Development Level

Tbio 20 | 11,445
Tchem 6 | 1,598
Tdark 4 | 6,588
Tclin 1 | 613

Collection

Ion Channel: IDG Consortium (T... 4 | 99

IMPC Phenotype

abnormal seminal vesicle morph... 2 | 114
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal retina morphology 1 | 71
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged kidney 1 | 14
hypoactivity 1 | 132
increased circulating alkaline... 1 | 122
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small testis 1 | 58

Disease

medulloblastoma, large-cell 16 | 6,241
psoriasis 15 | 6,694
glioblastoma 14 | 5,792
ovarian cancer 14 | 8,520
Carcinoma 13 | 11,493
atypical teratoid / rhabdoid tumor 13 | 5,112
adult high grade glioma 12 | 3,801
osteosarcoma 12 | 7,950
primitive neuroectodermal tumor 12 | 3,035
Astrocytoma, Pilocytic 11 | 3,081
astrocytic glioma 11 | 2,597
lung cancer 11 | 4,740
oligodendroglioma 11 | 2,850
pituitary cancer 11 | 1,972
ependymoma 10 | 4,679
group 3 medulloblastoma 10 | 4,104
Breast cancer 9 | 3,578
Pick disease 9 | 1,894
colon cancer 9 | 1,478
lung carcinoma 9 | 2,843
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung adenocarcinoma 8 | 2,716
subependymal giant cell astrocytoma 8 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
malignant mesothelioma 7 | 3,232
Brugada syndrome 6 | 29
Hypertension 6 | 396
ductal carcinoma in situ 6 | 1,745
invasive ductal carcinoma 6 | 2,951
Liver Cirrhosis, Experimental 5 | 769
Sudden infant death syndrome 5 | 32
spina bifida 5 | 1,074
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 4 | 21
Cancer 4 | 2,499
Epilepsy 4 | 792
Familial atrial fibrillation 4 | 23
Kidney cancer 4 | 2,613
Long QT syndrome 4 | 39
Schizophrenia 4 | 1,160
active ulcerative colitis 4 | 764
acute quadriplegic myopathy 4 | 1,158
adrenocortical carcinoma 4 | 1,428
cystic fibrosis 4 | 1,696
group 4 medulloblastoma 4 | 1,855
non-small cell lung cancer 4 | 2,890
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Brugada Syndrome (disorder) 3 | 15
Cardiac Arrhythmia 3 | 103
Diabetes Mellitus, Experimental 3 | 108
Heart disease 3 | 306
Hypertensive disease 3 | 292
Kidney disease 3 | 430
Seizures 3 | 596
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
pediatric high grade glioma 3 | 1,064
ulcerative colitis 3 | 1,819
Arrhythmogenic right ventricular cardiomyopathy 2 | 30
Atopic dermatitis 2 | 952
Atrial Fibrillation 2 | 124
Bipolar Disorder 2 | 666
Cardiac conduction abnormalities 2 | 78
Cardiomyopathies 2 | 110
Cardiomyopathy 2 | 116
Cerebrovascular disease 2 | 238
Conduction disorder of the heart 2 | 79
Congestive heart failure 2 | 113
Depressive disorder 2 | 409
Disease of mental health 2 | 36
Down syndrome 2 | 499
Duchenne muscular dystrophy 2 | 601
EKG abnormalities 2 | 78
Electrocardiogram abnormal 2 | 81
Electrocardiogram change 2 | 78
Heart failure 2 | 162
Hyperalgesia 2 | 83
Long QT syndrome 1 2 | 20
Mental Depression 2 | 333
Multiple myeloma 2 | 1,332
Nonsyndromic deafness 2 | 142
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Romano-Ward Syndrome 2 | 12
Sudden Cardiac Death 2 | 29
Vascular disease 2 | 319
Ventricular Fibrillation 2 | 17
Ventricular arrhythmia 2 | 27
active Crohn's disease 2 | 922
acute myeloid leukemia 2 | 783
atypical teratoid/rhabdoid tumor 2 | 357
cutaneous lupus erythematosus 2 | 1,057
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
posterior fossa group B ependymoma 2 | 416
primary pancreatic ductal adenocarcinoma 2 | 1,109

Tissue

Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678
Blood and immune system 28 | 16,909
Nervous System 28 | 16,725
Cardiovascular System 27 | 15,192

Target Family

Ion Channel 11 | 344
Enzyme 10 | 4,145
Non-IDG 7 | 12,091
Kinase 3 | 634

GO Function

sodium channel regulator activ... 31 | 31
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
FXYD domain-containing ion transport regulator 3 FXYD3 Tbio Ion Channel -1.78093 58.4 76
Sodium channel and clathrin linker 1 SCLT1 Tdark Non-IDG -0.50820 2.61 97
Sodium/potassium-transporting ATPase subunit gamma FXYD2 Tclin Enzyme -1.58017 39.0 64
Sodium channel subunit beta-4 SCN4B Tbio Ion Channel -1.42029 24.1 85
Tyrosine-protein phosphatase non-receptor type 3 PTPN3 Tbio Enzyme -1.40961 29.1 162
Serine protease 41 PRSS41 Tdark Enzyme 0.00000 0
FXYD domain-containing ion transport regulator 4 FXYD4 Tdark Ion Channel -0.81692 5.29 14
Prostasin PRSS8 Tchem Enzyme -1.99808 113.0 199
Putative FXYD domain-containing ion transport regulator 8 FXYD6P3 Tdark Ion Channel 0.00000 0