Development Level

Tclin 4 | 613
Tchem 3 | 1,598
Tbio 1 | 11,445

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

abnormal retinal blood vessel ... 1 | 26
abnormal skin coloration 1 | 25
female infertility 1 | 60
male infertility 1 | 123

Disease

Carcinoma 6 | 11,493
Multiple Sclerosis 5 | 540
Relapsing remitting multiple sclerosis 4 | 14
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
osteosarcoma 4 | 7,950
Astrocytoma, Pilocytic 3 | 3,081
Cancer 3 | 2,499
Diabetes Mellitus, Experimental 3 | 108
Lymphopenia 3 | 67
atypical teratoid / rhabdoid tumor 3 | 5,112
interstitial cystitis 3 | 2,312
pediatric high grade glioma 3 | 1,064
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Vascular disease 2 | 319
astrocytic glioma 2 | 2,597
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
non-small cell lung cancer 2 | 2,890
ovarian cancer 2 | 8,520
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
psoriasis 2 | 6,694
ulcerative colitis 2 | 1,819
Animal Mammary Neoplasms 1 | 136
Autosomal recessive nonsyndromic deafness 68 1 | 4
Autosomal recessive predisposition 1 | 1,442
Bipolar Disorder 1 | 666
Breast cancer 1 | 3,578
Colitis, Ulcerative 1 | 59
DEAFNESS, AUTOSOMAL RECESSIVE 68 1 | 1
Fibrosis 1 | 44
Heart Diseases 1 | 43
Infantile onset 1 | 238
Infarction, Middle Cerebral Artery 1 | 33
Leukemia 1 | 104
Liver Cirrhosis, Experimental 1 | 769
Liver cancer 1 | 604
MYELODYSPLASTIC SYNDROME 1 | 53
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Memory Disorders 1 | 40
Myelodysplastic Syndromes 1 | 26
Neoplasm Invasiveness 1 | 161
Nonsyndromic deafness 1 | 142
Pick disease 1 | 1,894
Scleroderma, Systemic 1 | 13
Sensorineural Hearing Loss (disorder) 1 | 284
X-linked cerebral adrenoleukodystrophy 1 | 116
adult high grade glioma 1 | 3,801
astrocytoma 1 | 1,146
atypical teratoid/rhabdoid tumor 1 | 357
breast carcinoma 1 | 1,638
cutaneous lupus erythematosus 1 | 1,057
cystic fibrosis 1 | 1,696
ductal carcinoma in situ 1 | 1,745
fibroadenoma 1 | 559
group 3 medulloblastoma 1 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
lung carcinoma 1 | 2,843
malignant mesothelioma 1 | 3,232
medulloblastoma, large-cell 1 | 6,241
oligodendroglioma 1 | 2,850
pancreatic cancer 1 | 2,398
primary pancreatic ductal adenocarcinoma 1 | 1,109
sonic hedgehog group medulloblastoma 1 | 467
subependymal giant cell astrocytoma 1 | 2,287
type I diabetes mellitus 1 | 22

Tissue

Nervous System 8 | 16,725
Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

GPCR 6 | 408
Kinase 2 | 634

GO Function

sphingosine-1-phosphate recept... 8 | 8
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingosine 1-phosphate receptor 5 S1PR5 Tclin GPCR -1.70131 47.1 273
Sphingosine 1-phosphate receptor 3 S1PR3 Tclin GPCR -2.25158 157.8 392
Sphingosine 1-phosphate receptor 4 S1PR4 Tclin GPCR -1.78966 58.4 256
Sphingosine kinase 1 SPHK1 Tchem Kinase -2.72994 583.6 518
G-protein coupled receptor 6 GPR6 Tbio GPCR -1.06924 11.5 63
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Sphingosine 1-phosphate receptor 1 S1PR1 Tclin GPCR -2.66220 474.4 526
Sphingosine 1-phosphate receptor 2 S1PR2 Tchem GPCR -2.30735 191.0 208