Development Level

Tbio 83 | 11,445
Tclin 9 | 613
Tdark 9 | 6,588
Tchem 6 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
preweaning lethality, complete... 4 | 979
decreased body weight 3 | 161
decreased grip strength 3 | 116
decreased vertical activity 3 | 208
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
embryonic lethality prior to t... 2 | 278
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
cataract 1 | 92
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating creatine... 1 | 4
decreased circulating free fat... 1 | 31
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
enlarged uterus 1 | 11
fusion of vertebral arches 1 | 7
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood uric acid leve... 1 | 5
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased granulocyte number 1 | 1
increased heart rate 1 | 23
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
male infertility 1 | 123
narrow eye opening 1 | 12
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prolonged PR interval 1 | 15
short tibia 1 | 97
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened ST segment 1 | 10
small kidney 1 | 16
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

Carcinoma 86 | 11,493
ovarian cancer 52 | 8,520
psoriasis 49 | 6,694
glioblastoma 44 | 5,792
osteosarcoma 43 | 7,950
atypical teratoid / rhabdoid tumor 40 | 5,112
Breast cancer 38 | 3,578
pancreatic cancer 37 | 2,398
ependymoma 36 | 4,679
medulloblastoma, large-cell 36 | 6,241
non-small cell lung cancer 35 | 2,890
group 3 medulloblastoma 32 | 4,104
adult high grade glioma 31 | 3,801
Astrocytoma, Pilocytic 30 | 3,081
lung cancer 29 | 4,740
malignant mesothelioma 28 | 3,232
Kidney cancer 27 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
oligodendroglioma 27 | 2,850
breast carcinoma 26 | 1,638
lung adenocarcinoma 26 | 2,716
primitive neuroectodermal tumor 26 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
invasive ductal carcinoma 22 | 2,951
lung carcinoma 22 | 2,843
astrocytic glioma 21 | 2,597
ductal carcinoma in situ 21 | 1,745
colon cancer 20 | 1,478
subependymal giant cell astrocytoma 20 | 2,287
Pick disease 19 | 1,894
primary pancreatic ductal adenocarcinoma 19 | 1,109
Cancer 18 | 2,499
Duchenne muscular dystrophy 18 | 601
cystic fibrosis 18 | 1,696
interstitial cystitis 16 | 2,312
juvenile dermatomyositis 16 | 1,187
spina bifida 16 | 1,074
pituitary cancer 15 | 1,972
Autosomal recessive predisposition 14 | 1,442
nasopharyngeal carcinoma 14 | 1,058
ulcerative colitis 14 | 1,819
Down syndrome 13 | 499
acute quadriplegic myopathy 13 | 1,158
esophageal adenocarcinoma 13 | 737
Amyotrophic lateral sclerosis 12 | 451
adrenocortical carcinoma 12 | 1,428
cutaneous lupus erythematosus 12 | 1,057
dermatomyositis 12 | 966
group 4 medulloblastoma 12 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Waldenstrons macroglobulinemia 11 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
Atopic dermatitis 10 | 952
Intellectual disability 10 | 1,016
Liposarcoma 10 | 20
Liver Cirrhosis, Experimental 10 | 769
Malignant tumor of prostate 10 | 26
Palmoplantar keratosis 10 | 74
astrocytoma 10 | 1,146
Acute lymphoid leukemia 9 | 25
Alzheimer's disease 9 | 658
Anaplastic large T-cell systemic malignant lymphoma 9 | 10
Burkitt's lymphoma 9 | 15
Carcinoma of breast 9 | 11
Carcinoma of female breast 9 | 20
Cognitive delay 9 | 608
Diffuse non-Hodgkin's lymphoma, large cell 9 | 12
Follicular non-Hodgkin's lymphoma 9 | 17
Gestational trophoblastic neoplasia 9 | 14
Global developmental delay 9 | 608
HER2-positive carcinoma of breast 9 | 21
Hodgkin's disease 9 | 18
Hypertensive disorder 9 | 56
Kaposi's sarcoma 9 | 22
Langerhans cell histiocytosis, disseminated 9 | 10
Malignant tumor of head and/or neck 9 | 15
Malignant tumor of ovary 9 | 25
Malignant tumor of stomach 9 | 12
Malignant tumor of testis 9 | 11
Melanoma 9 | 711
Mental and motor retardation 9 | 608
Metastatic Breast Carcinoma 9 | 21
Metastatic Prostate Carcinoma 9 | 18
Multiple myeloma 9 | 1,332
Mycosis fungoides 9 | 29
Nephroblastoma 9 | 51
Neuroblastoma 9 | 80
Non-Hodgkin's lymphoma 9 | 22
Ocular hypertension 9 | 42
Open-angle glaucoma 9 | 27
Rhabdomyosarcoma 9 | 39
Secondary malignant neoplasm of pancreas 9 | 10
Skin cancer 9 | 469
active ulcerative colitis 9 | 764
aldosterone-producing adenoma 9 | 665
diabetes mellitus 9 | 1,728
transitional cell carcinoma 9 | 22
tuberculosis 9 | 2,010
Rheumatoid arthritis 8 | 1,191

Tissue

Endocrine System 103 | 18,159
Female tissues 100 | 17,400
Skin and soft tissues 100 | 17,230
Blood and immune system 99 | 16,909
Digestive Tract 98 | 17,369
Male tissues 98 | 17,142
Nervous System 94 | 16,725
Urinary Tract 93 | 16,678
Liver and Pancreas 92 | 16,750
Respiratory system 87 | 16,393
Cardiovascular System 83 | 15,192

Target Family

Non-IDG 105 | 12,091
Enzyme 2 | 4,145

GO Function

structural constituent of cyto... 107 | 107
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tubulin alpha-8 chain TUBA8 Tbio Non-IDG -0.87821 7.61 118
Tubulin beta-6 chain TUBB6 Tclin Non-IDG -0.94163 8.01 85
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Actin-like protein 7A ACTL7A Tbio Non-IDG -0.80556 6.32 125
Actin-like protein 7B ACTL7B Tbio Non-IDG -1.01072 10.7 211
Tubulin delta chain TUBD1 Tbio Non-IDG -1.28681 18.5 57
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Talin-2 TLN2 Tbio Non-IDG -1.36153 20.0 101
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Desmin DES Tbio Non-IDG -1.56068 36.6 991