Development Level

Tbio 2 | 11,445

Disease

osteosarcoma 2 | 7,950
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 1 | 21
ATRIAL SEPTAL DEFECT 7 WITH OR WITHOUT ATRIOVENTRICULAR CONDUCTION DEFECTS 1 | 1
Abdomen distended 1 | 43
Abnormal nasal morphology 1 | 16
Abnormality of metabolism/homeostasis 1 | 134
Asplenia, isolated congenital 1 | 2
Athyreosis 1 | 4
Athyroidal hypothyroidism 1 | 5
Atrial heart septal defect 1 | 18
Atrioventricular Septal Defect 1 | 22
Atrioventricular block 1 | 35
Brachydactyly 1 | 156
Broad forehead 1 | 59
Broad hallux 1 | 29
Cardiac Arrhythmia 1 | 103
Cardiac conduction abnormalities 1 | 78
Cardiomegaly 1 | 116
Cardiomyopathy 1 | 116
Cardiomyopathy, Dilated 1 | 83
Chromosome 5, monosomy 5q35 1 | 2
Coarse facial features 1 | 108
Conduction disorder of the heart 1 | 79
Congenital atresia of aortic valve 1 | 1
Congenital atresia of mitral valve 1 | 2
Congenital heart disease 1 | 93
Congenital hypoplasia of aortic arch 1 | 2
Congenital hypothyroidism 1 | 26
Conotruncal Heart Malformations 1 | 10
Constipation 1 | 181
Discordant ventriculoarterial connection 1 | 17
Double Outlet Right Ventricle 1 | 11
Dyschezia 1 | 135
EKG abnormalities 1 | 78
Ebstein anomaly 1 | 16
Ectopic thyroid tissue (disorder) 1 | 2
Electrocardiogram abnormal 1 | 81
Electrocardiogram change 1 | 78
Exophthalmos 1 | 112
Familial atrial fibrillation 1 | 23
Familial progressive cardiac conduction defect 1 | 4
Fatigue 1 | 182
Fetal alcohol syndrome 1 | 22
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
HIV Infections 1 | 102
HYPOTHYROIDISM, CONGENITAL, DUE TO THYROID DYSGENESIS 1 | 4
HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 5 (disorder) 1 | 1
Heart Septal Defects, Ventricular 1 | 6
Hereditary bundle branch system defect 1 | 4
Holt-Oram syndrome 1 | 12
Hypersomnia 1 | 8
Hypertrophic pyloric stenosis 1 | 3
Hypoplastic Left Heart Syndrome 1 | 14
Hypoplastic Left Heart Syndrome 2 1 | 1
Hypothyroidism 1 | 122
Hypothyroidism, congenital, nongoitrous, 5 1 | 1
Icterus 1 | 82
Large bregma sutures 1 | 46
Large fontanelle 1 | 46
Large, late-closing fontanelle 1 | 46
Long narrow head 1 | 75
Macroglossia 1 | 65
Muscle Weakness 1 | 170
Myocardial Infarction 1 | 151
Myotonic Dystrophy 1 | 3
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Neoplasms 1 | 63
Neuronal ceroid lipofuscinosis 2 1 | 17
Ostium secundum atrial septal defect 1 | 9
POLYDACTYLY, POSTAXIAL 1 | 13
Persistant truncus arteriosus 1 | 17
Poor growth 1 | 114
Preauricular Fistulae, Congenital 1 | 27
Preauricular dimple 1 | 27
Preauricular sinus 1 | 27
Progressive mental retardation 1 | 37
Prolonged PR interval 1 | 1
Prominent eyes 1 | 96
Prominent globes 1 | 96
Protruding eyes 1 | 96
Right atrial isomerism 1 | 29
Severe mental retardation (I.Q. 20-34) 1 | 99
Splenic Hypoplasia 1 | 2
Tetralogy of Fallot 1 | 63
Thickened facial skin with coarse facial features 1 | 108
Thyroid Agenesis 1 | 5
Thyroid Hypoplasia 1 | 4
Thyroid ectopia 1 | 2
Tricuspid atresia 1 | 7
Turridolichocephaly 1 | 75
Underdeveloped brows 1 | 38
Underdeveloped supraorbital ridges 1 | 38
VENTRICULAR SEPTAL DEFECT 3 1 | 1
Very poor growth 1 | 114
Wide bregma sutures 1 | 46
ventricular septal defect 1 | 20

Tissue

Blood and immune system 2 | 16,909
Cardiovascular System 2 | 15,192
Female tissues 2 | 17,400
Urinary Tract 2 | 16,678
Digestive Tract 1 | 17,369
Endocrine System 1 | 18,159
Liver and Pancreas 1 | 16,750
Male tissues 1 | 17,142
Nervous System 1 | 16,725
Respiratory system 1 | 16,393
Skin and soft tissues 1 | 17,230

Target Family

Transcription Factor 2 | 1,400

GO Function

serum response element binding 2 | 2
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serum response factor SRF Tbio Transcription Factor -2.94583 721.8 474
Homeobox protein Nkx-2.5 NKX2-5 Tbio Transcription Factor -2.79738 600.1 385