Development Level

Tbio 3 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal coat- hair morphology 1 | 19
abnormal hair texture 1 | 4
decreased body weight 1 | 161
decreased total body fat amoun... 1 | 207
hypoactivity 1 | 132
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92

Disease

group 3 medulloblastoma 4 | 4,104
medulloblastoma, large-cell 4 | 6,241
primitive neuroectodermal tumor 4 | 3,035
Breast cancer 3 | 3,578
Werner syndrome 3 | 29
adult high grade glioma 3 | 3,801
atypical teratoid / rhabdoid tumor 3 | 5,112
glioblastoma 3 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
osteosarcoma 3 | 7,950
ovarian cancer 3 | 8,520
psoriasis 3 | 6,694
Carcinoma 2 | 11,493
Cognitive delay 2 | 608
Dull intelligence 2 | 645
Fanconi anemia 2 | 56
Global developmental delay 2 | 608
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Nijmegen breakage syndrome 2 | 24
Poor school performance 2 | 645
Short stature 2 | 531
Small head 2 | 374
colon cancer 2 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
non-small cell lung cancer 2 | 2,890
Acquired scoliosis 1 | 281
Almond-shaped eyes 1 | 23
Anemia 1 | 365
Aplastic Anemia 1 | 21
Autosomal recessive Robinow syndrome 1 | 27
Autosomal recessive predisposition 1 | 1,442
Bell Palsy 1 | 58
Blepharoptosis 1 | 231
Bloom syndrome 1 | 29
Breast Neoplasms 1 | 445
Cancer 1 | 2,499
Cholera 1 | 34
Chromosome Breakage 1 | 36
Chronic progressive external ophthalmoplegia 1 | 26
Cockayne syndrome 1 | 60
Compression of spinal cord 1 | 10
Convex nasal ridge 1 | 37
Creatine phosphokinase serum increased 1 | 110
Curvature of spine 1 | 282
Decreased platelet count 1 | 111
Dyspnea on exertion 1 | 24
Ectopic kidney 1 | 11
Elevated creatine kinase 1 | 110
Facial Paresis 1 | 59
Facial muscle weakness of muscles innervated by CN VII 1 | 58
Gait abnormality 1 | 135
Generalized amyotrophy 1 | 20
Genetic Predisposition to Disease 1 | 27
Gowers sign 1 | 24
Gowers sign present 1 | 24
Head and Neck Neoplasms 1 | 26
Hereditary Breast and Ovarian Cancer Syndrome 1 | 14
Hypoplastic mandible condyle 1 | 275
Impaired exercise tolerance 1 | 42
Increased chromosomal breakage 1 | 27
Irregular hyperpigmentation 1 | 33
Isolated Growth Hormone Deficiency, Type 1A 1 | 6
Kyphoscoliosis deformity of spine 1 | 60
Leukopenia 1 | 72
Limb-girdle muscle weakness 1 | 12
Malignant neoplasm of breast 1 | 15
Mammary Neoplasms 1 | 425
Mandibular hypoplasia 1 | 275
Micrognathism 1 | 275
Micronuclei, Chromosome-Defective 1 | 25
Mirror movements 2 1 | 1
Mirror movements disorder 1 | 8
Mitochondrial DNA deletion syndrome with progressive myopathy 1 | 1
Muscle Cramp 1 | 55
Myalgia 1 | 54
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL DOMINANT 6 1 | 1
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL DOMINANT, 6 1 | 1
Pyridoxine-responsive sideroblastic anemia 1 | 17
Radial aplasia/hypoplasia 1 | 29
Retinitis pigmentosa 4 1 | 38
Seckel syndrome 1 | 34
Seckel syndrome 8 1 | 1
Short palpebral fissure 1 | 38
Slender build 1 | 14
Slow progression 1 | 89
Thrombocytopenia 1 | 197
Xeroderma pigmentosum 1 | 43
adrenocortical carcinoma 1 | 1,428
breast carcinoma 1 | 1,638
cystic fibrosis 1 | 1,696
hypopigmented skin patch 1 | 59
invasive ductal carcinoma 1 | 2,951
nasopharyngeal carcinoma 1 | 1,058
non-small cell lung carcinoma 1 | 317

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Enzyme 3 | 4,145
Non-IDG 1 | 12,091

GO Function

single-stranded DNA-dependent ... 4 | 4
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase theta POLQ Tbio Enzyme -1.61640 40.0 57
E3 ubiquitin-protein ligase RAD18 RAD18 Tbio Enzyme -2.22905 169.1 271
DNA replication ATP-dependent helicase/nuclease DNA2 DNA2 Tbio Enzyme -2.42159 256.1 101
DNA repair protein RAD51 homolog 1 RAD51 Tchem Non-IDG -3.82649 6590.0 594