
group 4 medulloblastoma 15 | 1,855
juvenile dermatomyositis 15 | 1,187
Amyotrophic lateral sclerosis 14 | 451
Liver cancer 13 | 604
Pick disease 13 | 1,894
active Crohn's disease 13 | 922
active ulcerative colitis 12 | 764
adrenocortical carcinoma 12 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 510
dermatomyositis 12 | 966
gastric carcinoma 12 | 807
tuberculosis 12 | 2,010
non primary Sjogren syndrome sicca 11 | 891
pediatric high grade glioma 11 | 1,064
ulcerative colitis 11 | 1,819
Myopia 10 | 176
Alopecia 9 | 115
Hypertensive disease 9 | 292
Hypotrichosis 9 | 47
Mammary Neoplasms 9 | 425
Prostatic Neoplasms 9 | 495
Waldenstrons macroglobulinemia 9 | 765
aldosterone-producing adenoma 9 | 665
fibroadenoma 9 | 559
Breast Neoplasms 8 | 445
Dystrophia unguium 8 | 53
Intellectual disability 8 | 1,016
Muscle hypotonia 8 | 571
astrocytoma 8 | 1,146
cutaneous lupus erythematosus 8 | 1,057
periodontitis 8 | 293
Alzheimer's disease 7 | 658
Atherosclerosis 7 | 291
Dyspnea 7 | 76
Endometriosis 7 | 540
Failure to gain weight 7 | 365
Highly variable severity 7 | 157
Hypertension 7 | 396
Infantile onset 7 | 238
Kidney disease 7 | 430
Melanoma 7 | 711
Nail dysplasia 7 | 52
Nystagmus 7 | 317
Osteoporosis 7 | 363
Pediatric failure to thrive 7 | 365
Rheumatoid arthritis 7 | 1,191
Variable expressivity 7 | 157
posterior fossa group B ependymoma 7 | 416
Anemia 6 | 365
Cerebrovascular disease 6 | 238
Epilepsy 6 | 792
Polycystic ovary syndrome 6 | 360
limb girdle muscular dystrophy 2A 6 | 213
progressive supranuclear palsy 6 | 676

Tissue

Skin and soft tissues 188 | 17,230
Female tissues 185 | 17,400
Digestive Tract 175 | 17,369
Endocrine System 173 | 18,159
Blood and immune system 167 | 16,909
Liver and Pancreas 145 | 16,750
Urinary Tract 145 | 16,678
Male tissues 143 | 17,142
Respiratory system 139 | 16,393
Nervous System 138 | 16,725
Cardiovascular System 123 | 15,192

Target Family

Non-IDG 220 | 12,091
Enzyme 8 | 4,145
Kinase 1 | 634

GO Function

structural molecule activity 229 | 229
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear mitotic apparatus protein 1 NUMA1 Tbio Non-IDG -2.76544 575.8 235
MAP7 domain-containing protein 1 MAP7D1 Tdark Non-IDG 0.27 0.84 52
Keratin, type II cytoskeletal 79 KRT79 Tdark Non-IDG -0.60592 4.17 87
Claudin-16 CLDN16 Tbio Non-IDG -1.98248 102.4 138
Endogenous retrovirus group K member 13-1 Env polyprotein ERVK13-1 Tdark Non-IDG 0.00000 0
Iron-sulfur cluster assembly 1 homolog, mitochondrial ISCA1 Tbio Non-IDG -1.68100 45.7 44
Keratin, type II cytoskeletal 73 KRT73 Tdark Non-IDG 0.20 0.40 87
Endogenous retrovirus group K member 5 Gag polyprotein ERVK-5 Tdark Non-IDG 0.00000 0
Clathrin heavy chain 2 CLTCL1 Tbio Non-IDG -1.29555 21.3 39
Endogenous retrovirus group K member 9 Env polyprotein ERVK-9 Tdark Non-IDG 0.00000 0