Development Level

Tbio 9 | 11,445
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal kidney morphology 1 | 65
abnormal vibrissa morphology 1 | 25
hyperactivity 1 | 148

Disease

psoriasis 10 | 6,694
Carcinoma 6 | 11,493
Congenital ichthyosiform erythroderma 5 | 28
Epidermolytic hyperkeratosis 5 | 14
Palmoplantar keratosis 5 | 74
periodontitis 5 | 293
Carcinoma, Squamous Cell 4 | 110
Contact Dermatitis 4 | 81
Dermatitis, Contact 4 | 71
Erythema 4 | 58
Flushing 4 | 60
Squamous cell carcinoma 4 | 129
esophageal adenocarcinoma 4 | 737
ovarian cancer 4 | 8,520
Atopic dermatitis 3 | 952
Breast cancer 3 | 3,578
Cancer 3 | 2,499
Hyperkeratosis, Epidermolytic 3 | 7
Ichthyosis 3 | 56
Ichthyosis vulgaris 3 | 11
Kidney cancer 3 | 2,613
Skin Neoplasms 3 | 69
Skin disease 3 | 66
osteosarcoma 3 | 7,950
Abnormal blistering of the skin 2 | 54
Blister of skin 2 | 54
Bullous ichthyosiform erythroderma 2 | 4
Congenital reticular ichthyosiform erythroderma 2 | 2
Eczema 2 | 45
Exfoliative dermatitis 2 | 24
Ichthyoses 2 | 41
Ichthyosis, Cyclic, with Epidermolytic Hyperkeratosis 2 | 2
Keratosis 2 | 37
Monilethrix 2 | 18
Nail Diseases 2 | 24
Nail abnormality 2 | 22
Pachyonychia congenita 2 | 10
Papilloma 2 | 44
Peeling of skin 2 | 8
Skin bulla 2 | 54
X-linked ichthyosis 2 | 18
adult high grade glioma 2 | 3,801
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
lung cancer 2 | 4,740
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
Abnormality of the fingernails 1 | 51
Absent eyelashes 1 | 16
Acanthoma 1 | 4
Ainhum 1 | 4
Aplasia of eyelashes 1 | 16
Autosomal recessive congenital ichthyosis 4B 1 | 13
Blepharitis 1 | 23
Cellulitis of eyelid 1 | 17
Chronic diarrhea 1 | 29
Congenital Nonbullous Ichthyosiform Erythroderma 1 | 16
Cutaneous plaque 1 | 5
Dry skin 1 | 75
Ectodermal Dysplasia 1 | 14
Ectodermal Dysplasia-Skin Fragility Syndrome 1 | 1
Ectodermal dysplasia/ skin fragility syndrome 1 | 1
Eczema herpeticum 1 | 7
Elevated IgE 1 | 10
Eosinophilic esophagitis 1 | 16
Epidermolysis bullosa simplex due to plakophilin deficiency 1 | 1
Erythrokeratodermia variabilis 1 | 10
Eyebrow abnormalities 1 | 12
Failure of development of eyelashes 1 | 16
Filamentary keratitis 1 | 5
Fissured tongue 1 | 25
Fragile skin 1 | 18
Hair shaft abnormalities 1 | 30
Hyperhidrosis disorder 1 | 81
Hyperkeratosis 1 | 50
Hypertrichosis 1 | 46
Ichthyosis bullosa of Siemens 1 | 5
Immunologic Deficiency Syndromes 1 | 113
Increased sweating 1 | 81
Keratoderma, Palmoplantar, Diffuse 1 | 4
Leptospirosis 1 | 18
Lichen planus 1 | 16
Molluscum contagiosum 1 | 8
Oculodentodigital dysplasia 1 | 14
Orthokeratosis 1 | 2
Panic disorder 1 | 61
Parakeratosis 1 | 7
Pasteurellosis 1 | 12
Pruritus 1 | 58
Recurrent skin infections 1 | 21
Skin Ulcer 1 | 48
Skin Vesicle 1 | 5
Sweating 1 | 81
Warts 1 | 10
Xerosis 1 | 75
alcohol sensitivity 1 | 3
hair abnormalities (non-specific) 1 | 30
inflammatory breast cancer 1 | 286

Tissue

Female tissues 13 | 17,400
Skin and soft tissues 12 | 17,230
Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Urinary Tract 8 | 16,678
Nervous System 7 | 16,725
Cardiovascular System 6 | 15,192
Respiratory system 4 | 16,393

Target Family

Non-IDG 14 | 12,091

GO Function

structural constituent of epid... 14 | 14
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Plakophilin-1 PKP1 Tbio Non-IDG -1.86062 76.3 103
Keratin, type I cuticular Ha6 KRT36 Tdark Non-IDG -0.31585 2.22 89
Cornifin-A SPRR1A Tbio Non-IDG -1.22598 14.1 80
Keratin-associated protein 1-3 KRTAP1-3 Tdark Non-IDG 0.18 0.78 53
Keratin, type II cytoskeletal 2 epidermal KRT2 Tbio Non-IDG -1.64971 43.0 144
Small proline-rich protein 2E SPRR2E Tbio Non-IDG 0.77 0.10 1
Keratin, type I cytoskeletal 10 KRT10 Tbio Non-IDG -2.84299 654.9 785
Loricrin LOR Tbio Non-IDG -2.58018 365.6 49
Keratin-associated protein 5-8 KRTAP5-8 Tdark Non-IDG 0.00000 1
Keratin, type II cuticular Hb4 KRT84 Tdark Non-IDG -0.14981 1.67 48