Development Level

Tbio 8 | 11,445
Tdark 7 | 6,588
Tchem 5 | 1,598
Tclin 4 | 613

IMPC Phenotype

increased circulating HDL chol... 1 | 80
increased circulating creatini... 1 | 38

Disease

Carcinoma 21 | 11,493
lung cancer 9 | 4,740
medulloblastoma, large-cell 9 | 6,241
psoriasis 9 | 6,694
osteosarcoma 8 | 7,950
ovarian cancer 7 | 8,520
Cholestasis 6 | 155
Gout 6 | 106
Hyperuricemia 6 | 49
lung carcinoma 6 | 2,843
glioblastoma 5 | 5,792
group 3 medulloblastoma 5 | 4,104
nephrosclerosis 5 | 333
non-small cell lung cancer 5 | 2,890
Chronic gouty arthritis 4 | 4
Kidney cancer 4 | 2,613
Rheumatoid arthritis 4 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
pancreatic cancer 4 | 2,398
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Adjunct Treatment to Inhibit Renal Drug Excretion 3 | 3
Articular gout 3 | 11
Autosomal recessive predisposition 3 | 1,442
Bilirubin metabolic disorder 3 | 41
Cancer 3 | 2,499
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
adult high grade glioma 3 | 3,801
atypical teratoid / rhabdoid tumor 3 | 5,112
interstitial cystitis 3 | 2,312
malignant mesothelioma 3 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
Abnormal pigmentation 2 | 25
Abnormality of the skeletal system 2 | 11
Acute kidney injury 2 | 70
Adverse reaction to drug 2 | 61
Attention deficit hyperactivity disorder 2 | 278
Breast cancer 2 | 3,578
Chronic cholangitis 2 | 3
Conjugated hyperbilirubinemia 2 | 14
Drug-Related Side Effects and Adverse Reactions 2 | 62
Extrahepatic cholestasis 2 | 2
HYPERBILIRUBINEMIA, ROTOR TYPE 2 | 2
Icterus 2 | 82
Keratoconjunctivitis sicca 2 | 25
Kidney disease 2 | 430
Liver disease 2 | 237
Melanoma 2 | 711
Pick disease 2 | 1,894
Prevention of Cardiac Transplant Rejection 2 | 15
Prevention of Kidney Transplant Rejection 2 | 17
Prevention of Liver Transplant Rejection 2 | 15
Rotor Syndrome 2 | 2
Severe Recalcitrant Psoriasis 2 | 12
Skin cancer 2 | 469
Tear film insufficiency 2 | 15
adrenocortical carcinoma 2 | 1,428
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
ependymoma 2 | 4,679
pediatric high grade glioma 2 | 1,064
Abnormality of epiphysis morphology 1 | 39
Acquired metabolic disease 1 | 336
Acromegaly 1 | 51
Alcoholic Intoxication, Chronic 1 | 289
Arthralgia 1 | 90
Blepharoptosis 1 | 231
Bone pain 1 | 42
Breast Neoplasms 1 | 445
Chemical and Drug Induced Liver Injury 1 | 195
Coarse facial features 1 | 108
Colonic Neoplasms 1 | 142
Congenital clubfoot 1 | 109
Hyperhidrosis disorder 1 | 81
Impotence 1 | 42
Increased sweating 1 | 81
Influenza 1 | 142
Influenza, Human 1 | 51
Kidney Failure 1 | 111
Liver Cirrhosis 1 | 181
Liver Cirrhosis, Experimental 1 | 769
Lung Neoplasms 1 | 232
Lymphoid leukemia 1 | 160
Mammary Neoplasms 1 | 425
Muscular Diseases 1 | 27
Myopathy 1 | 185
Neonatal Jaundice 1 | 30
Osteomyelitis 1 | 42
Ptosis 1 | 48
Sweating 1 | 81
Thickened facial skin with coarse facial features 1 | 108
atypical teratoid/rhabdoid tumor 1 | 357
glioblastoma multiforme 1 | 142
pulmonary arterial hypertension 1 | 75

Tissue

Urinary Tract 19 | 16,678
Endocrine System 17 | 18,159
Digestive Tract 16 | 17,369
Liver and Pancreas 16 | 16,750
Nervous System 15 | 16,725
Female tissues 14 | 17,400
Male tissues 14 | 17,142
Blood and immune system 13 | 16,909
Skin and soft tissues 12 | 17,230
Cardiovascular System 10 | 15,192
Respiratory system 9 | 16,393

Target Family

Transporter 24 | 473

GO Function

sodium-independent organic ani... 24 | 24
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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