Development Level

Tbio 19 | 10,625

IMPC Term

absent pinna reflex 2 | 21
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating amylase ... 2 | 24
decreased circulating choleste... 2 | 85
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
impaired righting response 2 | 19
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased or absent threshold ... 2 | 128
increased rib number 2 | 41
persistence of hyaloid vascula... 2 | 22
stereotypic behavior 2 | 3
trunk curl 2 | 15
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal digit morphology 1 | 13
abnormal glucose homeostasis 1 | 5
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
corneal opacity 1 | 25
decreased Ly6C low monocyte nu... 1 | 23
decreased body weight 1 | 174
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
fused cornea and lens 1 | 4
fused phalanges 1 | 1
hyperactivity 1 | 108
impaired pupillary reflex 1 | 14
improved glucose tolerance 1 | 56
increased Ly6C high monocyte n... 1 | 12
increased NK T cell number 1 | 11
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
limb grasping 1 | 35
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260

Disease

osteosarcoma 14 | 7,933
medulloblastoma, large-cell 11 | 6,234
ependymoma 10 | 2,514
pilocytic astrocytoma 10 | 3,086
Carcinoma 9 | 2,147
glioblastoma 9 | 5,572
oligodendroglioma 9 | 2,849
lung cancer 8 | 4,473
psoriasis 8 | 6,685
subependymal giant cell astrocytoma 8 | 2,287
atypical teratoid / rhabdoid tumor 7 | 4,369
malignant mesothelioma 7 | 3,163
pediatric high grade glioma 7 | 2,712
primitive neuroectodermal tumor 7 | 3,031
colon cancer 6 | 1,475
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
ovarian cancer 6 | 8,492
pituitary cancer 6 | 1,972
Pick disease 5 | 1,893
adult high grade glioma 5 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
lung carcinoma 5 | 2,844
sonic hedgehog group medulloblastoma 5 | 1,482
Atopic dermatitis 4 | 944
Retinitis pigmentosa 4 | 156
adrenocortical carcinoma 4 | 1,427
astrocytic glioma 4 | 2,241
Blindness 3 | 84
Breast cancer 3 | 3,099
Melanoma 3 | 261
Nonsyndromic deafness 3 | 121
Sensorineural hearing loss 3 | 107
Usher Syndrome, Type 1 3 | 7
Usher syndrome 3 | 34
acute quadriplegic myopathy 3 | 1,157
astrocytoma 3 | 1,493
cystic fibrosis 3 | 1,670
dermatomyositis 3 | 967
ductal carcinoma in situ 3 | 1,745
esophageal adenocarcinoma 3 | 737
group 3 medulloblastoma 3 | 2,254
invasive ductal carcinoma 3 | 2,950
medulloblastoma 3 | 1,524
nephrosclerosis 3 | 329
posterior fossa group A ependymoma 3 | 1,511
ulcerative colitis 3 | 2,087
Bone Diseases, Developmental 2 | 25
Congenital hemolytic anemia 2 | 31
Down syndrome 2 | 548
Hereditary elliptocytosis 2 | 20
Hereditary spherocytosis 2 | 20
Hypertension 2 | 293
Major Depressive Disorder 2 | 106
atypical teratoid/rhabdoid tumor 2 | 1,095
cutaneous lupus erythematosus 2 | 1,056
diabetes mellitus 2 | 1,663
glioblastoma multiforme 2 | 347
non-small cell lung cancer 2 | 2,798
pancreatic cancer 2 | 2,300
primary pancreatic ductal adenocarcinoma 2 | 1,271
sarcoidosis 2 | 368
spina bifida 2 | 1,064
Amyotrophic Lateral Sclerosis 1 | 432
Anemia 1 | 252
Autistic Disorder 1 | 320
Bipolar Disorder 1 | 266
Brugada syndrome 1 | 26
Carpenter syndrome 1 | 13
Ciliopathy 1 | 57
Craniofacial Abnormalities 1 | 147
Deafness, Autosomal Recessive 18 1 | 1
Deafness, autosomal recessive, 18A 1 | 1
Disease of anatomical entity 1 | 25
Exhibitionism 1 | 7
Gilles de la Tourette syndrome 1 | 47
Influenza 1 | 142
Kidney cancer 1 | 121
Leber congenital amaurosis 1 | 72
Liver carcinoma 1 | 217
Long QT syndrome 1 | 53
Long QT syndrome 1 1 | 12
Mental depression 1 | 58
Parkinson's disease 1 | 364
Polycystic kidney disease 1 | 54
Renal Cell Carcinoma 1 | 199
Romano-Ward Syndrome 1 | 12
Situs Inversus 1 | 52
Skin cancer 1 | 37
Status Epilepticus 1 | 85
Testicular cancer 1 | 24
USHER SYNDROME, TYPE IC 1 | 1
USHER SYNDROME, TYPE IG 1 | 2
Usher syndrome 1C 1 | 1
Usher syndrome type 1G 1 | 2
Usher syndrome type 2 1 | 5
Weight Gain 1 | 87
chorea-acanthocytosis 1 | 11
cystic fibrosis and chronic rhinosinusitis 1 | 213
hereditary spastic paraplegia 1 | 313

Tissue

Blood and immune system 19 | 17,995
Cardiovascular System 19 | 17,958
Digestive Tract 19 | 18,473
Endocrine System 19 | 18,512
Female tissues 19 | 18,647
Liver and Pancreas 19 | 18,136
Male tissues 19 | 17,969
Nervous System 19 | 18,561
Respiratory system 19 | 17,484
Skin and soft tissues 19 | 18,115
Urinary Tract 19 | 18,444

Target Family

Non-IDG 16 | 11,969
Enzyme 3 | 4,146

GO Function

spectrin binding 19 | 19
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.03835 107.4 139
Ankyrin-2 ANK2 Tbio Non-IDG -2.04838 107.1 205
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.10835 131.7 114
Harmonin USH1C Tbio Non-IDG -2.07484 115.8 173
Usher syndrome type-1G protein USH1G Tbio Non-IDG -1.60987 35.1 15
Unconventional myosin-X MYO10 Tbio Non-IDG -1.45944 32.9 38
Dynactin subunit 2 DCTN2 Tbio Non-IDG -1.88407 67.3 222
Ankyrin-3 ANK3 Tbio Non-IDG -2.22055 146.7 148
Cytoplasmic dynein 1 intermediate chain 1 DYNC1I1 Tbio Non-IDG -0.73316 5.91 81
Beta-adducin ADD2 Tbio Enzyme -2.00279 104.4 132