1. Home
  2. Targets
Target Filters...

Development Level

Tbio 8 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal incisor color 1 | 3
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal spine curvature 1 | 9
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased fasted circulating g... 1 | 65
eyelids fail to open 1 | 3
impaired glucose tolerance 1 | 75
increased circulating alkaline... 1 | 122
increased grip strength 1 | 41
kyphosis 1 | 5
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 8 | 11,493
Hyperphosphatemia 5 | 32
Hypophosphatemia 5 | 40
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
ovarian cancer 4 | 8,520
Liver Cirrhosis, Experimental 3 | 769
adult high grade glioma 3 | 3,801
medulloblastoma, large-cell 3 | 6,241
nephrosclerosis 3 | 333
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Autosomal recessive predisposition 2 | 1,442
Basal ganglia calcification 2 | 27
Calcinosis 2 | 70
Fanconi syndrome 2 | 14
Gout 2 | 106
Hyperuricemia 2 | 49
Iron metabolism disease 2 | 20
Nephrolithiasis 2 | 56
Osteomalacia 2 | 35
Peripheral vascular disease 2 | 87
Pulmonary alveolar microlithiasis 2 | 4
Rickets 2 | 49
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
non-small cell lung cancer 2 | 2,890
osteosarcoma 2 | 7,950
pancreatic cancer 2 | 2,398
psoriasis 2 | 6,694
ulcerative colitis 2 | 1,819
Adult Fanconi syndrome 1 | 12
Adult onset 1 | 82
Adverse reaction to drug 1 | 61
Ankylosing spondylitis 1 | 140
Aortic Valve, Calcification of 1 | 3
Aortic valve calcification 1 | 5
Athetosis 1 | 16
Barrett's esophagus 1 | 182
Basal Ganglia Calcification, Idiopathic, 1 1 | 5
Basal Ganglia Diseases 1 | 14
Bladder exstrophy 1 | 32
Bone Diseases, Developmental 1 | 27
Bone Diseases, Metabolic 1 | 14
Bradykinesia 1 | 34
Calcification of the small brain vessels 1 | 3
Carcinoma, Non-Small-Cell Lung 1 | 107
Cardiovascular system disease 1 | 246
Cerebral calcification 1 | 43
Chorea 1 | 29
Choreatic disease 1 | 52
Clouding of corneal stroma 1 | 50
Corneal Opacity 1 | 53
Decreased platelet count 1 | 111
Dense calcifications in the cerebellar dentate nucleus 1 | 3
Dent disease 1 | 18
Dilated ventricles (finding) 1 | 121
Drug-Related Side Effects and Adverse Reactions 1 | 62
Dysarthria 1 | 192
Dysdiadochokinesis 1 | 25
Dystonia 1 | 164
Dystonic disease 1 | 106
Fahr's syndrome (disorder) 1 | 4
Forgetful 1 | 40
Generalized aminoaciduria 1 | 9
Generalized osteopenia 1 | 99
Glycogen storage disease 1 | 39
Glycosuria 1 | 29
Haemorrhage subcutaneous 1 | 10
Hypercalcemia 1 | 59
Hypercalciuria 1 | 27
Hyperphosphaturia 1 | 21
Hyperreflexia 1 | 209
Hypochromic anemia 1 | 9
Increased susceptibility to fractures 1 | 21
Kidney Failure 1 | 111
Limb dysmetria 1 | 4
Liver Cirrhosis 1 | 181
Malformations of Cortical Development, Group II 1 | 31
Mask-like facies 1 | 25
Memory Loss 1 | 40
Memory impairment 1 | 40
Mental deterioration 1 | 32
Muscle Rigidity 1 | 49
Muscle Weakness 1 | 170
Osteopenia 1 | 99
Osteoporosis 1 | 363
Parkinsonian Disorders 1 | 56
Postural instability 1 | 19
Progressive disorder 1 | 142
Renal Insufficiency 1 | 90
Renal failure in adulthood 1 | 76
Renal phosphate wasting 1 | 7
Restrictive respiratory syndrome 1 | 3
Slow progression 1 | 89
Thrombocytopenia 1 | 197
Tremor 1 | 113
Urinary Incontinence 1 | 50
Urine phosphorous concentration above normal 1 | 21
facioscapulohumeral dystrophy 1 | 288
lingual-facial-buccal dyskinesia 1 | 13
non-small cell lung carcinoma 1 | 317

Tissue

Liver and Pancreas 9 | 16,750
Urinary Tract 9 | 16,678
Endocrine System 8 | 18,159
Male tissues 8 | 17,142
Digestive Tract 7 | 17,369
Respiratory system 7 | 16,393
Nervous System 6 | 16,725
Skin and soft tissues 6 | 17,230
Blood and immune system 5 | 16,909
Female tissues 5 | 17,400
Cardiovascular System 3 | 15,192

Target Family

Transporter 9 | 473

GO Function

sodium:phosphate symporter act... 9 | 9
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium-dependent phosphate transport protein 1 SLC17A1 Tbio Transporter -1.73498 53.1 39
Sodium-dependent phosphate transporter 2 SLC20A2 Tbio Transporter -2.29276 197.3 107
Sodium-dependent phosphate transport protein 2A SLC34A1 Tbio Transporter -1.98345 87.1 65
Sodium-dependent phosphate transport protein 4 SLC17A3 Tbio Transporter -1.10877 13.3 46
Sodium-dependent phosphate transport protein 2C SLC34A3 Tbio Transporter -1.70291 49.1 73
Probable small intestine urate exporter SLC17A4 Tdark Transporter -0.15550 1.70 44
Sodium-dependent phosphate transporter 1 SLC20A1 Tbio Transporter -1.79308 59.6 101
Sodium-dependent phosphate transport protein 3 SLC17A2 Tbio Transporter -0.17609 1.23 63
Sodium-dependent phosphate transport protein 2B SLC34A2 Tbio Transporter -2.06890 115.2 75