Development Level

Tbio 4 | 11,445

IMPC Phenotype

abnormal vertebrae morphology 1 | 18
decreased body weight 1 | 161
decreased circulating glycerol... 1 | 16
increased circulating triglyce... 1 | 42
increased startle reflex 1 | 112
tremors 1 | 39

Disease

Carcinoma 3 | 11,493
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
lung cancer 3 | 4,740
medulloblastoma, large-cell 3 | 6,241
osteosarcoma 3 | 7,950
ovarian cancer 3 | 8,520
Autosomal recessive predisposition 2 | 1,442
Cancer 2 | 2,499
adult high grade glioma 2 | 3,801
colon cancer 2 | 1,478
inflammatory breast cancer 2 | 286
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
oligodendroglioma 2 | 2,850
Abnormal visual pursuit 1 | 14
Absent earlobe 1 | 9
Agenesis of teeth 1 | 21
Aggressive behavior 1 | 75
Aggressive reaction 1 | 75
Ataxia telangiectasia 1 | 34
Atrophy of cerebellum 1 | 103
Bunion 1 | 26
Cachexia 1 | 50
Cerebellar degeneration 1 | 103
Chorea 1 | 29
Choreatic disease 1 | 52
Cone-shaped epiphyses 1 | 24
Congenital microcephaly 1 | 2
Convex nasal ridge 1 | 37
DNA ligase IV deficiency 1 | 7
Decreased size of teeth 1 | 62
Decreased tendon reflex 1 | 122
Decreased width of tooth 1 | 59
Defective tooth enamel 1 | 31
Distal amyotrophy 1 | 51
Downward slant of palpebral fissure 1 | 158
Dysarthria 1 | 192
Dysdiadochokinesis 1 | 25
Dystonia 1 | 164
Dystonic disease 1 | 106
Dystrophic tooth enamel 1 | 31
Enamel abnormalities 1 | 31
Frequent falls 1 | 12
Gait Ataxia 1 | 51
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hallux Valgus 1 | 26
Head circumference small for gestational age 1 | 2
Heart murmur 1 | 5
Hereditary Breast and Ovarian Cancer Syndrome 1 | 14
Highly variable severity 1 | 157
Hip Dislocation, Congenital 1 | 48
Hyperplasia of nose 1 | 23
Hypertrophy of nose 1 | 23
Impaired cognition 1 | 96
Impaired smooth pursuit 1 | 14
Infratentorial atrophy 1 | 103
Intracranial aneurysm 1 | 24
Joint hyperflexibility 1 | 78
Large nose 1 | 23
Low Birth Weights 1 | 69
Lower limb spasticity 1 | 10
Mental impairment 1 | 95
Microcephaly 1 | 166
Microdontia (disorder) 1 | 59
Microglossia 1 | 10
Mild global developmental delay 1 | 14
Multiple Sclerosis 1 | 540
Narrow face 1 | 54
Narrow forehead 1 | 34
Nijmegen breakage syndrome 1 | 24
Nystagmus, End-Position 1 | 12
Omenn syndrome 1 | 13
Penile hypospadias 1 | 106
Physical aggression 1 | 76
Poor growth 1 | 114
Precociously senile appearance 1 | 18
Progressive disorder 1 | 142
Psychomotor retardation, mild 1 | 14
Reduced number of teeth 1 | 21
Reticuloendotheliosis, familial, with eosinophilia 1 | 3
Retrognathia 1 | 54
Sandal gap 1 | 24
Seckel syndrome 1 | 34
Severe combined immunodeficiency 1 | 51
Short middle phalanx of the 5th finger 1 | 13
Skull malformation 1 | 38
Small for gestational age (disorder) 1 | 69
Small tongue 1 | 10
Sparse scalp hair 1 | 42
Spider Veins 1 | 17
Telangiectasis 1 | 36
Thin face 1 | 54
Thoracic scoliosis 1 | 4
Variable expressivity 1 | 157
Very poor growth 1 | 114
microcephaly-digital anomalies syndrome 1 | 1
posterior fossa group B ependymoma 1 | 416

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Non-IDG 2 | 12,091
Enzyme 1 | 4,145
Epigenetic 1 | 242

GO Function

single-stranded DNA endodeoxyr... 4 | 4
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Protein artemis DCLRE1C Tbio Non-IDG -2.27419 184.9 252
Double-strand break repair protein MRE11 MRE11 Tbio Non-IDG -2.02762 98.5 459
Histone-lysine N-methyltransferase SETMAR SETMAR Tbio Epigenetic -1.33346 26.5 119