Development Level

Tchem 18 | 1,598
Tbio 17 | 11,445
Tclin 16 | 613
Tdark 2 | 6,588

IMPC Phenotype

abnormal bone structure 3 | 187
increased bone mineral content 3 | 108
increased startle reflex 3 | 112
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
thin ventricular wall 2 | 24
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart looping 1 | 5
abnormal hindbrain development 1 | 16
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal pupil morphology 1 | 2
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal visceral yolk sac mor... 1 | 6
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased cardiac output 1 | 3
decreased circulating alkaline... 1 | 46
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating creatini... 1 | 38
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
pale yolk sac 1 | 25
prolonged QRS complex duration 1 | 8
tremors 1 | 39

Disease

Carcinoma 42 | 11,493
psoriasis 30 | 6,694
osteosarcoma 29 | 7,950
ovarian cancer 24 | 8,520
Cancer 23 | 2,499
medulloblastoma, large-cell 22 | 6,241
glioblastoma 19 | 5,792
lung cancer 19 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
malignant mesothelioma 17 | 3,232
interstitial cystitis 16 | 2,312
adult high grade glioma 15 | 3,801
atypical teratoid / rhabdoid tumor 15 | 5,112
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
invasive ductal carcinoma 15 | 2,951
Breast cancer 14 | 3,578
Endometriosis 14 | 540
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
primitive neuroectodermal tumor 14 | 3,035
ductal carcinoma in situ 13 | 1,745
pituitary cancer 13 | 1,972
ulcerative colitis 13 | 1,819
Obesity 12 | 678
lung adenocarcinoma 12 | 2,716
pancreatic cancer 12 | 2,398
Astrocytoma, Pilocytic 11 | 3,081
Bipolar Disorder 11 | 666
breast carcinoma 11 | 1,638
ependymoma 11 | 4,679
group 4 medulloblastoma 11 | 1,855
lung carcinoma 11 | 2,843
Acne vulgaris 10 | 14
Autosomal recessive predisposition 10 | 1,442
Breast Neoplasms 10 | 445
Mammary Neoplasms 10 | 425
diabetes mellitus 10 | 1,728
Schizophrenia 9 | 1,160
adrenocortical carcinoma 9 | 1,428
cystic fibrosis 9 | 1,696
oligodendroglioma 9 | 2,850
Kaposi's Sarcoma Skin Lesions 8 | 8
astrocytic glioma 8 | 2,597
colon cancer 8 | 1,478
non-small cell lung cancer 8 | 2,890
subependymal giant cell astrocytoma 8 | 2,287
Osteoporosis 7 | 363
tuberculosis 7 | 2,010
Acquired metabolic disease 6 | 336
Adenocarcinoma 6 | 122
Adenoma 6 | 167
Atopic dermatitis 6 | 952
Atrophic vaginitis 6 | 14
Carcinoma, Hepatocellular 6 | 228
Fatty Liver 6 | 70
Female infertility 6 | 30
Kidney cancer 6 | 2,613
Liver carcinoma 6 | 240
Menopausal flushing 6 | 17
Pick disease 6 | 1,894
Postmenopausal osteoporosis 6 | 19
astrocytoma 6 | 1,146
esophageal adenocarcinoma 6 | 737
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary pancreatic ductal adenocarcinoma 6 | 1,109
Acute promyelocytic leukemia, FAB M3 5 | 11
Atrophic vulva 5 | 6
Chloasma 5 | 6
Cholestasis 5 | 155
Contraception 5 | 15
Depressive disorder 5 | 409
Facial Fine Wrinkling 5 | 5
Female hypogonadism syndrome 5 | 25
Fine Wrinkling 5 | 5
Heart disease 5 | 306
Hepatomegaly 5 | 285
Hyperinsulinism 5 | 133
Hyperkeratosis 5 | 50
Infertility 5 | 188
Infertility, Female 5 | 28
Liver disease 5 | 237
Mottle Hyperpigmentation 5 | 5
Premenstrual dysphoric disorder 5 | 8
Prostatic Neoplasms 5 | 495
Severe Recalcitrant Nodular Acne 5 | 5
Solar Lentigines 5 | 6
chronic rhinosinusitis 5 | 512
cutaneous lupus erythematosus 5 | 1,057
urothelial carcinoma 5 | 318
Alzheimer's disease 4 | 658
Atherosclerosis 4 | 291
Coronary artery disease 4 | 268
Delayed bone age 4 | 136
Hypertension 4 | 396
Male infertility 4 | 206
Mental Depression 4 | 333
dermatomyositis 4 | 966
fibroadenoma 4 | 559
nephrosclerosis 4 | 333
pediatric high grade glioma 4 | 1,064

Tissue

Endocrine System 53 | 18,159
Skin and soft tissues 53 | 17,230
Blood and immune system 52 | 16,909
Female tissues 52 | 17,400
Digestive Tract 51 | 17,369
Liver and Pancreas 50 | 16,750
Male tissues 50 | 17,142
Nervous System 49 | 16,725
Respiratory system 49 | 16,393
Urinary Tract 49 | 16,678
Cardiovascular System 46 | 15,192

Target Family

Nuclear Receptor 45 | 48
Non-IDG 6 | 12,091
Enzyme 1 | 4,145
oGPCR 1 | 421

GO Function

steroid hormone receptor activ... 53 | 53
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Peroxisome proliferator-activated receptor gamma PPARG Tclin Nuclear Receptor -3.96393 9579.5 773
Progesterone receptor PGR Tclin Nuclear Receptor -3.94412 7951.2 2098
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.62166 3805.7 575
Estrogen receptor beta ESR2 Tclin Nuclear Receptor -3.57388 3765.2 1096
Peroxisome proliferator-activated receptor alpha PPARA Tclin Nuclear Receptor -3.37176 2457.9 501
Hepatocyte nuclear factor 4-alpha HNF4A Tchem Nuclear Receptor -3.19918 1373.3 664
Nuclear receptor subfamily 1 group I member 2 NR1I2 Tchem Nuclear Receptor -3.15331 1582.6 305
Mineralocorticoid receptor NR3C2 Tclin Nuclear Receptor -3.08863 1005.8 203
Retinoic acid receptor alpha RARA Tclin Nuclear Receptor -2.97339 919.3 562