Development Level

Tbio 75 | 11,651
Tdark 9 | 6,593
Tchem 7 | 1,388
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
embryonic lethality prior to o... 3 | 239
enlarged heart 3 | 210
abnormal heart morphology 2 | 162
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
increased startle reflex 2 | 112
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal limb morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal vertebrae morphology 1 | 18
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
female infertility 1 | 60
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
male infertility 1 | 123
small heart 1 | 10
tremors 1 | 39

Disease

ovarian cancer 59 | 8,520
Carcinoma 54 | 11,493
osteosarcoma 47 | 7,950
medulloblastoma, large-cell 42 | 6,241
lung cancer 39 | 4,740
psoriasis 38 | 6,694
group 3 medulloblastoma 35 | 4,104
glioblastoma 34 | 5,792
Breast cancer 33 | 3,578
atypical teratoid / rhabdoid tumor 28 | 5,112
Cancer 27 | 2,499
malignant mesothelioma 26 | 3,232
adult high grade glioma 22 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
primitive neuroectodermal tumor 21 | 3,035
Multiple myeloma 19 | 1,332
ependymoma 19 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
lung adenocarcinoma 18 | 2,716
Waldenstrons macroglobulinemia 17 | 765
non-small cell lung cancer 17 | 2,890
Autosomal recessive predisposition 15 | 1,442
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
invasive ductal carcinoma 14 | 2,951
oligodendroglioma 13 | 2,850
Intellectual disability 12 | 1,016
Kidney cancer 12 | 2,613
Xeroderma pigmentosum 12 | 43
acute quadriplegic myopathy 12 | 1,158
colon cancer 12 | 1,478
pancreatic cancer 12 | 2,398
Pick disease 11 | 1,894
nasopharyngeal carcinoma 11 | 1,058
tuberculosis 11 | 2,010
Fanconi anemia 10 | 56
Muscle hypotonia 10 | 571
Small head 10 | 374
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Short stature 9 | 531
adrenocortical carcinoma 9 | 1,428
astrocytic glioma 9 | 2,597
breast carcinoma 9 | 1,638
dermatomyositis 9 | 966
ductal carcinoma in situ 9 | 1,745
juvenile dermatomyositis 9 | 1,187
subependymal giant cell astrocytoma 9 | 2,287
Astrocytoma, Pilocytic 8 | 3,081
Breast Neoplasms 8 | 445
Cockayne syndrome 8 | 60
Epilepsy 8 | 792
Mammary Neoplasms 8 | 425
astrocytoma 8 | 1,146
lung carcinoma 8 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Acquired scoliosis 7 | 281
Cataract 7 | 297
Chromosome Breakage 7 | 36
Curvature of spine 7 | 282
Lens Opacities 7 | 231
Neurodegenerative disease 7 | 414
Seizures 7 | 596
Strabismus 7 | 270
Thrombocytopenia 7 | 197
diabetes mellitus 7 | 1,728
hypopigmented skin patch 7 | 59
pituitary cancer 7 | 1,972
primary Sjogren syndrome 7 | 735
Cryptorchidism 6 | 296
Decreased platelet count 6 | 111
Failure to gain weight 6 | 365
Fatigue 6 | 182
Fetal Growth Retardation 6 | 189
Fever 6 | 138
Increased chromosomal breakage 6 | 27
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Lynch syndrome 6 | 35
Pediatric failure to thrive 6 | 365
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
Adenocarcinoma of lung 5 | 142
Amyotrophic lateral sclerosis 5 | 451
Endometriosis 5 | 540
Hypogonadism 5 | 173
Melanoma 5 | 711
Sensorineural Hearing Loss (disorder) 5 | 284
Short palpebral fissure 5 | 38
atypical teratoid/rhabdoid tumor 5 | 357
cystic fibrosis 5 | 1,696
hepatocellular carcinoma 5 | 547
hereditary spastic paraplegia 5 | 318
pancreatic carcinoma 5 | 562
pediatric high grade glioma 5 | 1,064
progressive supranuclear palsy 5 | 676
tuberculosis and treatment for 6 months 5 | 409

Tissue

Blood and immune system 86 | 16,909
Digestive Tract 86 | 17,369
Endocrine System 86 | 18,159
Female tissues 86 | 17,400
Nervous System 86 | 16,725
Skin and soft tissues 86 | 17,230
Liver and Pancreas 85 | 16,750
Male tissues 85 | 17,142
Urinary Tract 85 | 16,678
Cardiovascular System 84 | 15,192
Respiratory system 84 | 16,393

Target Family

Non-IDG 57 | 12,091
Enzyme 25 | 4,145
Transcription Factor 8 | 1,400
Epigenetic 1 | 242
Kinase 1 | 634

GO Function

single-stranded DNA binding 92 | 92
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase III subunit RPC3 POLR3C Tbio Enzyme -0.84213 6.37 136
CST complex subunit TEN1 TEN1 Tbio Non-IDG -2.18182 142.0 8
Single-stranded DNA-binding protein 3 SSBP3 Tbio Non-IDG -1.53585 34.1 98
Single-stranded DNA-binding protein 4 SSBP4 Tdark Non-IDG -0.17609 1.13 55
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.77350 60.4 174
DNA repair protein complementing XP-C cells XPC Tbio Non-IDG -2.21142 154.0 208
Twinkle protein, mitochondrial TWNK Tbio Non-IDG -2.18726 156.1 146
DNA repair protein RAD51 homolog 3 RAD51C Tbio Non-IDG -1.92798 88.3 269
DNA repair protein XRCC2 XRCC2 Tbio Non-IDG -2.76304 492.9 270
DNA mismatch repair protein Mlh3 MLH3 Tbio Non-IDG -1.78372 64.5 112