Development Level

Tbio 41 | 11,445
Tdark 5 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal heart morphology 1 | 162
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal vocalization 1 | 21
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased grip strength 1 | 116
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
hypoactivity 1 | 132
increased circulating chloride... 1 | 41
increased heart rate 1 | 23
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened ST segment 1 | 10
thrombocytosis 1 | 27

Disease

Carcinoma 34 | 11,493
psoriasis 20 | 6,694
Breast cancer 18 | 3,578
ovarian cancer 18 | 8,520
atypical teratoid / rhabdoid tumor 17 | 5,112
glioblastoma 17 | 5,792
medulloblastoma, large-cell 17 | 6,241
acute quadriplegic myopathy 16 | 1,158
lung cancer 16 | 4,740
lung adenocarcinoma 15 | 2,716
Myopathy 14 | 185
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Cardiomyopathy 13 | 116
invasive ductal carcinoma 13 | 2,951
pancreatic cancer 13 | 2,398
Autosomal recessive predisposition 12 | 1,442
Kidney cancer 12 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
osteosarcoma 12 | 7,950
Dilated cardiomyopathy 11 | 56
Hypertrophic Cardiomyopathy 11 | 117
breast carcinoma 11 | 1,638
colon cancer 11 | 1,478
Duchenne muscular dystrophy 10 | 601
ependymoma 10 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Cardiomyopathy, Dilated 9 | 83
group 3 medulloblastoma 9 | 4,104
group 4 medulloblastoma 9 | 1,855
lung carcinoma 9 | 2,843
malignant mesothelioma 9 | 3,232
non-small cell lung cancer 9 | 2,890
primitive neuroectodermal tumor 9 | 3,035
Familial isolated dilated cardiomyopathy 8 | 41
LEFT VENTRICULAR NONCOMPACTION 10 8 | 40
LEFT VENTRICULAR NONCOMPACTION 8 8 | 40
Muscular dystrophy 8 | 75
ductal carcinoma in situ 8 | 1,745
Creatine phosphokinase serum increased 7 | 110
Distal arthrogryposis 7 | 42
Elevated creatine kinase 7 | 110
Muscle biopsy shows dystrophic changes 7 | 39
Skin cancer 7 | 469
adrenocortical carcinoma 7 | 1,428
adult high grade glioma 7 | 3,801
limb-girdle muscular dystrophy 7 | 37
subependymal giant cell astrocytoma 7 | 2,287
Astrocytoma, Pilocytic 6 | 3,081
Becker muscular dystrophy 6 | 191
Deglutition Disorders 6 | 132
Liver cancer 6 | 604
oligodendroglioma 6 | 2,850
Acquired scoliosis 5 | 281
Amyotrophic lateral sclerosis 5 | 451
Arthrogryposis 5 | 54
Cancer 5 | 2,499
Contracture 5 | 96
Contracture of joint 5 | 93
Curvature of spine 5 | 282
Flexion contracture 5 | 93
Flexion contractures of joints 5 | 93
Generalized muscle weakness 5 | 57
Liver Cirrhosis, Experimental 5 | 769
Melanoma 5 | 711
Motor delay 5 | 147
Muscle hypotonia 5 | 571
No development of motor milestones 5 | 147
Primary cutaneous amyloidosis 5 | 29
Proximal muscle weakness 5 | 47
Proximal neurogenic muscle weakness 5 | 47
active Crohn's disease 5 | 922
astrocytic glioma 5 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
juvenile dermatomyositis 5 | 1,187
limb girdle muscular dystrophy 2A 5 | 213
Bell Palsy 4 | 58
Blepharoptosis 4 | 231
Decreased tendon reflex 4 | 122
Difficulty walking 4 | 28
Endometrial cancer 4 | 311
Facial Paresis 4 | 59
Facial muscle weakness of muscles innervated by CN VII 4 | 58
Feeding difficulties 4 | 127
Gowers sign 4 | 24
Gowers sign present 4 | 24
Highly variable severity 4 | 157
Lumbar lordosis 4 | 35
Pick disease 4 | 1,894
Prenatal onset 4 | 139
Short stature 4 | 531
Variable expressivity 4 | 157
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
non diabetic and post-ischemic heart failure 4 | 200
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Digestive Tract 46 | 17,369
Endocrine System 46 | 18,159
Urinary Tract 46 | 16,678
Male tissues 45 | 17,142
Skin and soft tissues 45 | 17,230
Blood and immune system 44 | 16,909
Nervous System 44 | 16,725
Female tissues 43 | 17,400
Liver and Pancreas 42 | 16,750
Cardiovascular System 41 | 15,192
Respiratory system 38 | 16,393

Target Family

Non-IDG 42 | 12,091
Enzyme 2 | 4,145
Kinase 2 | 634

GO Function

structural constituent of musc... 46 | 46
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
Immunoglobulin superfamily member 22 IGSF22 Tdark Non-IDG 0.48 0.33 16
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Junctophilin-1 JPH1 Tbio Non-IDG -1.77250 56.2 92
Myomesin-1 MYOM1 Tbio Non-IDG -1.21420 16.8 127
Sorbin and SH3 domain-containing protein 2 SORBS2 Tbio Non-IDG -1.48653 35.6 82
Synemin SYNM Tbio Non-IDG -1.91854 92.6 68
Cysteine and glycine-rich protein 3 CSRP3 Tbio Non-IDG -2.00418 105.2 236
Smoothelin SMTN Tbio Non-IDG -2.07575 114.0 108
Titin TTN Tbio Kinase -3.24415 1743.0 123