Development Level

Tchem 6 | 1,598
Tbio 3 | 11,445
Tclin 1 | 613

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

abnormal heart morphology 1 | 162
decreased circulating alkaline... 1 | 46
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydrometra 1 | 53
increased heart weight 1 | 62
increased monocyte cell number 1 | 63
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74

Disease

Carcinoma 9 | 11,493
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
medulloblastoma, large-cell 4 | 6,241
Liver cancer 3 | 604
atypical teratoid / rhabdoid tumor 3 | 5,112
cystic fibrosis 3 | 1,696
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
ovarian cancer 3 | 8,520
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
Cardiac Arrhythmia 2 | 103
Cardiac conduction abnormalities 2 | 78
Conduction disorder of the heart 2 | 79
EKG abnormalities 2 | 78
Edema 2 | 81
Electrocardiogram abnormal 2 | 81
Electrocardiogram change 2 | 78
Hypertensive disorder 2 | 56
Hypokalemia 2 | 52
Hypokalemia Prevention 2 | 6
Kidney cancer 2 | 2,613
Melanoma 2 | 711
X-linked endothelial corneal dystrophy 2 | 9
adult high grade glioma 2 | 3,801
interstitial cystitis 2 | 2,312
lung cancer 2 | 4,740
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
psoriasis 2 | 6,694
subependymal giant cell astrocytoma 2 | 2,287
Autosomal dominant polycystic kidney disease 1 | 31
Autosomal recessive nonsyndromic deafness 13 1 | 1
Birk-Barel syndrome 1 | 8
Blastomycosis 1 | 12
Bradycardia 1 | 36
Bronchiectasis 1 | 64
Bronchitis, Chronic 1 | 12
Brugada Syndrome (disorder) 1 | 15
Cerebral Ischemia 1 | 37
Cervical Dystonia 1 | 26
Chandler syndrome 1 | 6
Congenital adrenal hyperplasia 1 | 73
Congenital hereditary endothelial dystrophy of cornea 1 | 8
Corneal edema 1 | 14
Decreased plasma renin activity 1 | 9
Dehydration 1 | 40
Dentin sensitivity 1 | 14
Disturbance in mood 1 | 3
Episodic ataxia 1 | 22
Fascioliasis 1 | 17
Fatigue 1 | 182
Fibromyalgia 1 | 19
Frozen shoulder 1 | 5
Fuchs Endothelial Dystrophy 1 | 5
Fuchs' endothelial dystrophy 1 | 24
Hydrarthrosis 1 | 4
Hyperactive renin-angiotensin system 1 | 8
Hyperaldosteronism 1 | 35
Hyperkalemia 1 | 17
Hyponatremia 1 | 25
Hypotension 1 | 82
Idiopathic bronchiectasis 1 | 4
Increased plasma renin activity 1 | 8
Inflammation 1 | 120
Keratoconus 1 | 113
Kidney Diseases 1 | 114
Kidney damage 1 | 25
Leprosy 1 | 73
Liddle syndrome 1 | 14
Metabolic acidosis 1 | 90
Muscle Weakness 1 | 170
Nonorganic psychosis 1 | 84
Pain 1 | 103
Paronychia 1 | 7
Peripheral Edema due to Chronic Heart Failure 1 | 10
Peters anomaly 1 | 16
Posterior polymorphous corneal dystrophy 1 | 19
Prolonged QT interval 1 | 15
Pseudohypoaldosteronism 1 | 23
Pseudohypoaldosteronism, Type I, Autosomal Recessive 1 | 3
Pulmonary Edema due to Chronic Heart Failure 1 | 6
Recurrent respiratory infections 1 | 141
Renal salt wasting 1 | 18
Retinal disease 1 | 25
Right bundle branch block 1 | 17
Sensorineural hearing loss 1 | 106
Syncope 1 | 22
Thiel-Behnke corneal dystrophy 1 | 6
Visceral leishmaniasis 1 | 14
autosomal recessive pseudohypoaldosteronism type 1 1 | 3

Tissue

Endocrine System 10 | 18,159
Male tissues 10 | 17,142
Digestive Tract 9 | 17,369
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678
Blood and immune system 8 | 16,909
Cardiovascular System 6 | 15,192

Target Family

Ion Channel 9 | 344
Transporter 1 | 473

GO Function

sodium channel activity 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transient receptor potential cation channel subfamily M member 2 TRPM2 Tchem Ion Channel -1.34318 25.1 209
Acid-sensing ion channel 3 ASIC3 Tchem Ion Channel -2.28745 195.8 130
Transient receptor potential cation channel subfamily M member 5 TRPM5 Tchem Ion Channel -1.98611 95.5 113
Sodium bicarbonate transporter-like protein 11 SLC4A11 Tbio Transporter -1.87650 77.5 77
Potassium channel subfamily K member 1 KCNK1 Tbio Ion Channel -1.91364 80.5 208
Transient receptor potential cation channel subfamily M member 4 TRPM4 Tchem Ion Channel -2.19653 160.9 186
Polycystic kidney disease 2-like 1 protein PKD2L1 Tchem Ion Channel -1.95186 96.8 100
Amiloride-sensitive sodium channel subunit gamma SCNN1G Tclin Ion Channel -2.10269 131.1 212
Sodium leak channel non-selective protein NALCN Tchem Ion Channel -1.72377 54.1 62
Acid-sensing ion channel 4 ASIC4 Tbio Ion Channel -1.16480 13.1 113