Development Level

Tbio 27 | 11,445
Tchem 25 | 1,598
Tdark 8 | 6,588
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo size 2 | 220
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral content 2 | 151
decreased lean body mass 2 | 135
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal eye morphology 1 | 68
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal placenta size 1 | 20
abnormal snout morphology 1 | 23
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased bone mineral density 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased heart rate 1 | 18
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased cardiac muscle contr... 1 | 8
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged ST segment 1 | 36

Disease

Carcinoma 37 | 11,493
psoriasis 31 | 6,694
ovarian cancer 25 | 8,520
osteosarcoma 24 | 7,950
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
medulloblastoma, large-cell 19 | 6,241
Cancer 17 | 2,499
atypical teratoid / rhabdoid tumor 17 | 5,112
glioblastoma 17 | 5,792
Breast cancer 16 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
invasive ductal carcinoma 16 | 2,951
lung adenocarcinoma 16 | 2,716
pancreatic cancer 16 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
lung cancer 15 | 4,740
cystic fibrosis 14 | 1,696
interstitial cystitis 14 | 2,312
diabetes mellitus 13 | 1,728
adult high grade glioma 12 | 3,801
group 3 medulloblastoma 12 | 4,104
lung carcinoma 12 | 2,843
Autosomal recessive predisposition 11 | 1,442
malignant mesothelioma 11 | 3,232
ependymoma 10 | 4,679
ulcerative colitis 10 | 1,819
Atopic dermatitis 9 | 952
Kidney cancer 9 | 2,613
breast carcinoma 8 | 1,638
cutaneous lupus erythematosus 8 | 1,057
primitive neuroectodermal tumor 8 | 3,035
Astrocytoma, Pilocytic 7 | 3,081
Prostatic Neoplasms 7 | 495
esophageal adenocarcinoma 7 | 737
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
primary pancreatic ductal adenocarcinoma 7 | 1,109
Hypertension 6 | 396
colon cancer 6 | 1,478
group 4 medulloblastoma 6 | 1,855
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Kidney disease 5 | 430
Multiple myeloma 5 | 1,332
Obesity 5 | 678
active Crohn's disease 5 | 922
ductal carcinoma in situ 5 | 1,745
gastric carcinoma 5 | 807
Alzheimer's disease 4 | 658
Atherosclerosis 4 | 291
Bipolar Disorder 4 | 666
Cerebrovascular disease 4 | 238
Coronary artery disease 4 | 268
Diabetes mellitus type 2 4 | 69
Duchenne muscular dystrophy 4 | 601
Heart disease 4 | 306
Intellectual disability 4 | 1,016
Liver Cirrhosis, Experimental 4 | 769
Netherton syndrome 4 | 15
Pancreatitis 4 | 123
Schizophrenia 4 | 1,160
acute quadriplegic myopathy 4 | 1,158
astrocytic glioma 4 | 2,597
pediatric high grade glioma 4 | 1,064
primary Sjogren syndrome 4 | 735
Arthritis 3 | 290
Attention deficit hyperactivity disorder 3 | 278
Autism spectrum disorder 3 | 101
Autistic Disorder 3 | 364
Autoimmune Diseases 3 | 67
Dermatitis 3 | 157
Dull intelligence 3 | 645
Endometriosis 3 | 540
Epilepsy 3 | 792
Hypersensitivity reaction type II disease 3 | 253
Influenza 3 | 142
Lipid metabolism disorder 3 | 114
Lung disease 3 | 142
Major Depressive Disorder 3 | 301
Melanoma 3 | 711
Mental deficiency 3 | 645
Multiple Sclerosis 3 | 540
Neurodegenerative disease 3 | 414
Pick disease 3 | 1,894
Poor school performance 3 | 645
Prostate cancer 3 | 175
Vasculitis 3 | 80
Waldenstrons macroglobulinemia 3 | 765
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
fibroadenoma 3 | 559
limb girdle muscular dystrophy 2A 3 | 213
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
nephrosclerosis 3 | 333
pancreatic carcinoma 3 | 562
spina bifida 3 | 1,074
urothelial carcinoma 3 | 318

Tissue

Female tissues 64 | 17,400
Digestive Tract 63 | 17,369
Skin and soft tissues 63 | 17,230
Endocrine System 62 | 18,159
Liver and Pancreas 58 | 16,750
Male tissues 58 | 17,142
Urinary Tract 58 | 16,678
Nervous System 57 | 16,725
Blood and immune system 56 | 16,909
Respiratory system 55 | 16,393
Cardiovascular System 45 | 15,192

Target Family

Enzyme 60 | 4,145
Non-IDG 5 | 12,091

GO Function

serine-type peptidase activity 65 | 65
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Transmembrane protease serine 11E TMPRSS11E Tbio Enzyme -0.90309 9.71 126
N-acetylated-alpha-linked acidic dipeptidase 2 NAALAD2 Tchem Enzyme -1.51589 30.6 39
Serine protease 27 PRSS27 Tbio Enzyme -2.20602 159.4 151
Reelin RELN Tbio Non-IDG -2.78255 645.2 121
Dipeptidyl peptidase 2 DPP7 Tchem Enzyme -2.23445 172.1 187
Prolyl endopeptidase FAP FAP Tchem Enzyme -2.37686 226.2 406
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.60032 392.5 519
Prolyl endopeptidase PREP Tchem Enzyme -2.49875 314.7 157