Development Level

Tbio 147 | 11,445
Tchem 41 | 1,598
Tdark 13 | 6,588
Tclin 7 | 613

Collection

Kinase: IDG Consortium (Target... 4 | 125
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 8 | 499
abnormal bone structure 7 | 187
decreased body weight 6 | 161
abnormal behavior 5 | 298
abnormal embryo size 5 | 220
abnormal gait 5 | 69
decreased fasted circulating g... 5 | 65
increased startle reflex 5 | 112
decreased circulating triglyce... 4 | 79
increased circulating calcium ... 4 | 34
increased lean body mass 4 | 172
decreased circulating alkaline... 3 | 46
decreased circulating iron lev... 3 | 32
decreased grip strength 3 | 116
decreased mean corpuscular vol... 3 | 79
impaired righting response 3 | 26
increased circulating triglyce... 3 | 42
increased lymphocyte cell numb... 3 | 32
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
tremors 3 | 39
abnormal bone mineralization 2 | 38
abnormal clavicle morphology 2 | 6
abnormal digit morphology 2 | 10
abnormal joint morphology 2 | 23
abnormal locomotor behavior 2 | 24
abnormal rib morphology 2 | 10
abnormal spleen morphology 2 | 55
abnormal vocalization 2 | 21
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased circulating amylase ... 2 | 28
decreased circulating free fat... 2 | 31
decreased circulating glucose ... 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating creatini... 2 | 38
increased circulating total pr... 2 | 28
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased or absent threshold ... 2 | 101
limb grasping 2 | 41
short tibia 2 | 97
small superior vagus ganglion 2 | 74
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal eyelid morphology 1 | 7
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 12
abnormal retinal vasculature m... 1 | 27
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
absent teeth 1 | 3
cataract 1 | 92
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased red blood cell distr... 1 | 34
long tibia 1 | 25
prenatal lethality 1 | 28
small kidney 1 | 16
small thymus 1 | 16
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

Carcinoma 133 | 11,493
osteosarcoma 116 | 7,950
ovarian cancer 108 | 8,520
glioblastoma 95 | 5,792
medulloblastoma, large-cell 94 | 6,241
psoriasis 89 | 6,694
lung cancer 79 | 4,740
ependymoma 72 | 4,679
atypical teratoid / rhabdoid tumor 71 | 5,112
Cancer 60 | 2,499
Breast cancer 59 | 3,578
adult high grade glioma 57 | 3,801
lung carcinoma 57 | 2,843
Astrocytoma, Pilocytic 53 | 3,081
malignant mesothelioma 49 | 3,232
subependymal giant cell astrocytoma 49 | 2,287
primitive neuroectodermal tumor 47 | 3,035
astrocytic glioma 46 | 2,597
ulcerative colitis 46 | 1,819
non-small cell lung cancer 45 | 2,890
group 3 medulloblastoma 44 | 4,104
oligodendroglioma 44 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,291
invasive ductal carcinoma 43 | 2,951
group 4 medulloblastoma 42 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
pituitary cancer 39 | 1,972
interstitial cystitis 38 | 2,312
pancreatic cancer 38 | 2,398
tuberculosis 36 | 2,010
Pick disease 35 | 1,894
lung adenocarcinoma 34 | 2,716
Kidney cancer 33 | 2,613
breast carcinoma 27 | 1,638
cystic fibrosis 26 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
diabetes mellitus 25 | 1,728
ductal carcinoma in situ 25 | 1,745
juvenile dermatomyositis 25 | 1,187
cutaneous lupus erythematosus 24 | 1,057
Rheumatoid arthritis 23 | 1,191
Liver Cirrhosis, Experimental 22 | 769
colon cancer 21 | 1,478
Multiple myeloma 20 | 1,332
pediatric high grade glioma 20 | 1,064
Autosomal recessive predisposition 19 | 1,442
Schizophrenia 19 | 1,160
active Crohn's disease 19 | 922
acute quadriplegic myopathy 19 | 1,158
astrocytoma 18 | 1,146
dermatomyositis 18 | 966
esophageal adenocarcinoma 18 | 737
primary pancreatic ductal adenocarcinoma 17 | 1,109
gastric carcinoma 16 | 807
spina bifida 16 | 1,074
Melanoma 15 | 711
active ulcerative colitis 15 | 764
adrenocortical carcinoma 15 | 1,428
nasopharyngeal carcinoma 15 | 1,058
Alzheimer's disease 14 | 658
Intellectual disability 14 | 1,016
Multiple Sclerosis 14 | 540
Atopic dermatitis 13 | 952
Prostatic Neoplasms 13 | 495
primary Sjogren syndrome 13 | 735
Bipolar Disorder 12 | 666
Breast Neoplasms 12 | 445
Crohn's disease 12 | 321
Obesity 12 | 678
Skin cancer 12 | 469
Asthma 11 | 385
Duchenne muscular dystrophy 11 | 601
Mammary Neoplasms 11 | 425
Osteoporosis 11 | 363
Waldenstrons macroglobulinemia 11 | 765
Epilepsy 10 | 792
Kidney disease 10 | 430
Short stature 10 | 531
hepatocellular carcinoma 10 | 547
mucosa-associated lymphoid tissue lymphoma 10 | 484
non primary Sjogren syndrome sicca 10 | 891
Carcinoma, Hepatocellular 9 | 228
Dull intelligence 9 | 645
Endometriosis 9 | 540
Hypertension 9 | 396
Liver carcinoma 9 | 240
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Seizures 9 | 596
medulloblastoma 9 | 720
progressive supranuclear palsy 9 | 676
Cognitive delay 8 | 608
Gait abnormality 8 | 135
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
acute myeloid leukemia 8 | 783
sonic hedgehog group medulloblastoma 8 | 467

Tissue

Endocrine System 201 | 18,159
Digestive Tract 198 | 17,369
Skin and soft tissues 197 | 17,230
Blood and immune system 195 | 16,909
Female tissues 195 | 17,400
Male tissues 194 | 17,142
Liver and Pancreas 193 | 16,750
Nervous System 193 | 16,725
Urinary Tract 193 | 16,678
Respiratory system 190 | 16,393
Cardiovascular System 189 | 15,192

Target Family

Non-IDG 130 | 12,091
Enzyme 34 | 4,145
Kinase 25 | 634
Transcription Factor 9 | 1,400
Transporter 4 | 473
Epigenetic 2 | 242
GPCR 2 | 408
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

GO Function

signal transducer activity 208 | 208
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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