Development Level

Tbio 25 | 11,651
Tclin 1 | 612

IMPC Phenotype

increased or absent threshold ... 3 | 101
absent pinna reflex 2 | 23
impaired righting response 2 | 26
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
persistence of hyaloid vascula... 2 | 33
stereotypic behavior 2 | 3
trunk curl 2 | 16
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal locomotor activation 1 | 16
abnormal retina morphology 1 | 71
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
fused cornea and lens 1 | 5
fused phalanges 1 | 1
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased mean corpuscular hem... 1 | 36
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 22 | 11,493
osteosarcoma 17 | 7,950
medulloblastoma, large-cell 15 | 6,241
ependymoma 14 | 4,679
adult high grade glioma 13 | 3,801
psoriasis 13 | 6,694
glioblastoma 12 | 5,792
atypical teratoid / rhabdoid tumor 11 | 5,112
Astrocytoma, Pilocytic 10 | 3,081
Kidney cancer 10 | 2,613
lung cancer 9 | 4,740
oligodendroglioma 9 | 2,850
ovarian cancer 9 | 8,520
subependymal giant cell astrocytoma 9 | 2,287
group 3 medulloblastoma 8 | 4,104
pituitary cancer 8 | 1,972
primitive neuroectodermal tumor 8 | 3,035
Breast cancer 7 | 3,578
Melanoma 7 | 711
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung carcinoma 7 | 2,843
malignant mesothelioma 7 | 3,232
Intellectual disability 6 | 1,016
colon cancer 6 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pancreatic cancer 6 | 2,398
Atopic dermatitis 5 | 952
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Pick disease 5 | 1,894
Poor school performance 5 | 645
astrocytic glioma 5 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
Autosomal recessive predisposition 4 | 1,442
Hypertension 4 | 396
Nonsyndromic deafness 4 | 142
Retinitis Pigmentosa 4 | 226
Schizophrenia 4 | 1,160
Skin cancer 4 | 469
Usher syndrome 4 | 32
acute quadriplegic myopathy 4 | 1,158
adrenocortical carcinoma 4 | 1,428
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,855
invasive ductal carcinoma 4 | 2,951
juvenile dermatomyositis 4 | 1,187
primary pancreatic ductal adenocarcinoma 4 | 1,109
Blindness 3 | 88
Cataract 3 | 297
Cognitive delay 3 | 608
Difficulties with night vision 3 | 87
Down syndrome 3 | 499
Electroretinogram abnormal 3 | 95
Endometrial cancer 3 | 311
Global developmental delay 3 | 608
Lens Opacities 3 | 231
Liver cancer 3 | 604
Mental and motor retardation 3 | 608
Night Blindness 3 | 101
Sensorineural Hearing Loss (disorder) 3 | 284
Sensorineural hearing loss 3 | 106
Usher Syndrome, Type 1 3 | 7
Usher Syndrome, Type I 3 | 6
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
lung adenocarcinoma 3 | 2,716
medulloblastoma 3 | 720
nephrosclerosis 3 | 333
Anemia 2 | 365
Asthma 2 | 385
Atrial Fibrillation 2 | 124
Bipolar Disorder 2 | 666
Cerebellar hypoplasia and atrophy 2 | 41
Chronic Lymphocytic Leukemia 2 | 262
Depressive disorder 2 | 409
Duchenne muscular dystrophy 2 | 601
Essential Hypertension 2 | 94
Extinguished electroretinogram 2 | 15
Major Depressive Disorder 2 | 301
Mental Depression 2 | 333
Mood Disorders 2 | 184
Motor delay 2 | 147
Neuropathy 2 | 261
No development of motor milestones 2 | 147
Rheumatoid arthritis 2 | 1,191
active Crohn's disease 2 | 922
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
gastric carcinoma 2 | 807
hepatocellular carcinoma 2 | 547
mucosa-associated lymphoid tissue lymphoma 2 | 484
non-small cell lung cancer 2 | 2,890
sarcoidosis 2 | 370
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 26 | 16,909
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Male tissues 26 | 17,142
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678
Liver and Pancreas 25 | 16,750
Nervous System 25 | 16,725
Cardiovascular System 23 | 15,192

Target Family

Non-IDG 21 | 12,091
Enzyme 4 | 4,145
Transporter 1 | 473

GO Function

spectrin binding 26 | 26
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Spectrin beta chain, non-erythrocytic 5 SPTBN5 Tbio Non-IDG -0.41365 2.99 32
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Usher syndrome type-1G protein USH1G Tbio Non-IDG -1.64281 40.2 24
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.06068 113.6 153
Band 4.1-like protein 2 EPB41L2 Tbio Non-IDG -1.36757 26.5 173
Dynactin subunit 2 DCTN2 Tbio Non-IDG -1.88460 67.4 257
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 Tbio Non-IDG -1.22176 19.3 165
Dematin DMTN Tbio Non-IDG -1.73686 56.6 158
Beta-adducin ADD2 Tbio Enzyme -2.01804 106.5 147
Cytoplasmic dynein 1 intermediate chain 1 DYNC1I1 Tbio Non-IDG -0.74893 5.97 92