Development Level

Tbio 33 | 11,445
Tchem 5 | 1,598
Tdark 3 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
increased grip strength 2 | 41
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal tibia morphology 1 | 14
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased startle reflex 1 | 112
small kidney 1 | 16
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 29 | 11,493
osteosarcoma 23 | 7,950
ovarian cancer 22 | 8,520
lung cancer 21 | 4,740
glioblastoma 19 | 5,792
psoriasis 19 | 6,694
medulloblastoma, large-cell 18 | 6,241
ependymoma 16 | 4,679
group 3 medulloblastoma 15 | 4,104
adult high grade glioma 11 | 3,801
atypical teratoid / rhabdoid tumor 11 | 5,112
Cancer 10 | 2,499
Kidney cancer 10 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Astrocytoma, Pilocytic 8 | 3,081
Breast cancer 8 | 3,578
astrocytic glioma 8 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
primitive neuroectodermal tumor 8 | 3,035
Influenza 7 | 142
Multiple myeloma 7 | 1,332
colon cancer 7 | 1,478
juvenile dermatomyositis 7 | 1,187
lung carcinoma 7 | 2,843
nasopharyngeal carcinoma 7 | 1,058
pancreatic cancer 7 | 2,398
Melanoma 6 | 711
Systemic lupus erythematosus 6 | 194
Waldenstrons macroglobulinemia 6 | 765
cutaneous lupus erythematosus 6 | 1,057
dermatomyositis 6 | 966
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
oligodendroglioma 6 | 2,850
primary Sjogren syndrome 6 | 735
ulcerative colitis 6 | 1,819
Multiple Sclerosis 5 | 540
Pick disease 5 | 1,894
active Crohn's disease 5 | 922
acute quadriplegic myopathy 5 | 1,158
atypical teratoid/rhabdoid tumor 5 | 357
diabetes mellitus 5 | 1,728
group 4 medulloblastoma 5 | 1,855
non-small cell lung cancer 5 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
Amyotrophic lateral sclerosis 4 | 451
Influenza, Human 4 | 51
Rheumatoid arthritis 4 | 1,191
cystic fibrosis 4 | 1,696
gastric cancer 4 | 459
hepatocellular carcinoma 4 | 547
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
subependymal giant cell astrocytoma 4 | 2,287
Adenocarcinoma of lung 3 | 142
Alcoholic Intoxication, Chronic 3 | 289
Cockayne syndrome 3 | 60
Hypersensitivity reaction type II disease 3 | 253
Intellectual disability 3 | 1,016
acute myeloid leukemia 3 | 783
astrocytoma 3 | 1,146
ductal carcinoma in situ 3 | 1,745
nephrosclerosis 3 | 333
pancreatic carcinoma 3 | 562
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
tuberculosis and treatment for 6 months 3 | 409
Arthritis 2 | 290
Congenital Epicanthus 2 | 177
Depressive disorder 2 | 409
Dermatitis 2 | 157
Disease Models, Animal 2 | 155
Inflammation 2 | 120
Lung disease 2 | 142
Mesothelioma, Malignant 2 | 105
Microcephaly 2 | 166
Microphthalmia with limb anomalies 2 | 40
Muscular dystrophy 2 | 75
Myocardial Ischemia 2 | 169
Neoplasm Invasiveness 2 | 161
Proximal muscle weakness 2 | 47
Proximal neurogenic muscle weakness 2 | 47
Skin cancer 2 | 469
Substance-Related Disorders 2 | 115
Vascular disease 2 | 319
Ventricular Septal Defects 2 | 119
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
breast carcinoma 2 | 1,638
chronic lymphosyte leukemia 2 | 204
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
hereditary spastic paraplegia 2 | 318
interstitial cystitis 2 | 2,312
limb girdle muscular dystrophy 2A 2 | 213
mucosa-associated lymphoid tissue lymphoma 2 | 484
pediatric high grade glioma 2 | 1,064

Tissue

Digestive Tract 41 | 17,369
Endocrine System 41 | 18,159
Female tissues 41 | 17,400
Blood and immune system 39 | 16,909
Liver and Pancreas 39 | 16,750
Male tissues 39 | 17,142
Respiratory system 39 | 16,393
Skin and soft tissues 39 | 17,230
Urinary Tract 39 | 16,678
Nervous System 38 | 16,725
Cardiovascular System 37 | 15,192

Target Family

Non-IDG 24 | 12,091
Enzyme 13 | 4,145
Epigenetic 3 | 242
Transcription Factor 2 | 1,400

GO Function

single-stranded RNA binding 42 | 42
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Chromobox protein homolog 8 CBX8 Tchem Epigenetic -2.27537 183.4 505
Heterogeneous nuclear ribonucleoprotein U HNRNPU Tbio Non-IDG -2.33813 207.8 169
Protein LSM14 homolog A LSM14A Tbio Non-IDG -1.13869 16.0 122
Toll-like receptor 7 TLR7 Tclin Non-IDG -3.02761 1078.4 759
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204
LINE-1 retrotransposable element ORF1 protein L1RE1 Tbio Non-IDG 0.00000 0
Probable ATP-dependent RNA helicase DHX58 DHX58 Tbio Enzyme -1.62683 45.9 286
LINE-1 type transposase domain-containing protein 1 L1TD1 Tbio Enzyme -0.55122 5.22 51
E3 SUMO-protein ligase CBX4 CBX4 Tchem Epigenetic -1.32793 21.9 353