Development Level

Tbio 130 | 10,625
Tdark 78 | 7,003
Tchem 3 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 4 | 187
decreased body weight 2 | 174
decreased circulating chloride... 2 | 32
decreased circulating glucose ... 2 | 121
decreased total body fat amoun... 2 | 186
embryonic growth retardation 2 | 28
abnormal allantois morphology 1 | 3
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal incisor morphology 1 | 3
abnormal joint morphology 1 | 14
abnormal limb bud morphology 1 | 15
abnormal mandible morphology 1 | 2
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal snout morphology 1 | 18
abnormal tail bud morphology 1 | 6
abnormal tooth morphology 1 | 24
abnormal vertebral arch morpho... 1 | 9
absent pinna reflex 1 | 21
decreased CD11b-low dendritic ... 1 | 3
decreased NK T cell number 1 | 28
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating creatini... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased follicular B cell nu... 1 | 4
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased red blood cell distr... 1 | 11
decreased rib number 1 | 59
enlarged heart 1 | 111
improved glucose tolerance 1 | 56
increased CD11b-high dendritic... 1 | 5
increased KLRG1-positive NK ce... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating creatini... 1 | 29
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased marginal zone B cell... 1 | 3
increased mean corpuscular hem... 1 | 93
increased monocyte cell number 1 | 27
increased red blood cell distr... 1 | 21
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 93 | 8,484
lung cancer 57 | 4,466
osteosarcoma 57 | 7,933
medulloblastoma, large-cell 51 | 6,234
Multiple myeloma 41 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,289
glioblastoma 37 | 5,572
pancreatic ductal adenocarcinoma liver metastasis 35 | 1,795
atypical teratoid / rhabdoid tumor 34 | 4,369
psoriasis 34 | 6,685
diabetes mellitus 32 | 1,663
Breast cancer 27 | 3,094
Diamond-Blackfan anemia 23 | 28
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
sonic hedgehog group medulloblastoma 21 | 1,482
acute myeloid leukemia 20 | 780
malignant mesothelioma 20 | 3,162
primitive neuroectodermal tumor 20 | 3,031
Waldenstrons macroglobulinemia 19 | 765
non-small cell lung cancer 19 | 2,798
adult high grade glioma 18 | 2,148
astrocytic glioma 18 | 2,241
non primary Sjogren syndrome sicca 18 | 840
acute quadriplegic myopathy 17 | 1,157
ependymoma 17 | 2,514
pediatric high grade glioma 17 | 2,712
oligodendroglioma 16 | 2,849
subependymal giant cell astrocytoma 16 | 2,287
cystic fibrosis 15 | 1,665
lung adenocarcinoma 15 | 2,713
medulloblastoma 15 | 1,524
invasive ductal carcinoma 14 | 2,950
pilocytic astrocytoma 14 | 3,086
Anemia, Diamond-Blackfan 13 | 15
Mammary Neoplasms 13 | 410
Pick disease 12 | 1,893
colon cancer 12 | 1,475
lung carcinoma 12 | 2,844
Disease Progression 11 | 125
Stomach Neoplasms 11 | 282
group 3 medulloblastoma 11 | 2,254
Rheumatoid Arthritis 10 | 1,160
astrocytoma 10 | 1,493
breast carcinoma 10 | 1,614
Anemia 9 | 252
posterior fossa group A ependymoma 9 | 1,511
Duchenne muscular dystrophy 8 | 602
adrenocortical carcinoma 8 | 1,427
inflammatory breast cancer 8 | 404
ulcerative colitis 8 | 2,087
atypical teratoid/rhabdoid tumor 7 | 1,095
mucosa-associated lymphoid tissue lymphoma 7 | 480
group 4 medulloblastoma 6 | 1,875
juvenile dermatomyositis 6 | 1,189
Animal Mammary Neoplasms 5 | 136
Cancer 5 | 2,346
Mammary Neoplasms, Experimental 5 | 150
Obesity 5 | 616
dermatomyositis 5 | 933
pancreatic cancer 5 | 2,300
posterior fossa group B ependymoma 5 | 1,530
Brain glioma 4 | 10
Parkinson Disease 4 | 102
Prostatic Neoplasms 4 | 471
cutaneous lupus erythematosus 4 | 1,056
glioblastoma multiforme 4 | 347
hereditary spastic paraplegia 4 | 313
limb girdle muscular dystrophy 2A 4 | 156
nasopharyngeal carcinoma 4 | 1,056
primary pancreatic ductal adenocarcinoma 4 | 1,271
tuberculosis 4 | 1,557
Becker muscular dystrophy 3 | 187
IGA Glomerulonephritis 3 | 454
Irregular astigmatism 3 | 11
Lacrimal gland carcinoma 3 | 5
Melanoma 3 | 261
Metabolic syndrome X 3 | 155
Multiple Sclerosis 3 | 498
Ornithine translocase deficiency 3 | 5
Osteoporosis 3 | 257
Polycystic Ovary Syndrome 3 | 332
Pure red-cell aplasia 3 | 4
Weight Gain 3 | 87
active Crohn's disease 3 | 918
ductal carcinoma in situ 3 | 1,745
esophageal adenocarcinoma 3 | 737
gastric cancer 3 | 430
hepatocellular carcinoma 3 | 532
non diabetic and post-ischemic heart failure 3 | 200
non-inflammatory breast cancer 3 | 208
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 674
Amyotrophic Lateral Sclerosis 2 | 431
Cerebrovascular disease 2 | 231
Down syndrome 2 | 548
Heart disease 2 | 279
aldosterone-producing adenoma 2 | 664
spina bifida 2 | 1,064
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 206 | 17,995
Male tissues 206 | 17,969
Cardiovascular System 205 | 17,958
Digestive Tract 205 | 18,473
Endocrine System 205 | 18,512
Female tissues 205 | 18,647
Liver and Pancreas 205 | 18,136
Nervous System 205 | 18,561
Respiratory system 205 | 17,484
Urinary Tract 205 | 18,444
Skin and soft tissues 203 | 18,115

Target Family

Non-IDG 163 | 11,971
Transporter 47 | 473
Enzyme 2 | 4,146

GO Function

structural constituent of ribo... 212 | 212
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
39S ribosomal protein L37, mitochondrial MRPL37 Tdark Non-IDG -0.30103 2.00 47
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
60S ribosomal protein L18 RPL18 Tbio Non-IDG -1.73537 50.7 134
39S ribosomal protein L19, mitochondrial MRPL19 Tbio Non-IDG -0.91149 8.14 108
60S ribosomal protein L38 RPL38 Tdark Non-IDG -1.39563 24.2 45
Mitochondrial brown fat uncoupling protein 1 UCP1 Tbio Non-IDG -3.04555 1148.0 252
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150