Development Level

Tbio 101 | 11,445
Tdark 58 | 6,588
Tchem 1 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 5 | 278
embryonic growth retardation 3 | 106
abnormal embryo size 2 | 220
decreased circulating glucose ... 2 | 126
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal lens morphology 1 | 81
abnormal tail morphology 1 | 25
impaired pupillary reflex 1 | 26
increased circulating creatini... 1 | 38
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38

Disease

ovarian cancer 76 | 8,520
lung cancer 49 | 4,740
Multiple myeloma 37 | 1,332
osteosarcoma 36 | 7,950
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
medulloblastoma, large-cell 29 | 6,241
diabetes mellitus 27 | 1,728
Diamond-Blackfan anemia 25 | 31
psoriasis 23 | 6,694
Breast cancer 22 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Carcinoma 20 | 11,493
atypical teratoid / rhabdoid tumor 20 | 5,112
glioblastoma 19 | 5,792
acute myeloid leukemia 18 | 783
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
Waldenstrons macroglobulinemia 16 | 765
group 3 medulloblastoma 15 | 4,104
malignant mesothelioma 14 | 3,232
non primary Sjogren syndrome sicca 14 | 891
non-small cell lung cancer 14 | 2,890
Abnormality of the urinary system 13 | 21
Anemia 13 | 365
Anemia, Diamond-Blackfan 13 | 16
Anemia, Macrocytic 13 | 18
Breast Neoplasms 13 | 445
Cardiac Arrhythmia 13 | 103
Cardiac conduction abnormalities 13 | 78
Cleft Palate 13 | 271
Conduction disorder of the heart 13 | 79
Delayed Puberty 13 | 97
EKG abnormalities 13 | 78
Electrocardiogram abnormal 13 | 81
Electrocardiogram change 13 | 78
Fatigue 13 | 182
Hand deformities 13 | 32
Intermittent migraine headaches 13 | 68
Mammary Neoplasms 13 | 425
Migraine Disorders 13 | 76
Pallor 13 | 40
Uranostaphyloschisis 13 | 167
genital abnormal 13 | 17
reproductive system abnormality 13 | 17
acute quadriplegic myopathy 12 | 1,158
cystic fibrosis 12 | 1,696
Disease Progression 11 | 136
Stomach Neoplasms 11 | 300
colon cancer 11 | 1,478
sonic hedgehog group medulloblastoma 11 | 467
adult high grade glioma 10 | 3,801
invasive ductal carcinoma 10 | 2,951
lung adenocarcinoma 10 | 2,716
oligodendroglioma 10 | 2,850
astrocytic glioma 9 | 2,597
subependymal giant cell astrocytoma 9 | 2,287
ependymoma 8 | 4,679
Adenocarcinoma of lung 7 | 142
Disease Models, Animal 7 | 155
pediatric high grade glioma 7 | 1,064
astrocytoma 6 | 1,146
mucosa-associated lymphoid tissue lymphoma 6 | 484
primitive neuroectodermal tumor 6 | 3,035
Astrocytoma, Pilocytic 5 | 3,081
Reticulocytopenia 5 | 10
breast carcinoma 5 | 1,638
group 4 medulloblastoma 5 | 1,855
lung carcinoma 5 | 2,843
Brain glioma 4 | 7
Cancer 4 | 2,499
Infantile onset 4 | 238
Parkinson Disease 4 | 64
Pick disease 4 | 1,894
inflammatory breast cancer 4 | 286
Acquired metabolic disease 3 | 336
Animal Mammary Neoplasms 3 | 136
Autosomal recessive predisposition 3 | 1,442
Cardiovascular system disease 3 | 246
Cognitive delay 3 | 608
Duchenne muscular dystrophy 3 | 601
Hereditary spherocytosis type 4 3 | 18
Mammary Neoplasms, Animal 3 | 136
Mammary Neoplasms, Experimental 3 | 154
Mean cell volume increased 3 | 5
Mental and motor retardation 3 | 608
Osteoporosis 3 | 363
Polycystic ovary syndrome 3 | 360
Prostatic Neoplasms 3 | 495
Retinitis pigmentosa 49 3 | 14
Rheumatoid arthritis 3 | 1,191
Shwachman-Diamond syndrome 3 | 17
Ventricular Septal Defects 3 | 119
Weight Gain 3 | 100
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
hereditary spastic paraplegia 3 | 318
nasopharyngeal carcinoma 3 | 1,058
posterior fossa group A ependymoma 3 | 468
primary pancreatic ductal adenocarcinoma 3 | 1,109
ulcerative colitis 3 | 1,819

Tissue

Endocrine System 155 | 18,159
Blood and immune system 154 | 16,909
Digestive Tract 154 | 17,369
Male tissues 154 | 17,142
Skin and soft tissues 154 | 17,230
Cardiovascular System 153 | 15,192
Female tissues 153 | 17,400
Liver and Pancreas 153 | 16,750
Nervous System 153 | 16,725
Respiratory system 153 | 16,393
Urinary Tract 153 | 16,678

Target Family

Non-IDG 159 | 12,091
Enzyme 2 | 4,145

GO Function

structural constituent of ribo... 161 | 161
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
40S ribosomal protein SA RPSA Tbio Non-IDG -2.99323 982.0 230
60S ribosomal protein L34 RPL34 Tbio Non-IDG -2.88138 739.0 112
28S ribosomal protein S7, mitochondrial MRPS7 Tbio Non-IDG -2.78888 576.0 71
40S ribosomal protein S6 RPS6 Tbio Non-IDG -2.76789 501.6 920
39S ribosomal protein L49, mitochondrial MRPL49 Tbio Non-IDG -2.76367 555.1 76
40S ribosomal protein S13 RPS13 Tbio Non-IDG -2.64352 393.6 169
60S ribosomal protein L24 RPL24 Tdark Non-IDG -2.58284 366.9 46
28S ribosomal protein S22, mitochondrial MRPS22 Tbio Non-IDG -2.42971 211.9 107
40S ribosomal protein S16 RPS16 Tbio Non-IDG -2.37710 172.7 157